The role of non-standard translation in Candida albicans pathogenesis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/34661 |
Resumo: | Candida albicans typically resides in the human gastrointestinal tract and mucosal membranes as a commensal organism. To adapt and cope with the host immune system, it has evolved a variety of mechanisms of adaptation such as stress-induced mutagenesis and epigenetic regulation. Niche-specific patterns of gene expression also allow the fungus to fine-tune its response to specific microenvironments in the host and switch from harmless commensal to invasive pathogen. Proteome plasticity produced by CUG ambiguity, on the other hand is emerging as a new layer of complexity in C. albicans adaptation, pathogenesis, and drug resistance. Such proteome plasticity is the result of a genetic code alteration where the leucine CUG codon is translated mainly as serine (97%), but maintains some level of leucine (3%) assignment. In this review, we dissect the link between C. albicans non-standard CUG translation, proteome plasticity, host adaptation and pathogenesis. We discuss published work showing how this pathogen uses the fidelity of protein synthesis to spawn novel virulence traits. |
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The role of non-standard translation in Candida albicans pathogenesisCandida albicansDrug resistanceEvolutionGenetic diversityNon-standard translationPathogenesisCandida albicans typically resides in the human gastrointestinal tract and mucosal membranes as a commensal organism. To adapt and cope with the host immune system, it has evolved a variety of mechanisms of adaptation such as stress-induced mutagenesis and epigenetic regulation. Niche-specific patterns of gene expression also allow the fungus to fine-tune its response to specific microenvironments in the host and switch from harmless commensal to invasive pathogen. Proteome plasticity produced by CUG ambiguity, on the other hand is emerging as a new layer of complexity in C. albicans adaptation, pathogenesis, and drug resistance. Such proteome plasticity is the result of a genetic code alteration where the leucine CUG codon is translated mainly as serine (97%), but maintains some level of leucine (3%) assignment. In this review, we dissect the link between C. albicans non-standard CUG translation, proteome plasticity, host adaptation and pathogenesis. We discuss published work showing how this pathogen uses the fidelity of protein synthesis to spawn novel virulence traits.Oxford University Press2022-09-20T10:54:05Z2021-06-01T00:00:00Z2021-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/34661eng1567-135610.1093/femsyr/foab032Bezerra, Ana RitaOliveira, CarlaCorreia, InêsGuimarães, Ana RitaSousa, GonçaloCarvalho, Maria JoãoMoura, GabrielaSantos, Manuel A. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:06:33Zoai:ria.ua.pt:10773/34661Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:05:47.016418Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The role of non-standard translation in Candida albicans pathogenesis |
title |
The role of non-standard translation in Candida albicans pathogenesis |
spellingShingle |
The role of non-standard translation in Candida albicans pathogenesis Bezerra, Ana Rita Candida albicans Drug resistance Evolution Genetic diversity Non-standard translation Pathogenesis |
title_short |
The role of non-standard translation in Candida albicans pathogenesis |
title_full |
The role of non-standard translation in Candida albicans pathogenesis |
title_fullStr |
The role of non-standard translation in Candida albicans pathogenesis |
title_full_unstemmed |
The role of non-standard translation in Candida albicans pathogenesis |
title_sort |
The role of non-standard translation in Candida albicans pathogenesis |
author |
Bezerra, Ana Rita |
author_facet |
Bezerra, Ana Rita Oliveira, Carla Correia, Inês Guimarães, Ana Rita Sousa, Gonçalo Carvalho, Maria João Moura, Gabriela Santos, Manuel A. S. |
author_role |
author |
author2 |
Oliveira, Carla Correia, Inês Guimarães, Ana Rita Sousa, Gonçalo Carvalho, Maria João Moura, Gabriela Santos, Manuel A. S. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Bezerra, Ana Rita Oliveira, Carla Correia, Inês Guimarães, Ana Rita Sousa, Gonçalo Carvalho, Maria João Moura, Gabriela Santos, Manuel A. S. |
dc.subject.por.fl_str_mv |
Candida albicans Drug resistance Evolution Genetic diversity Non-standard translation Pathogenesis |
topic |
Candida albicans Drug resistance Evolution Genetic diversity Non-standard translation Pathogenesis |
description |
Candida albicans typically resides in the human gastrointestinal tract and mucosal membranes as a commensal organism. To adapt and cope with the host immune system, it has evolved a variety of mechanisms of adaptation such as stress-induced mutagenesis and epigenetic regulation. Niche-specific patterns of gene expression also allow the fungus to fine-tune its response to specific microenvironments in the host and switch from harmless commensal to invasive pathogen. Proteome plasticity produced by CUG ambiguity, on the other hand is emerging as a new layer of complexity in C. albicans adaptation, pathogenesis, and drug resistance. Such proteome plasticity is the result of a genetic code alteration where the leucine CUG codon is translated mainly as serine (97%), but maintains some level of leucine (3%) assignment. In this review, we dissect the link between C. albicans non-standard CUG translation, proteome plasticity, host adaptation and pathogenesis. We discuss published work showing how this pathogen uses the fidelity of protein synthesis to spawn novel virulence traits. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-01T00:00:00Z 2021-06 2022-09-20T10:54:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/34661 |
url |
http://hdl.handle.net/10773/34661 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1567-1356 10.1093/femsyr/foab032 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137712633020416 |