Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.8/8551 |
Resumo: | Acknowledgments This work was supported by FCT (Fundação para a Ciência e Tecnologia) through the grants SFRH/BD/140191/2018; SFRH/BPD/112111/2015, SFRH/BD/128657/2017, SFRH/BD/141056/2018; SFRH/BPD/97701/2013, PD/BDE/127836/2016, and the projects PTDC/EMS-TEC/5422/2014_ADAPTPROSTHESIS and NORTE-01- 0145-FEDER-000018-HAMaBICo. Additionally, this work was supported by FCT with the reference project UID/EEA/04436/2013, by FEDER funds through the COMPETE 2020 – Programa Operacional Competitividade e Internacionalização (POCI) with the reference project POCI-01-0145-FEDER-006941. |
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Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical propertiesMulti-material cellular structuresSelective Laser MeltingPress and SinteringTi6Al4Vβ-Tricalcium PhosphateAcknowledgments This work was supported by FCT (Fundação para a Ciência e Tecnologia) through the grants SFRH/BD/140191/2018; SFRH/BPD/112111/2015, SFRH/BD/128657/2017, SFRH/BD/141056/2018; SFRH/BPD/97701/2013, PD/BDE/127836/2016, and the projects PTDC/EMS-TEC/5422/2014_ADAPTPROSTHESIS and NORTE-01- 0145-FEDER-000018-HAMaBICo. Additionally, this work was supported by FCT with the reference project UID/EEA/04436/2013, by FEDER funds through the COMPETE 2020 – Programa Operacional Competitividade e Internacionalização (POCI) with the reference project POCI-01-0145-FEDER-006941.Load-bearing implants success is strongly dependent on several physical and chemical properties that are known to drive cellular response. In this work, multi-material β-TCP-Ti6Al4V cellular structures were designed to combine Ti6Al4V mechanical properties and β-Tricalcium Phosphate bioactivity, in order to promote bone ingrowth as the bioactive material is being absorbed and replaced by newly formed bone. In this sense, the produced structures were characterized regarding roughness, wettability, β-TCP quantity and quality inside the structures after fabrication and the pH measured during cell culture (as consequence of β-TCP dissolution) and those aspects were correlated with cellular viability, distribution, morphology and proliferation. These structures displayed a hydrophilic behavior and results showed that the addition of β-TCP to these cellular structures led to an alkalization of the medium, aspect that significantly influences the cellular response. Higher impregnation ratios were found more adequate for lowering the media pH and toxicity, and thus enhance cell adhesion and proliferation.IC-OnlineCosta, M.M.Lima, R.Melo-Fonseca, F.Bartolomeu, F.Alves, N.Miranda, A.Gasik, M.Silva, F.S.Silva, N.A.Miranda, G.2023-05-31T14:58:25Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8551engM.M. Costa, R. Lima, F. Melo-Fonseca, F. Bartolomeu, N. Alves, A. Miranda, M. Gasik, F.S. Silva, N.A. Silva, G. Miranda, Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties, Materials Science and Engineering: C, Volume 98, 2019, Pages 705-716, ISSN 0928-4931, https://doi.org/10.1016/j.msec.2019.01.016.0928-4931https://doi.org/10.1016/j.msec.2019.01.0161873-0191info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:57:35Zoai:iconline.ipleiria.pt:10400.8/8551Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:14.822467Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties |
| title |
Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties |
| spellingShingle |
Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties Costa, M.M. Multi-material cellular structures Selective Laser Melting Press and Sintering Ti6Al4V β-Tricalcium Phosphate |
| title_short |
Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties |
| title_full |
Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties |
| title_fullStr |
Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties |
| title_full_unstemmed |
Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties |
| title_sort |
Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties |
| author |
Costa, M.M. |
| author_facet |
Costa, M.M. Lima, R. Melo-Fonseca, F. Bartolomeu, F. Alves, N. Miranda, A. Gasik, M. Silva, F.S. Silva, N.A. Miranda, G. |
| author_role |
author |
| author2 |
Lima, R. Melo-Fonseca, F. Bartolomeu, F. Alves, N. Miranda, A. Gasik, M. Silva, F.S. Silva, N.A. Miranda, G. |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
IC-Online |
| dc.contributor.author.fl_str_mv |
Costa, M.M. Lima, R. Melo-Fonseca, F. Bartolomeu, F. Alves, N. Miranda, A. Gasik, M. Silva, F.S. Silva, N.A. Miranda, G. |
| dc.subject.por.fl_str_mv |
Multi-material cellular structures Selective Laser Melting Press and Sintering Ti6Al4V β-Tricalcium Phosphate |
| topic |
Multi-material cellular structures Selective Laser Melting Press and Sintering Ti6Al4V β-Tricalcium Phosphate |
| description |
Acknowledgments This work was supported by FCT (Fundação para a Ciência e Tecnologia) through the grants SFRH/BD/140191/2018; SFRH/BPD/112111/2015, SFRH/BD/128657/2017, SFRH/BD/141056/2018; SFRH/BPD/97701/2013, PD/BDE/127836/2016, and the projects PTDC/EMS-TEC/5422/2014_ADAPTPROSTHESIS and NORTE-01- 0145-FEDER-000018-HAMaBICo. Additionally, this work was supported by FCT with the reference project UID/EEA/04436/2013, by FEDER funds through the COMPETE 2020 – Programa Operacional Competitividade e Internacionalização (POCI) with the reference project POCI-01-0145-FEDER-006941. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2023-05-31T14:58:25Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.8/8551 |
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http://hdl.handle.net/10400.8/8551 |
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eng |
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eng |
| dc.relation.none.fl_str_mv |
M.M. Costa, R. Lima, F. Melo-Fonseca, F. Bartolomeu, N. Alves, A. Miranda, M. Gasik, F.S. Silva, N.A. Silva, G. Miranda, Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties, Materials Science and Engineering: C, Volume 98, 2019, Pages 705-716, ISSN 0928-4931, https://doi.org/10.1016/j.msec.2019.01.016. 0928-4931 https://doi.org/10.1016/j.msec.2019.01.016 1873-0191 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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