OMICs approaches in diarrhetic shellfish toxins research

Detalhes bibliográficos
Autor(a) principal: Campos, Alexandre
Data de Publicação: 2020
Outros Autores: Freitas, Marisa, Almeida, André M. de, Martins, José Carlos, Dominguez-Pérez, Dany, Osório, Hugo, Vasconcelos, Vitor, Costa, Pedro Reis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/20353
Resumo: Review
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spelling OMICs approaches in diarrhetic shellfish toxins researchdiarrhetic shellfish toxinsaquatic contaminationmechanisms of toxicityrisk assessmenttranscriptomicsproteomicsmetabolomicsReviewDiarrhetic shellfish toxins (DSTs) are among the most prevalent marine toxins in Europe’s and in other temperate coastal regions. These toxins are produced by several dinoflagellate species; however, the contamination of the marine trophic chain is often attributed to species of the genus Dinophysis. This group of toxins, constituted by okadaic acid (OA) and analogous molecules (dinophysistoxins, DTXs), are highly harmful to humans, causing severe poisoning symptoms caused by the ingestion of contaminated seafood. Knowledge on the mode of action and toxicology of OA and the chemical characterization and accumulation of DSTs in seafood species (bivalves, gastropods and crustaceans) has significantly contributed to understand the impacts of these toxins in humans. Considerable information is however missing, particularly at the molecular and metabolic levels involving toxin uptake, distribution, compartmentalization and biotransformation and the interaction of DSTs with aquatic organisms. Recent contributions to the knowledge of DSTs arise from transcriptomics and proteomics research. Indeed, OMICs constitute a research field dedicated to the systematic analysis on the organisms’ metabolisms. The methodologies used in OMICs are also highly e ective to identify critical metabolic pathways a ecting the physiology of the organisms. In this review, we analyze the main contributions provided so far by OMICs to DSTs research and discuss the prospects of OMICs with regard to the DSTs toxicology and the significance of these toxins to public health, food safety and aquacultureMDPIRepositório da Universidade de LisboaCampos, AlexandreFreitas, MarisaAlmeida, André M. deMartins, José CarlosDominguez-Pérez, DanyOsório, HugoVasconcelos, VitorCosta, Pedro Reis2020-09-18T09:52:51Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/20353engToxins 2020, 12, 49310.3390/toxins12080493info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:49:47Zoai:www.repository.utl.pt:10400.5/20353Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:05:07.294252Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv OMICs approaches in diarrhetic shellfish toxins research
title OMICs approaches in diarrhetic shellfish toxins research
spellingShingle OMICs approaches in diarrhetic shellfish toxins research
Campos, Alexandre
diarrhetic shellfish toxins
aquatic contamination
mechanisms of toxicity
risk assessment
transcriptomics
proteomics
metabolomics
title_short OMICs approaches in diarrhetic shellfish toxins research
title_full OMICs approaches in diarrhetic shellfish toxins research
title_fullStr OMICs approaches in diarrhetic shellfish toxins research
title_full_unstemmed OMICs approaches in diarrhetic shellfish toxins research
title_sort OMICs approaches in diarrhetic shellfish toxins research
author Campos, Alexandre
author_facet Campos, Alexandre
Freitas, Marisa
Almeida, André M. de
Martins, José Carlos
Dominguez-Pérez, Dany
Osório, Hugo
Vasconcelos, Vitor
Costa, Pedro Reis
author_role author
author2 Freitas, Marisa
Almeida, André M. de
Martins, José Carlos
Dominguez-Pérez, Dany
Osório, Hugo
Vasconcelos, Vitor
Costa, Pedro Reis
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Campos, Alexandre
Freitas, Marisa
Almeida, André M. de
Martins, José Carlos
Dominguez-Pérez, Dany
Osório, Hugo
Vasconcelos, Vitor
Costa, Pedro Reis
dc.subject.por.fl_str_mv diarrhetic shellfish toxins
aquatic contamination
mechanisms of toxicity
risk assessment
transcriptomics
proteomics
metabolomics
topic diarrhetic shellfish toxins
aquatic contamination
mechanisms of toxicity
risk assessment
transcriptomics
proteomics
metabolomics
description Review
publishDate 2020
dc.date.none.fl_str_mv 2020-09-18T09:52:51Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/20353
url http://hdl.handle.net/10400.5/20353
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Toxins 2020, 12, 493
10.3390/toxins12080493
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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