Management of asthma in childhood

Detalhes bibliográficos
Autor(a) principal: Mathioudakis, Alexander G.
Data de Publicação: 2021
Outros Autores: Miligkos, Michael, Boccabella, Cristina, Alimani, Gioulinta S., Custovic, Adnan, Deschildre, A., Ducharme, Francine Monique, Kalayci, Omer, Murray, Clare, Garcia, Antonio Nieto, Phipatanakul, Wanda, Price, David, Sheikh, Aziz, Agache, Ioana Octavia, Bacharier, Leonard, Beloukas, Apostolos, Bentley, Andrew, Bonini, Matteo, Castro-Rodriguez, Jose A., De Carlo, Giuseppe, Craig, Timothy, Diamant, Zuzana, Feleszko, Wojciech, Felton, Tim, Gern, James E., Grigg, Jonathan, Hedlin, Gunilla, Hossny, Elham M., Ierodiakonou, Despo, Jartti, Tuomas, Kaplan, Alan, Lemanske, Robert F., Le Souëf, Peter N., Mäkelä, Mika J., Mathioudakis, Georgios A., Matricardi, Paolo, Mitrogiorgou, Marina, Morais-Almeida, Mario, Nagaraju, Karthik, Papageorgiou, Effie, Pité, Helena, Pitrez, Paulo M.C., Pohunek, Petr, Roberts, Graham, Tsiligianni, Ioanna, Turner, Stephen, Vijverberg, Susanne, Winders, Tonya A., Wong, Gary W.K., Xepapadaki, Paraskevi, Zar, Heather J., Papadopoulos, Nikolaos G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/121556
Resumo: Funding Information: AGM was supported by the National Institute of Health Research Manchester Biomedical Research Centre (NIHR Manchester BRC). We thank Mrs Maria Kritikou for excellent administrative support of the study Publisher Copyright: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
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spelling Management of asthma in childhoodStudy protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tankasthmapaediatric thoracic medicinepaediatricsthoracic medicineMedicine(all)Funding Information: AGM was supported by the National Institute of Health Research Manchester Biomedical Research Centre (NIHR Manchester BRC). We thank Mrs Maria Kritikou for excellent administrative support of the study Publisher Copyright: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.Introduction Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The Paediatric Asthma in Real Life (PeARL) Think Tank aspires to develop recommendations based on the best available evidence from studies in children. An overview of systematic reviews (SRs) on paediatric asthma maintenance management and an SR of treatments for acute asthma attacks in children, requiring an emergency presentation with/without hospital admission will be conducted. Methods and analysis Standard methodology recommended by Cochrane will be followed. Maintenance pharmacotherapy of childhood asthma will be evaluated in an overview of SRs published after 2005 and including clinical trials or real-life studies. For evaluating pharmacotherapy of acute asthma attacks leading to an emergency presentation with/without hospital admission, we opted to conduct de novo synthesis in the absence of adequate up-to-date published SRs. For the SR of acute asthma pharmacotherapy, we will consider eligible SRs, clinical trials or real-life studies without time restrictions. Our evidence updates will be based on broad searches of Pubmed/Medline and the Cochrane Library. We will use A MeaSurement Tool to Assess systematic Reviews, V.2, Cochrane risk of bias 2 and REal Life EVidence AssessmeNt Tool to evaluate the methodological quality of SRs, controlled clinical trials and real-life studies, respectively. Next, we will further assess interventions for acute severe asthma attacks with positive clinical results in meta-analyses. We will include both controlled clinical trials and observational studies and will assess their quality using the previously mentioned tools. We will employ random effect models for conducting meta-analyses, and Grading of Recommendations Assessment, Development and Evaluation methodology to assess certainty in the body of evidence. Ethics and dissemination Ethics approval is not required for SRs. Our findings will be published in peer reviewed journals and will inform clinical recommendations being developed by the PeARL Think Tank. PROSPERO registration numbers CRD42020132990, CRD42020171624.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMathioudakis, Alexander G.Miligkos, MichaelBoccabella, CristinaAlimani, Gioulinta S.Custovic, AdnanDeschildre, A.Ducharme, Francine MoniqueKalayci, OmerMurray, ClareGarcia, Antonio NietoPhipatanakul, WandaPrice, DavidSheikh, AzizAgache, Ioana OctaviaBacharier, LeonardBeloukas, ApostolosBentley, AndrewBonini, MatteoCastro-Rodriguez, Jose A.De Carlo, GiuseppeCraig, TimothyDiamant, ZuzanaFeleszko, WojciechFelton, TimGern, James E.Grigg, JonathanHedlin, GunillaHossny, Elham M.Ierodiakonou, DespoJartti, TuomasKaplan, AlanLemanske, Robert F.Le Souëf, Peter N.Mäkelä, Mika J.Mathioudakis, Georgios A.Matricardi, PaoloMitrogiorgou, MarinaMorais-Almeida, MarioNagaraju, KarthikPapageorgiou, EffiePité, HelenaPitrez, Paulo M.C.Pohunek, PetrRoberts, GrahamTsiligianni, IoannaTurner, StephenVijverberg, SusanneWinders, Tonya A.Wong, Gary W.K.Xepapadaki, ParaskeviZar, Heather J.Papadopoulos, Nikolaos G.2021-07-23T22:20:33Z2021-07-022021-07-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/121556eng2044-6055PURE: 32497760https://doi.org/10.1136/bmjopen-2020-048338info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:03:49Zoai:run.unl.pt:10362/121556Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:44:41.047315Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Management of asthma in childhood
Study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank
title Management of asthma in childhood
spellingShingle Management of asthma in childhood
Mathioudakis, Alexander G.
asthma
paediatric thoracic medicine
paediatrics
thoracic medicine
Medicine(all)
title_short Management of asthma in childhood
title_full Management of asthma in childhood
title_fullStr Management of asthma in childhood
title_full_unstemmed Management of asthma in childhood
title_sort Management of asthma in childhood
author Mathioudakis, Alexander G.
author_facet Mathioudakis, Alexander G.
