The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/152256 |
Resumo: | Funding: We thank William Thompson for the excellent technical support. We also thank Prof. Elizabeth Glass (The Roslin Institute, UK) for providing the Sahiwal and Nelore DNA samples, Prof. Tomohiro Kono (Tokyo University of Agriculture, Japan) for providing the Kuchinoshima-Ushi DNA, and Prof. Stephen Hall (University of Lincoln, UK) for the useful comments and for providing peripheral blood from the culled Chillingham cattle. JCS and JAH were supported by the United Kingdom Biotechnology and Biological Sciences Research Council (BBSRC) Institute Strategic Program on Livestock Viral Diseases awarded to The Pirbright Institute. MSG was supported by BBSRC grant BB/J006211/1, BDissecting the functional impact of natural killer cell receptor variation in cattle.^ SK and AMP were supported by the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health. Sequencing of Dominette was supported by the Agricultural Research Service of the United States Department of Agriculture (USDA-ARS) U.S. Meat Animal Research Center, USDA/NRSP8 Cattle Coordinator Funds, and University of California Davis. DMB was supported in part by appropriated project 1265-31000-096-00, BImproving Genetic Predictions in Dairy Animals Using Phenotypic and Genomic Information,^ of the USDA-ARS. DMB and TPLS were also supported by the Agricultural Food Research Initiative (AFRI) competitive grant number 2015-67015- 22970 from the USDA National Institute of Food and Agriculture (NIFA) Animal Health Program. Mention of trade names or commercial products in this article is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the US Department of Agriculture. |
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The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotationC-type lectinKLRAKLRCLeukocyte receptor complexNatural killer cellsNatural killer complexImmunologyGeneticsSDG 3 - Good Health and Well-beingFunding: We thank William Thompson for the excellent technical support. We also thank Prof. Elizabeth Glass (The Roslin Institute, UK) for providing the Sahiwal and Nelore DNA samples, Prof. Tomohiro Kono (Tokyo University of Agriculture, Japan) for providing the Kuchinoshima-Ushi DNA, and Prof. Stephen Hall (University of Lincoln, UK) for the useful comments and for providing peripheral blood from the culled Chillingham cattle. JCS and JAH were supported by the United Kingdom Biotechnology and Biological Sciences Research Council (BBSRC) Institute Strategic Program on Livestock Viral Diseases awarded to The Pirbright Institute. MSG was supported by BBSRC grant BB/J006211/1, BDissecting the functional impact of natural killer cell receptor variation in cattle.^ SK and AMP were supported by the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health. Sequencing of Dominette was supported by the Agricultural Research Service of the United States Department of Agriculture (USDA-ARS) U.S. Meat Animal Research Center, USDA/NRSP8 Cattle Coordinator Funds, and University of California Davis. DMB was supported in part by appropriated project 1265-31000-096-00, BImproving Genetic Predictions in Dairy Animals Using Phenotypic and Genomic Information,^ of the USDA-ARS. DMB and TPLS were also supported by the Agricultural Food Research Initiative (AFRI) competitive grant number 2015-67015- 22970 from the USDA National Institute of Food and Agriculture (NIFA) Animal Health Program. Mention of trade names or commercial products in this article is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the US Department of Agriculture.Natural killer (NK) cells are a diverse population of lymphocytes with a range of biological roles including essential immune functions. NK cell diversity is in part created by the differential expression of cell surface receptors which modulate activation and function, including multiple subfamilies of C-type lectin receptors encoded within the NK complex (NKC). Little is known about the gene content of the NKC beyond rodent and primate lineages, other than it appears to be extremely variable between mammalian groups. We compared the NKC structure between mammalian species using new high-quality draft genome assemblies for cattle and goat; re-annotated sheep, pig, and horse genome assemblies; and the published human, rat, and mouse lemur NKC. The major NKC genes are largely in the equivalent positions in all eight species, with significant independent expansions and deletions between species, allowing us to propose a model for NKC evolution during mammalian radiation. The ruminant species, cattle and goats, have independently evolved a second KLRC locus flanked by KLRA and KLRJ, and a novel KLRH-like gene has acquired an activating tail. This novel gene has duplicated several times within cattle, while other activating receptor genes have been selectively disrupted. Targeted genome enrichment in cattle identified varying levels of allelic polymorphism between the NKC genes concentrated in the predicted extracellular ligand-binding domains. This novel recombination and allelic polymorphism is consistent with NKC evolution under balancing selection, suggesting that this diversity influences individual immune responses and may impact on differential outcomes of pathogen infection and vaccination.