Hormone-mediated gene regulation and bioinformatics : learning one from the other
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/8900 |
Resumo: | The ability to manage the constantly growing clinically relevant information in genetics available on the internet is becoming crucial in medical practice. Therefore, training students in teaching environments that develop bioinformatics skills is a particular challenge to medical schools. We present here an instructional approach that potentiates learning of hormone/vitamin mechanisms of action in gene regulation with the acquisition and practice of bioinformatics skills. The activity is integrated within the study of the Endocrine System module. Given a nucleotide sequence of a hormone or vitamin-response element, students use internet databases and tools to find the gene to which it belongs. Subsequently, students search how the corresponding hormone/vitamin influences the expression of that particular gene and how a dysfunctional interaction might cause disease. This activity was presented for four consecutive years to cohorts of 50–60 students/year enrolled in the 2nd year of the medical degree. 90% of the students developed a better understanding of the usefulness of bioinformatics and 98% intend to use web-based resources in the future. Since hormones and vitamins regulate genes of all body organ systems, this activity successfully integrates the whole body physiology of the medical curriculum. |
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Hormone-mediated gene regulation and bioinformatics : learning one from the otherScience & TechnologyThe ability to manage the constantly growing clinically relevant information in genetics available on the internet is becoming crucial in medical practice. Therefore, training students in teaching environments that develop bioinformatics skills is a particular challenge to medical schools. We present here an instructional approach that potentiates learning of hormone/vitamin mechanisms of action in gene regulation with the acquisition and practice of bioinformatics skills. The activity is integrated within the study of the Endocrine System module. Given a nucleotide sequence of a hormone or vitamin-response element, students use internet databases and tools to find the gene to which it belongs. Subsequently, students search how the corresponding hormone/vitamin influences the expression of that particular gene and how a dysfunctional interaction might cause disease. This activity was presented for four consecutive years to cohorts of 50–60 students/year enrolled in the 2nd year of the medical degree. 90% of the students developed a better understanding of the usefulness of bioinformatics and 98% intend to use web-based resources in the future. Since hormones and vitamins regulate genes of all body organ systems, this activity successfully integrates the whole body physiology of the medical curriculum.Public Library of ScienceUniversidade do MinhoSousa, João CarlosCosta, Manuel JoãoPalha, Joana Almeida2007-05-302007-05-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/8900engSOUSA, João Carlos ; COSTA, Manuel João ; PALHA, Joana Almeida - Hormone-mediated gene regulation and bioinformatics."PLoS One" [Em linha]. 2:5 (May 2007) e481. [Consult. 14 Abr. 2009]. Disponível em WWW:<URL:http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0000481>. ISSN 1932-6203.1932-620310.1371/journal.pone.000048117534431http://www.plosone.org/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:47:18Zoai:repositorium.sdum.uminho.pt:1822/8900Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:45:23.948277Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Hormone-mediated gene regulation and bioinformatics : learning one from the other |
title |
Hormone-mediated gene regulation and bioinformatics : learning one from the other |
spellingShingle |
Hormone-mediated gene regulation and bioinformatics : learning one from the other Sousa, João Carlos Science & Technology |
title_short |
Hormone-mediated gene regulation and bioinformatics : learning one from the other |
title_full |
Hormone-mediated gene regulation and bioinformatics : learning one from the other |
title_fullStr |
Hormone-mediated gene regulation and bioinformatics : learning one from the other |
title_full_unstemmed |
Hormone-mediated gene regulation and bioinformatics : learning one from the other |
title_sort |
Hormone-mediated gene regulation and bioinformatics : learning one from the other |
author |
Sousa, João Carlos |
author_facet |
Sousa, João Carlos Costa, Manuel João Palha, Joana Almeida |
author_role |
author |
author2 |
Costa, Manuel João Palha, Joana Almeida |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Sousa, João Carlos Costa, Manuel João Palha, Joana Almeida |
dc.subject.por.fl_str_mv |
Science & Technology |
topic |
Science & Technology |
description |
The ability to manage the constantly growing clinically relevant information in genetics available on the internet is becoming crucial in medical practice. Therefore, training students in teaching environments that develop bioinformatics skills is a particular challenge to medical schools. We present here an instructional approach that potentiates learning of hormone/vitamin mechanisms of action in gene regulation with the acquisition and practice of bioinformatics skills. The activity is integrated within the study of the Endocrine System module. Given a nucleotide sequence of a hormone or vitamin-response element, students use internet databases and tools to find the gene to which it belongs. Subsequently, students search how the corresponding hormone/vitamin influences the expression of that particular gene and how a dysfunctional interaction might cause disease. This activity was presented for four consecutive years to cohorts of 50–60 students/year enrolled in the 2nd year of the medical degree. 90% of the students developed a better understanding of the usefulness of bioinformatics and 98% intend to use web-based resources in the future. Since hormones and vitamins regulate genes of all body organ systems, this activity successfully integrates the whole body physiology of the medical curriculum. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-05-30 2007-05-30T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/8900 |
url |
http://hdl.handle.net/1822/8900 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
SOUSA, João Carlos ; COSTA, Manuel João ; PALHA, Joana Almeida - Hormone-mediated gene regulation and bioinformatics."PLoS One" [Em linha]. 2:5 (May 2007) e481. [Consult. 14 Abr. 2009]. Disponível em WWW:<URL:http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0000481>. ISSN 1932-6203. 1932-6203 10.1371/journal.pone.0000481 17534431 http://www.plosone.org/ |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133018645856256 |