Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

• Autor(a) principal: Lenza, Maria Pia
• Data de Publicação: 2023
• Outros Autores: Egia-Mendikute, Leire, Antoñana-Vildosola, Asier, Soares, Cátia O., Coelho, Helena, Corzana, Francisco, Bosch, Alexandre, Manisha, Prodhi, Quintana, Jon Imanol, Oyenarte, Iker, Unione, Luca, Moure, María Jesús, Azkargorta, Mikel, Atxabal, Unai, Sobczak, Klaudia, Elortza, Felix, Sutherland, James D., Barrio, Rosa, Marcelo, Filipa, Jiménez-Barbero, Jesús, Palazon, Asis, Ereño-Orbea, June
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/154850
• topic: Chemistry(all); Biochemistry, Genetics and Molecular Biology(all); Physics and Astronomy(all); SDG 3 - Good Health and Well-being

Funding Information: X-ray diffraction experiments described in this paper were performed using beamlines XALOC synchrotron at ALBA (Spain) and PXIII in Swiss Light Source (Switzerland). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project No 22161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). F.M. and J.J.-B. acknowledge to the European funding for the GLYCOTwinning project (No. 101079417) and -COST Action GLYCONANOPROBES. A.P.’s research is funded by “La Caixa” Foundation (HR21-00925), AECC (LABAE211744PALA), Fundación FERO, Ikerbasque, and BIOEF EITB MARATOIA BIO19/CP/002. We thank Agencia Estatal de Investigación of Spain for grants PID2019-107956RA-I00 (A.P.), PID2019-107770RA-I00 (J.E.-O.), RTI2018-099592-B-C21 (F.C.), ID2020-114178GB (R.B. and J.D.S.), RYC2018-024183-I (A.P.), and the Severo Ochoa Center of Excellence Accreditation CEX2021-001136-S, all funded by MCIN/AEI/10.13039/501100011033 and by El FSE invierte en tu futuro, as well as CIBERES, and initiative of Instituto de Salud Carlos III (ISCIII, Spain) A.A.-V. receives funding from “La Caixa” Foundation (ID 100010434, LCF/BQ/DR20/11790022). A. B. (AECC Bizkaia Scientific Foundation, PRDVZ19003BOSC). F.C. acknowledges the Mizutani Foundation for Glycoscience (Grant 220115). Publisher Copyright: © 2023, The Author(s).