Miligkos, Michael
Boccabella, Cristina
Alimani, Gioulinta S.
Custovic, Adnan
Deschildre, A.
Ducharme, Francine Monique
Kalayci, Omer
Murray, Clare
Garcia, Antonio Nieto
Phipatanakul, Wanda
Price, David
Sheikh, Aziz
Agache, Ioana Octavia
Bacharier, Leonard
Beloukas, Apostolos
Bentley, Andrew
Bonini, Matteo
Castro-Rodriguez, Jose A.
De Carlo, Giuseppe
Craig, Timothy
Diamant, Zuzana
Feleszko, Wojciech
Felton, Tim
Gern, James E.
Grigg, Jonathan
Hedlin, Gunilla
Hossny, Elham M.
Ierodiakonou, Despo
Jartti, Tuomas
Kaplan, Alan
Lemanske, Robert F.
Le Souëf, Peter N.
Mäkelä, Mika J.
Mathioudakis, Georgios A.
Matricardi, Paolo
Mitrogiorgou, Marina
Morais-Almeida, Mario
Nagaraju, Karthik
Papageorgiou, Effie
Pité, Helena
Pitrez, Paulo M.C.
Pohunek, Petr
Roberts, Graham
Tsiligianni, Ioanna
Turner, Stephen
Vijverberg, Susanne
Winders, Tonya A.
Wong, Gary W.K.
Xepapadaki, Paraskevi
Zar, Heather J.
Papadopoulos, Nikolaos G.
author_role author
author2 Miligkos, Michael
Boccabella, Cristina
Alimani, Gioulinta S.
Custovic, Adnan
Deschildre, A.
Ducharme, Francine Monique
Kalayci, Omer
Murray, Clare
Garcia, Antonio Nieto
Phipatanakul, Wanda
Price, David
Sheikh, Aziz
Agache, Ioana Octavia
Bacharier, Leonard
Beloukas, Apostolos
Bentley, Andrew
Bonini, Matteo
Castro-Rodriguez, Jose A.
De Carlo, Giuseppe
Craig, Timothy
Diamant, Zuzana
Feleszko, Wojciech
Felton, Tim
Gern, James E.
Grigg, Jonathan
Hedlin, Gunilla
Hossny, Elham M.
Ierodiakonou, Despo
Jartti, Tuomas
Kaplan, Alan
Lemanske, Robert F.
Le Souëf, Peter N.
Mäkelä, Mika J.
Mathioudakis, Georgios A.
Matricardi, Paolo
Mitrogiorgou, Marina
Morais-Almeida, Mario
Nagaraju, Karthik
Papageorgiou, Effie
Pité, Helena
Pitrez, Paulo M.C.
Pohunek, Petr
Roberts, Graham
Tsiligianni, Ioanna
Turner, Stephen
Vijverberg, Susanne
Winders, Tonya A.
Wong, Gary W.K.
Xepapadaki, Paraskevi
Zar, Heather J.
Papadopoulos, Nikolaos G.
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dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Mathioudakis, Alexander G.
Miligkos, Michael
Boccabella, Cristina
Alimani, Gioulinta S.
Custovic, Adnan
Deschildre, A.
Ducharme, Francine Monique
Kalayci, Omer
Murray, Clare
Garcia, Antonio Nieto
Phipatanakul, Wanda
Price, David
Sheikh, Aziz
Agache, Ioana Octavia
Bacharier, Leonard
Beloukas, Apostolos
Bentley, Andrew
Bonini, Matteo
Castro-Rodriguez, Jose A.
De Carlo, Giuseppe
Craig, Timothy
Diamant, Zuzana
Feleszko, Wojciech
Felton, Tim
Gern, James E.
Grigg, Jonathan
Hedlin, Gunilla
Hossny, Elham M.
Ierodiakonou, Despo
Jartti, Tuomas
Kaplan, Alan
Lemanske, Robert F.
Le Souëf, Peter N.
Mäkelä, Mika J.
Mathioudakis, Georgios A.
Matricardi, Paolo
Mitrogiorgou, Marina
Morais-Almeida, Mario
Nagaraju, Karthik
Papageorgiou, Effie
Pité, Helena
Pitrez, Paulo M.C.
Pohunek, Petr
Roberts, Graham
Tsiligianni, Ioanna
Turner, Stephen
Vijverberg, Susanne
Winders, Tonya A.
Wong, Gary W.K.
Xepapadaki, Paraskevi
Zar, Heather J.
Papadopoulos, Nikolaos G.
dc.subject.por.fl_str_mv asthma
paediatric thoracic medicine
paediatrics
thoracic medicine
Medicine(all)
topic asthma
paediatric thoracic medicine
paediatrics
thoracic medicine
Medicine(all)
description Funding Information: AGM was supported by the National Institute of Health Research Manchester Biomedical Research Centre (NIHR Manchester BRC). We thank Mrs Maria Kritikou for excellent administrative support of the study Publisher Copyright: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-23T22:20:33Z
2021-07-02
2021-07-02T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/121556
url http://hdl.handle.net/10362/121556
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2044-6055
PURE: 32497760
https://doi.org/10.1136/bmjopen-2020-048338
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eu_rights_str_mv openAccess
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