Management of asthma in childhood
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/121556 |
Resumo: | Funding Information: AGM was supported by the National Institute of Health Research Manchester Biomedical Research Centre (NIHR Manchester BRC). We thank Mrs Maria Kritikou for excellent administrative support of the study Publisher Copyright: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Copyright: Copyright 2021 Elsevier B.V., All rights reserved. |
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Management of asthma in childhoodStudy protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tankasthmapaediatric thoracic medicinepaediatricsthoracic medicineMedicine(all)Funding Information: AGM was supported by the National Institute of Health Research Manchester Biomedical Research Centre (NIHR Manchester BRC). We thank Mrs Maria Kritikou for excellent administrative support of the study Publisher Copyright: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.Introduction Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The Paediatric Asthma in Real Life (PeARL) Think Tank aspires to develop recommendations based on the best available evidence from studies in children. An overview of systematic reviews (SRs) on paediatric asthma maintenance management and an SR of treatments for acute asthma attacks in children, requiring an emergency presentation with/without hospital admission will be conducted. Methods and analysis Standard methodology recommended by Cochrane will be followed. Maintenance pharmacotherapy of childhood asthma will be evaluated in an overview of SRs published after 2005 and including clinical trials or real-life studies. For evaluating pharmacotherapy of acute asthma attacks leading to an emergency presentation with/without hospital admission, we opted to conduct de novo synthesis in the absence of adequate up-to-date published SRs. For the SR of acute asthma pharmacotherapy, we will consider eligible SRs, clinical trials or real-life studies without time restrictions. Our evidence updates will be based on broad searches of Pubmed/Medline and the Cochrane Library. We will use A MeaSurement Tool to Assess systematic Reviews, V.2, Cochrane risk of bias 2 and REal Life EVidence AssessmeNt Tool to evaluate the methodological quality of SRs, controlled clinical trials and real-life studies, respectively. Next, we will further assess interventions for acute severe asthma attacks with positive clinical results in meta-analyses. We will include both controlled clinical trials and observational studies and will assess their quality using the previously mentioned tools. We will employ random effect models for conducting meta-analyses, and Grading of Recommendations Assessment, Development and Evaluation methodology to assess certainty in the body of evidence. Ethics and dissemination Ethics approval is not required for SRs. Our findings will be published in peer reviewed journals and will inform clinical recommendations being developed by the PeARL Think Tank. PROSPERO registration numbers CRD42020132990, CRD42020171624.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMathioudakis, Alexander G.Miligkos, MichaelBoccabella, CristinaAlimani, Gioulinta S.Custovic, AdnanDeschildre, A.Ducharme, Francine MoniqueKalayci, OmerMurray, ClareGarcia, Antonio NietoPhipatanakul, WandaPrice, DavidSheikh, AzizAgache, Ioana OctaviaBacharier, LeonardBeloukas, ApostolosBentley, AndrewBonini, MatteoCastro-Rodriguez, Jose A.De Carlo, GiuseppeCraig, TimothyDiamant, ZuzanaFeleszko, WojciechFelton, TimGern, James E.Grigg, JonathanHedlin, GunillaHossny, Elham M.Ierodiakonou, DespoJartti, TuomasKaplan, AlanLemanske, Robert F.Le Souëf, Peter N.Mäkelä, Mika J.Mathioudakis, Georgios A.Matricardi, PaoloMitrogiorgou, MarinaMorais-Almeida, MarioNagaraju, KarthikPapageorgiou, EffiePité, HelenaPitrez, Paulo M.C.Pohunek, PetrRoberts, GrahamTsiligianni, IoannaTurner, StephenVijverberg, SusanneWinders, Tonya A.Wong, Gary W.K.Xepapadaki, ParaskeviZar, Heather J.Papadopoulos, Nikolaos G.2021-07-23T22:20:33Z2021-07-022021-07-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/121556eng2044-6055PURE: 32497760https://doi.org/10.1136/bmjopen-2020-048338info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:03:49Zoai:run.unl.pt:10362/121556Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:44:41.047315Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Management of asthma in childhood Study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank |