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNSchwartz, John C.Gibson, Mark S.Heimeier, DorotheaKoren, SergeyPhillippy, Adam M.Bickhart, Derek M.Smith, Timothy P.L.Medrano, Juan F.Hammond, John A.2023-04-28T22:22:51Z2017-04-012017-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttp://hdl.handle.net/10362/152256eng0093-7711PURE: 59534968https://doi.org/10.1007/s00251-017-0973-yinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:34:37Zoai:run.unl.pt:10362/152256Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:51.273195Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation |
title |
The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation |
spellingShingle |
The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation Schwartz, John C. C-type lectin KLRA KLRC Leukocyte receptor complex Natural killer cells Natural killer complex Immunology Genetics SDG 3 - Good Health and Well-being |
title_short |
The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation |
title_full |
The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation |
title_fullStr |
The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation |
title_full_unstemmed |
The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation |
title_sort |
The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation |
author |
Schwartz, John C. |
author_facet |
Schwartz, John C. Gibson, Mark S. Heimeier, Dorothea Koren, Sergey Phillippy, Adam M. Bickhart, Derek M. Smith, Timothy P.L. Medrano, Juan F. Hammond, John A. |
author_role |
author |
author2 |
Gibson, Mark S. Heimeier, Dorothea Koren, Sergey Phillippy, Adam M. Bickhart, Derek M. Smith, Timothy P.L. Medrano, Juan F. Hammond, John A. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
dc.contributor.author.fl_str_mv |
Schwartz, John C. Gibson, Mark S. Heimeier, Dorothea Koren, Sergey Phillippy, Adam M. Bickhart, Derek M. Smith, Timothy P.L. Medrano, Juan F. Hammond, John A. |
dc.subject.por.fl_str_mv |
C-type lectin KLRA KLRC Leukocyte receptor complex Natural killer cells Natural killer complex Immunology Genetics SDG 3 - Good Health and Well-being |
topic |
C-type lectin KLRA KLRC Leukocyte receptor complex Natural killer cells Natural killer complex Immunology Genetics SDG 3 - Good Health and Well-being |
description |
Funding: We thank William Thompson for the excellent technical support. We also thank Prof. Elizabeth Glass (The Roslin Institute, UK) for providing the Sahiwal and Nelore DNA samples, Prof. Tomohiro Kono (Tokyo University of Agriculture, Japan) for providing the Kuchinoshima-Ushi DNA, and Prof. Stephen Hall (University of Lincoln, UK) for the useful comments and for providing peripheral blood from the culled Chillingham cattle. JCS and JAH were supported by the United Kingdom Biotechnology and Biological Sciences Research Council (BBSRC) Institute Strategic Program on Livestock Viral Diseases awarded to The Pirbright Institute. MSG was supported by BBSRC grant BB/J006211/1, BDissecting the functional impact of natural killer cell receptor variation in cattle.^ SK and AMP were supported by the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health. Sequencing of Dominette was supported by the Agricultural Research Service of the United States Department of Agriculture (USDA-ARS) U.S. Meat Animal Research Center, USDA/NRSP8 Cattle Coordinator Funds, and University of California Davis. DMB was supported in part by appropriated project 1265-31000-096-00, BImproving Genetic Predictions in Dairy Animals Using Phenotypic and Genomic Information,^ of the USDA-ARS. DMB and TPLS were also supported by the Agricultural Food Research Initiative (AFRI) competitive grant number 2015-67015- 22970 from the USDA National Institute of Food and Agriculture (NIFA) Animal Health Program. Mention of trade names or commercial products in this article is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the US Department of Agriculture. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-01 2017-04-01T00:00:00Z 2023-04-28T22:22:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/152256 |
url |
http://hdl.handle.net/10362/152256 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0093-7711 PURE: 59534968 https://doi.org/10.1007/s00251-017-0973-y |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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15 application/pdf |
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