Timing of Spheno-Occipital Synchondrosis Ossification in Children and Adolescents with Cleft Lip and Palate: A Retrospective Case-Control Study

• Autor(a) principal: Vale, Francisco
• Data de Publicação: 2020
• Outros Autores: Francisco, Inês, Lucas, António, Roseiro, Ana, Caramelo, Francisco, Sobral, Adriana
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/106174; https://doi.org/10.3390/ijerph17238889
• topic: cleft lip; cleft palate; cone beam computed tomography; Adolescent; Case-Control Studies; Child; Female; Humans; Male; Occipital Bone; Palate; Retrospective Studies; Sphenoid Bone; Cleft Lip; Cleft Palate; Osteogenesis

Background: Cleft lip and palate (CLP) can a ect the development of the maxilla; which may create a midfacial deficiency as well as an interference of the facial growth pattern and dentofacial esthetics. Objective: This study aimed to estimate the chronological age of complete fusion of the spheno-occipital synchondrosis (SOS) in cleft lip and palate patients and a control group; using cone beam computed tomography (CBCT) images. Methods: In this retrospective study; 125 patients were enrolled (cleft lip and palate group (n = 91); control group (n = 34)). Age comparison was made with a chi-square test; and a Kaplan–Meier analysis determined the median time to reach complete fusion of the spheno-occipital synchondrosis (p < 0.05). Results: The experimental group showed statistically significant di erences in the median time for complete ossification between males and females (p = 0.019). The median time for complete ossification of the spheno-occipital synchondrosis was; for males; 15.0 years in both groups; for females; it was 14.0 years and 13.0 years in the experimental group and in the control group; respectively. Both for males and females; there were no statistically significant di erences between experimental and control groups (p = 0.104). Conclusions: The present study showed no di erences in the ossification of the spheno-occipital synchondrosis between individuals with and without cleft lip and/or palate.