Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin

Detalhes bibliográficos
Autor(a) principal: Querido, Micaela Machado
Data de Publicação: 2021
Outros Autores: Paulo, Ivo, Hariharakrishnan, Sriram, Rocha, Daniel, Barbosa, Nuno, Galhano dos Santos, Rui, Bordado, João Moura, Teixeira, João Paulo, Pereira, Cristiana Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/7919
Resumo: This article belongs to the Special Issue Nature Inspired Antibiotic Adjuvants to Face the Problem of Multidrug Resistance and Biofilm Infections
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spelling Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and CurcuminAntimicrobialColophonyCurcuminCytotoxicityPaintSelf-DisinfectingToxicologiaThis article belongs to the Special Issue Nature Inspired Antibiotic Adjuvants to Face the Problem of Multidrug Resistance and Biofilm InfectionsThe risk of infection arising from indirect sources-namely, contaminated surfaces-has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted. In this work, wall-paints with self-disinfecting properties were developed with the scope of being applied in environments prone to contamination, such as those at healthcare settings. Our approach was to develop new paint formulations containing two natural plant-based products with known antimicrobial activity-colophony (CLF) and curcumin (CUR). The natural substances were separately incorporated on a commercial paint and their antibacterial activity was evaluated with several bacterial species following ISO 22196. To assess the paints' safety, cytotoxicity tests were performed on HaCaT and A549 cell lines, using tests on extracts and direct contact tests, as suggested by the standardized protocol ISO 10993. In general, both paints containing CLF and CUR were able to reduce the bacterial growth after 24 h, compared with the control, the commercial unmodified paint. Colophony was even able to reduce the number of culturable bacteria by over 2 log for Staphylococcus aureus, Escherichia coli, and Bacillus cereus. Regarding the cytotoxicity tests performed (WST-1, NRU, and LDH), both formulations revealed promising results regardless of the methodology used.This research was funded by Programa Operacional Competitividade e Internacionaliza‐ ção-COMPETE2020/FEDER, towards the project B‐Safecoat (POCI‐01‐0247‐FEDER‐017875), and by FCT (Fundação para a Ciência e Tecnologia) through the PhD grant awarded to M.M.Q. (SFRH/BD/130203/2017).MDPIRepositório Científico do Instituto Nacional de SaúdeQuerido, Micaela MachadoPaulo, IvoHariharakrishnan, SriramRocha, DanielBarbosa, NunoGalhano dos Santos, RuiBordado, João MouraTeixeira, João PauloPereira, Cristiana Costa2022-02-03T15:59:48Z2021-11-052021-11-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7919engAntibiotics (Basel). 2021 Nov 5;10(11):1351. doi: 10.3390/antibiotics101113512079-638210.3390/antibiotics10111351info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:16Zoai:repositorio.insa.pt:10400.18/7919Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:31.529410Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
spellingShingle Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
Querido, Micaela Machado
Antimicrobial
Colophony
Curcumin
Cytotoxicity
Paint
Self-Disinfecting
Toxicologia
title_short Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_full Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_fullStr Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_full_unstemmed Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
title_sort Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin
author Querido, Micaela Machado
author_facet Querido, Micaela Machado
Paulo, Ivo
Hariharakrishnan, Sriram
Rocha, Daniel
Barbosa, Nuno
Galhano dos Santos, Rui
Bordado, João Moura
Teixeira, João Paulo
Pereira, Cristiana Costa
author_role author
author2 Paulo, Ivo
Hariharakrishnan, Sriram
Rocha, Daniel
Barbosa, Nuno
Galhano dos Santos, Rui
Bordado, João Moura
Teixeira, João Paulo
Pereira, Cristiana Costa
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Querido, Micaela Machado
Paulo, Ivo
Hariharakrishnan, Sriram
Rocha, Daniel
Barbosa, Nuno
Galhano dos Santos, Rui
Bordado, João Moura
Teixeira, João Paulo
Pereira, Cristiana Costa
dc.subject.por.fl_str_mv Antimicrobial
Colophony
Curcumin
Cytotoxicity
Paint
Self-Disinfecting
Toxicologia
topic Antimicrobial
Colophony
Curcumin
Cytotoxicity
Paint
Self-Disinfecting
Toxicologia
description This article belongs to the Special Issue Nature Inspired Antibiotic Adjuvants to Face the Problem of Multidrug Resistance and Biofilm Infections
publishDate 2021
dc.date.none.fl_str_mv 2021-11-05
2021-11-05T00:00:00Z
2022-02-03T15:59:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/7919
url http://hdl.handle.net/10400.18/7919
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antibiotics (Basel). 2021 Nov 5;10(11):1351. doi: 10.3390/antibiotics10111351
2079-6382
10.3390/antibiotics10111351
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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