title |
Management of asthma in childhood |
spellingShingle |
Management of asthma in childhood Mathioudakis, Alexander G. asthma paediatric thoracic medicine paediatrics thoracic medicine Medicine(all) |
title_short |
Management of asthma in childhood |
title_full |
Management of asthma in childhood |
title_fullStr |
Management of asthma in childhood |
title_full_unstemmed |
Management of asthma in childhood |
title_sort |
Management of asthma in childhood |
author |
Mathioudakis, Alexander G. |
author_facet |
Mathioudakis, Alexander G. Miligkos, Michael Boccabella, Cristina Alimani, Gioulinta S. Custovic, Adnan Deschildre, A. Ducharme, Francine Monique Kalayci, Omer Murray, Clare Garcia, Antonio Nieto Phipatanakul, Wanda Price, David Sheikh, Aziz Agache, Ioana Octavia Bacharier, Leonard Beloukas, Apostolos Bentley, Andrew Bonini, Matteo Castro-Rodriguez, Jose A. De Carlo, Giuseppe Craig, Timothy Diamant, Zuzana Feleszko, Wojciech Felton, Tim Gern, James E. Grigg, Jonathan Hedlin, Gunilla Hossny, Elham M. Ierodiakonou, Despo Jartti, Tuomas Kaplan, Alan Lemanske, Robert F. Le Souëf, Peter N. Mäkelä, Mika J. Mathioudakis, Georgios A. Matricardi, Paolo Mitrogiorgou, Marina Morais-Almeida, Mario Nagaraju, Karthik Papageorgiou, Effie Pité, Helena Pitrez, Paulo M.C. Pohunek, Petr Roberts, Graham Tsiligianni, Ioanna Turner, Stephen Vijverberg, Susanne Winders, Tonya A. Wong, Gary W.K. Xepapadaki, Paraskevi Zar, Heather J. Papadopoulos, Nikolaos G. |
author_role |
author |
author2 |
Miligkos, Michael Boccabella, Cristina Alimani, Gioulinta S. Custovic, Adnan Deschildre, A. Ducharme, Francine Monique Kalayci, Omer Murray, Clare Garcia, Antonio Nieto Phipatanakul, Wanda Price, David Sheikh, Aziz Agache, Ioana Octavia Bacharier, Leonard Beloukas, Apostolos Bentley, Andrew Bonini, Matteo Castro-Rodriguez, Jose A. De Carlo, Giuseppe Craig, Timothy Diamant, Zuzana Feleszko, Wojciech Felton, Tim Gern, James E. Grigg, Jonathan Hedlin, Gunilla Hossny, Elham M. Ierodiakonou, Despo Jartti, Tuomas Kaplan, Alan Lemanske, Robert F. Le Souëf, Peter N. Mäkelä, Mika J. Mathioudakis, Georgios A. Matricardi, Paolo Mitrogiorgou, Marina Morais-Almeida, Mario Nagaraju, Karthik Papageorgiou, Effie Pité, Helena Pitrez, Paulo M.C. Pohunek, Petr Roberts, Graham Tsiligianni, Ioanna Turner, Stephen Vijverberg, Susanne Winders, Tonya A. Wong, Gary W.K. Xepapadaki, Paraskevi Zar, Heather J. Papadopoulos, Nikolaos G. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Mathioudakis, Alexander G. Miligkos, Michael Boccabella, Cristina Alimani, Gioulinta S. Custovic, Adnan Deschildre, A. Ducharme, Francine Monique Kalayci, Omer Murray, Clare Garcia, Antonio Nieto Phipatanakul, Wanda Price, David Sheikh, Aziz Agache, Ioana Octavia Bacharier, Leonard Beloukas, Apostolos Bentley, Andrew Bonini, Matteo Castro-Rodriguez, Jose A. De Carlo, Giuseppe Craig, Timothy Diamant, Zuzana Feleszko, Wojciech Felton, Tim Gern, James E. Grigg, Jonathan Hedlin, Gunilla Hossny, Elham M. Ierodiakonou, Despo Jartti, Tuomas Kaplan, Alan Lemanske, Robert F. Le Souëf, Peter N. Mäkelä, Mika J. Mathioudakis, Georgios A. Matricardi, Paolo Mitrogiorgou, Marina Morais-Almeida, Mario Nagaraju, Karthik Papageorgiou, Effie Pité, Helena Pitrez, Paulo M.C. Pohunek, Petr Roberts, Graham Tsiligianni, Ioanna Turner, Stephen Vijverberg, Susanne Winders, Tonya A. Wong, Gary W.K. Xepapadaki, Paraskevi Zar, Heather J. Papadopoulos, Nikolaos G. |
dc.subject.por.fl_str_mv |
asthma paediatric thoracic medicine paediatrics thoracic medicine Medicine(all) |
topic |
asthma paediatric thoracic medicine paediatrics thoracic medicine Medicine(all) |
description |
Funding Information: AGM was supported by the National Institute of Health Research Manchester Biomedical Research Centre (NIHR Manchester BRC). We thank Mrs Maria Kritikou for excellent administrative support of the study Publisher Copyright: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Copyright: Copyright 2021 Elsevier B.V., All rights reserved. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-23T22:20:33Z 2021-07-02 2021-07-02T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
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eng |
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eng |
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2044-6055 PURE: 32497760 https://doi.org/10.1136/bmjopen-2020-048338 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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