Integration of Stemness Gene Signatures Reveals Core Functional Modules of Stem Cells and Potential Novel Stemness Genes

Detalhes bibliográficos
Autor(a) principal: Barata, Tânia
Data de Publicação: 2023
Outros Autores: Duarte, Isabel, Futschik, Matthias E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/151628
Resumo: Funding: This work was supported by the Portuguese Foundation for Science and Technology (Fundação para a Ciência e Tecnologia, FCT) through the research project grant (EXPL/CCI-BIO/1650/2021) to M.E.F. I.D. was supported by FCT through the contract 2021.00238.CEECIND.
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spelling Integration of Stemness Gene Signatures Reveals Core Functional Modules of Stem Cells and Potential Novel Stemness Genesdata integrationgene signaturesstem cellsstemnessGeneticsGenetics(clinical)Funding: This work was supported by the Portuguese Foundation for Science and Technology (Fundação para a Ciência e Tecnologia, FCT) through the research project grant (EXPL/CCI-BIO/1650/2021) to M.E.F. I.D. was supported by FCT through the contract 2021.00238.CEECIND.Stem cells encompass a variety of different cell types which converge on the dual capacity to self-renew and differentiate into one or more lineages. These characteristic features are key for the involvement of stem cells in crucial biological processes such as development and ageing. To decipher their underlying genetic substrate, it is important to identify so-called stemness genes that are common to different stem cell types and are consistently identified across different studies. In this meta-analysis, 21 individual stemness signatures for humans and another 21 for mice, obtained from a variety of stem cell types and experimental techniques, were compared. Although we observed biological and experimental variability, a highly significant overlap between gene signatures was identified. This enabled us to define integrated stemness signatures (ISSs) comprised of genes frequently occurring among individual stemness signatures. Such integrated signatures help to exclude false positives that can compromise individual studies and can provide a more robust basis for investigation. To gain further insights into the relevance of ISSs, their genes were functionally annotated and connected within a molecular interaction network. Most importantly, the present analysis points to the potential roles of several less well-studied genes in stemness and thus provides promising candidates for further experimental validation.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBarata, TâniaDuarte, IsabelFutschik, Matthias E.2023-04-05T22:18:17Z2023-03-182023-03-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/151628eng0920-8569PURE: 57709025https://doi.org/10.3390/genes14030745info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:34:05Zoai:run.unl.pt:10362/151628Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:40.118868Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Integration of Stemness Gene Signatures Reveals Core Functional Modules of Stem Cells and Potential Novel Stemness Genes
title Integration of Stemness Gene Signatures Reveals Core Functional Modules of Stem Cells and Potential Novel Stemness Genes
spellingShingle Integration of Stemness Gene Signatures Reveals Core Functional Modules of Stem Cells and Potential Novel Stemness Genes
Barata, Tânia
data integration
gene signatures
stem cells
stemness
Genetics
Genetics(clinical)
title_short Integration of Stemness Gene Signatures Reveals Core Functional Modules of Stem Cells and Potential Novel Stemness Genes
title_full Integration of Stemness Gene Signatures Reveals Core Functional Modules of Stem Cells and Potential Novel Stemness Genes
title_fullStr Integration of Stemness Gene Signatures Reveals Core Functional Modules of Stem Cells and Potential Novel Stemness Genes
title_full_unstemmed Integration of Stemness Gene Signatures Reveals Core Functional Modules of Stem Cells and Potential Novel Stemness Genes
title_sort Integration of Stemness Gene Signatures Reveals Core Functional Modules of Stem Cells and Potential Novel Stemness Genes
author Barata, Tânia
author_facet Barata, Tânia
Duarte, Isabel
Futschik, Matthias E.
author_role author
author2 Duarte, Isabel
Futschik, Matthias E.
author2_role author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Barata, Tânia
Duarte, Isabel
Futschik, Matthias E.
dc.subject.por.fl_str_mv data integration
gene signatures
stem cells
stemness
Genetics
Genetics(clinical)
topic data integration
gene signatures
stem cells
stemness
Genetics
Genetics(clinical)
description Funding: This work was supported by the Portuguese Foundation for Science and Technology (Fundação para a Ciência e Tecnologia, FCT) through the research project grant (EXPL/CCI-BIO/1650/2021) to M.E.F. I.D. was supported by FCT through the contract 2021.00238.CEECIND.
publishDate 2023
dc.date.none.fl_str_mv 2023-04-05T22:18:17Z
2023-03-18
2023-03-18T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/151628
url http://hdl.handle.net/10362/151628
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0920-8569
PURE: 57709025
https://doi.org/10.3390/genes14030745
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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