Costunolide and parthenolide

Detalhes bibliográficos
Autor(a) principal: Ávila-Gálvez, María Ángeles
Data de Publicação: 2023
Outros Autores: Marques, Daniela, Figueira, Inês, Cankar, Katarina, Bosch, Dirk, Brito, Maria Alexandra, dos Santos, Cláudia Nunes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158261
Resumo: Funding Information: This work was supported by the EU Horizon 2020 research & innovation programme (H2020-NMBP-BIO-2017) (grant number 760891). iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is co funded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged. CNS acknowledges European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No 804229. Authors would like to acknowledge FCT for financial institutional support (UIDB/04138/2020 and UIDP/04138/2020) and support of DM (2021.05505. BD) and IF (2022.00151. CEECIND). Funding Information: This work was supported by the EU Horizon 2020 research & innovation programme ( H2020-NMBP-BIO-2017 ) (grant number 760891 ). iNOVA4Health Research Unit ( LISBOA-01-0145-FEDER-007344 ), which is co funded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged. CNS acknowledges European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program under grant agreement No 804229. Authors would like to acknowledge FCT for financial institutional support ( UIDB/04138/2020 and UIDP/04138/2020 ) and support of DM ( 2021.05505. BD ) and IF ( 2022.00151 . CEECIND). Publisher Copyright: © 2023 The Authors
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spelling Costunolide and parthenolideNovel blood-brain barrier permeable sesquiterpene lactones to improve barrier tightnessABC transportersAdherens junctionsBBB transportCostunolideParthenolideTight junctionsPharmacologyFunding Information: This work was supported by the EU Horizon 2020 research & innovation programme (H2020-NMBP-BIO-2017) (grant number 760891). iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is co funded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged. CNS acknowledges European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No 804229. Authors would like to acknowledge FCT for financial institutional support (UIDB/04138/2020 and UIDP/04138/2020) and support of DM (2021.05505. BD) and IF (2022.00151. CEECIND). Funding Information: This work was supported by the EU Horizon 2020 research & innovation programme ( H2020-NMBP-BIO-2017 ) (grant number 760891 ). iNOVA4Health Research Unit ( LISBOA-01-0145-FEDER-007344 ), which is co funded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged. CNS acknowledges European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program under grant agreement No 804229. Authors would like to acknowledge FCT for financial institutional support ( UIDB/04138/2020 and UIDP/04138/2020 ) and support of DM ( 2021.05505. BD ) and IF ( 2022.00151 . CEECIND). Publisher Copyright: © 2023 The AuthorsSesquiterpene lactones - such as those found in chicory - are considered promising bioactive compounds. These small molecules have shown several health benefits for various diseases, including brain disorders. However, it is unknown whether these compounds can cross the blood-brain barrier (BBB), and which could be the effects on brain microvascular endothelial cells. We show that six sesquiterpene lactones evaluated in an in vitro model of the BBB have different capacities to be transported through the barrier. Costunolide presented more than 20 % of transport while lactucin, 11β-13-dihydrolactucin, 11β-13-dihydrolactucopicrin, and parthenolide presented between 10 % and 20 %, whilst almost no transport was detected for lactucopicrin. Furthermore, costunolide and parthenolide reduced P-gp ABC transporter expression alongside an increase in caveolin-1, the main protein of caveolae. Remarkably, these two compounds improved barrier tightness by increasing the expression of both tight and adherens junctions. These findings open a new avenue to explore costunolide and parthenolide as promising compounds for brain therapies.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSRUNÁvila-Gálvez, María ÁngelesMarques, DanielaFigueira, InêsCankar, KatarinaBosch, DirkBrito, Maria Alexandrados Santos, Cláudia Nunes2023-09-25T22:19:21Z2023-112023-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/158261eng0753-3322PURE: 72015043https://doi.org/10.1016/j.biopha.2023.115413info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:30Zoai:run.unl.pt:10362/158261Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:02.322367Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Costunolide and parthenolide
Novel blood-brain barrier permeable sesquiterpene lactones to improve barrier tightness
title Costunolide and parthenolide
spellingShingle Costunolide and parthenolide
Ávila-Gálvez, María Ángeles
ABC transporters
Adherens junctions
BBB transport
Costunolide
Parthenolide
Tight junctions
Pharmacology
title_short Costunolide and parthenolide
title_full Costunolide and parthenolide
title_fullStr Costunolide and parthenolide
title_full_unstemmed Costunolide and parthenolide
title_sort Costunolide and parthenolide
author Ávila-Gálvez, María Ángeles
author_facet Ávila-Gálvez, María Ángeles
Marques, Daniela
Figueira, Inês
Cankar, Katarina
Bosch, Dirk
Brito, Maria Alexandra
dos Santos, Cláudia Nunes
author_role author
author2 Marques, Daniela
Figueira, Inês
Cankar, Katarina
Bosch, Dirk
Brito, Maria Alexandra
dos Santos, Cláudia Nunes
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
iNOVA4Health - pólo NMS
RUN
dc.contributor.author.fl_str_mv Ávila-Gálvez, María Ángeles
Marques, Daniela
Figueira, Inês
Cankar, Katarina
Bosch, Dirk
Brito, Maria Alexandra
dos Santos, Cláudia Nunes
dc.subject.por.fl_str_mv ABC transporters
Adherens junctions
BBB transport
Costunolide
Parthenolide
Tight junctions
Pharmacology
topic ABC transporters
Adherens junctions
BBB transport
Costunolide
Parthenolide
Tight junctions
Pharmacology
description Funding Information: This work was supported by the EU Horizon 2020 research & innovation programme (H2020-NMBP-BIO-2017) (grant number 760891). iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is co funded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged. CNS acknowledges European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No 804229. Authors would like to acknowledge FCT for financial institutional support (UIDB/04138/2020 and UIDP/04138/2020) and support of DM (2021.05505. BD) and IF (2022.00151. CEECIND). Funding Information: This work was supported by the EU Horizon 2020 research & innovation programme ( H2020-NMBP-BIO-2017 ) (grant number 760891 ). iNOVA4Health Research Unit ( LISBOA-01-0145-FEDER-007344 ), which is co funded by Fundação para a Ciência e Tecnologia (FCT) / Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged. CNS acknowledges European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program under grant agreement No 804229. Authors would like to acknowledge FCT for financial institutional support ( UIDB/04138/2020 and UIDP/04138/2020 ) and support of DM ( 2021.05505. BD ) and IF ( 2022.00151 . CEECIND). Publisher Copyright: © 2023 The Authors
publishDate 2023
dc.date.none.fl_str_mv 2023-09-25T22:19:21Z
2023-11
2023-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158261
url http://hdl.handle.net/10362/158261
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0753-3322
PURE: 72015043
https://doi.org/10.1016/j.biopha.2023.115413
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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