PEDOT-Coated PLA Fibers Electrospun from Solutions Incorporating Fe(III)Tosylate in Different Solvents by Vapor-Phase Polymerization for Neural Regeneration

Detalhes bibliográficos
Autor(a) principal: Pires, Laura S.
Data de Publicação: 2023
Outros Autores: Melo, Diogo S., Borges, João P., Henriques, Célia R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/162711
Resumo: This research was co-financed by FEDER, European funds, through the COMPETE 2020 POCI and PORL and National Funds through FCT, Portuguese Foundation for Science and Technology and POR Lisboa2020, under the projects PIDDAC (POCI-01-0145-FEDER-007688, reference UIDB/50025/2020–2023) and PTDC/CTMCOM/32606/2017 (NEURiTES). Publisher Copyright: © 2023 by the authors.
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spelling PEDOT-Coated PLA Fibers Electrospun from Solutions Incorporating Fe(III)Tosylate in Different Solvents by Vapor-Phase Polymerization for Neural RegenerationconductivityelectrospinningFe(III)Tosylateneural regenerationPEDOTSH-SY5Y neuronal growthvapor-phase polymerizationChemistry(all)Polymers and PlasticsSDG 7 - Affordable and Clean EnergySDG 9 - Industry, Innovation, and InfrastructureSDG 12 - Responsible Consumption and ProductionThis research was co-financed by FEDER, European funds, through the COMPETE 2020 POCI and PORL and National Funds through FCT, Portuguese Foundation for Science and Technology and POR Lisboa2020, under the projects PIDDAC (POCI-01-0145-FEDER-007688, reference UIDB/50025/2020–2023) and PTDC/CTMCOM/32606/2017 (NEURiTES). Publisher Copyright: © 2023 by the authors.Therapeutic solutions for injuries in the peripheral nervous system are limited and not existing in the case of the central nervous system. The electrical stimulation of cells through a cell-supporting conductive scaffold may contribute to new therapeutic solutions for nerve regeneration. In this work, biocompatible Polylactic acid (PLA) fibrous scaffolds incorporating Fe(III)Tosylate (FeTos) were produced by electrospinning a mixture of PLA/FeTos solutions towards a rotating cylinder, inducing fiber alignment. Fibers were coated with the conductive polymer Poly(3,4 ethylenedioxythiophene) (PEDOT) formed by vapor-phase polymerization of EDOT at 70 °C for 2 h. Different solvents (ETH, DMF and THF) were used as FeTos solvents to investigate the impact on the scaffold’s conductivity. Scaffold conductivity was estimated to be as high as 1.50 × 10−1 S/cm when FeTos was dissolved in DMF. In vitro tests were performed to evaluate possible scaffold cytotoxicity, following ISO 10993-5, revealing no cytotoxic effects. Differentiation and growth of cells from the neural cell line SH-SY5Y seeded on the scaffolds were also assessed, with neuritic extensions observed in cells differentiated in neurons with retinoic acid. These extensions tended to follow the preferential alignment of the scaffold fibers.DCM - Departamento de Ciência dos MateriaisDF – Departamento de FísicaCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)RUNPires, Laura S.Melo, Diogo S.Borges, João P.Henriques, Célia R.2024-01-24T17:02:20Z2023-10-052023-10-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article17application/pdfhttp://hdl.handle.net/10362/162711eng2073-4360PURE: 81996918https://doi.org/10.3390/polym15194004info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:45:40Zoai:run.unl.pt:10362/162711Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:02.249519Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv PEDOT-Coated PLA Fibers Electrospun from Solutions Incorporating Fe(III)Tosylate in Different Solvents by Vapor-Phase Polymerization for Neural Regeneration
title PEDOT-Coated PLA Fibers Electrospun from Solutions Incorporating Fe(III)Tosylate in Different Solvents by Vapor-Phase Polymerization for Neural Regeneration
spellingShingle PEDOT-Coated PLA Fibers Electrospun from Solutions Incorporating Fe(III)Tosylate in Different Solvents by Vapor-Phase Polymerization for Neural Regeneration
Pires, Laura S.
conductivity
electrospinning
Fe(III)Tosylate
neural regeneration
PEDOT
SH-SY5Y neuronal growth
vapor-phase polymerization
Chemistry(all)
Polymers and Plastics
SDG 7 - Affordable and Clean Energy
SDG 9 - Industry, Innovation, and Infrastructure
SDG 12 - Responsible Consumption and Production
title_short PEDOT-Coated PLA Fibers Electrospun from Solutions Incorporating Fe(III)Tosylate in Different Solvents by Vapor-Phase Polymerization for Neural Regeneration
title_full PEDOT-Coated PLA Fibers Electrospun from Solutions Incorporating Fe(III)Tosylate in Different Solvents by Vapor-Phase Polymerization for Neural Regeneration
title_fullStr PEDOT-Coated PLA Fibers Electrospun from Solutions Incorporating Fe(III)Tosylate in Different Solvents by Vapor-Phase Polymerization for Neural Regeneration
title_full_unstemmed PEDOT-Coated PLA Fibers Electrospun from Solutions Incorporating Fe(III)Tosylate in Different Solvents by Vapor-Phase Polymerization for Neural Regeneration
title_sort PEDOT-Coated PLA Fibers Electrospun from Solutions Incorporating Fe(III)Tosylate in Different Solvents by Vapor-Phase Polymerization for Neural Regeneration
author Pires, Laura S.
author_facet Pires, Laura S.
Melo, Diogo S.
Borges, João P.
Henriques, Célia R.
author_role author
author2 Melo, Diogo S.
Borges, João P.
Henriques, Célia R.
author2_role author
author
author
dc.contributor.none.fl_str_mv DCM - Departamento de Ciência dos Materiais
DF – Departamento de Física
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
RUN
dc.contributor.author.fl_str_mv Pires, Laura S.
Melo, Diogo S.
Borges, João P.
Henriques, Célia R.
dc.subject.por.fl_str_mv conductivity
electrospinning
Fe(III)Tosylate
neural regeneration
PEDOT
SH-SY5Y neuronal growth
vapor-phase polymerization
Chemistry(all)
Polymers and Plastics
SDG 7 - Affordable and Clean Energy
SDG 9 - Industry, Innovation, and Infrastructure
SDG 12 - Responsible Consumption and Production
topic conductivity
electrospinning
Fe(III)Tosylate
neural regeneration
PEDOT
SH-SY5Y neuronal growth
vapor-phase polymerization
Chemistry(all)
Polymers and Plastics
SDG 7 - Affordable and Clean Energy
SDG 9 - Industry, Innovation, and Infrastructure
SDG 12 - Responsible Consumption and Production
description This research was co-financed by FEDER, European funds, through the COMPETE 2020 POCI and PORL and National Funds through FCT, Portuguese Foundation for Science and Technology and POR Lisboa2020, under the projects PIDDAC (POCI-01-0145-FEDER-007688, reference UIDB/50025/2020–2023) and PTDC/CTMCOM/32606/2017 (NEURiTES). Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-05
2023-10-05T00:00:00Z
2024-01-24T17:02:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/162711
url http://hdl.handle.net/10362/162711
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2073-4360
PURE: 81996918
https://doi.org/10.3390/polym15194004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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