Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015–2018

Detalhes bibliográficos
Autor(a) principal: Bandeira, Teresa
Data de Publicação: 2022
Outros Autores: Carmo, Mafalda, Lopes, Hugo, Gomes, Catarina, Martins, Margarida, Guzman, Carlos, Bangert, Mathieu, Rodrigues, Fernanda, Januário, Gustavo, Tomé, Teresa, Azevedo, Inês
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/59898
Resumo: © 2022 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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spelling Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015–2018PortugalAdministrative dataBurdenHospitalizationsLower respiratory infectionRespiratory syncytial virus© 2022 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Background: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infection (ALRI) in young children and is of considerable burden on healthcare systems. Our study aimed to evaluate ALRI hospitalizations related to RSV in children in Portugal. Methods: We reviewed hospitalizations potentially related to RSV in children aged <5 years from 2015 to 2018, using anonymized administrative data covering all public hospital discharges in mainland Portugal. Three case definitions were considered: (a) RSV-specific, (b) (a) plus unspecified acute bronchiolitis (RSV-specific & Bronchiolitis), and (c) (b) plus unspecified ALRI (RSV-specific & ALRI). Results: A total of 9697 RSV-specific hospitalizations were identified from 2015 to 2018-increasing to 26 062 for RSV-specific & ALRI hospitalizations-of which 74.7% were during seasons 2015/2016-2017/2018 (November-March). Mean hospitalization rates per season were, for RSV-specific, RSV-specific & Bronchiolitis, and RSV-specific & ALRI, respectively, 5.6, 9.4, and 11.8 per 1000 children aged <5 years and 13.4, 22.5, and 25.9 in children aged <2 years. Most RSV-specific hospitalizations occurred in healthy children (94.9%) and in children aged <2 years (96.3%). Annual direct costs of €2.4 million were estimated for RSV-specific hospitalizations-rising to €5.1 million for RSV-specific & ALRI-mostly driven by healthy children (87.6%). Conclusion: RSV is accountable for a substantial number of hospitalizations in children, especially during their first year of life. Hospitalizations are mainly driven by healthy children. The variability of the potential RSV burden across case definitions highlights the need for a universal RSV surveillance system to guide prevention strategies.The study was funded by Sanofi.WileyRepositório da Universidade de LisboaBandeira, TeresaCarmo, MafaldaLopes, HugoGomes, CatarinaMartins, MargaridaGuzman, CarlosBangert, MathieuRodrigues, FernandaJanuário, GustavoTomé, TeresaAzevedo, Inês2023-10-19T11:24:50Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/59898engInfluenza Other Respir Viruses. 2023 Jan;17(1):e130661750-264010.1111/irv.130661750-2659info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:09:03Zoai:repositorio.ul.pt:10451/59898Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:09:36.927670Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015–2018
title Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015–2018
spellingShingle Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015–2018
Bandeira, Teresa
Portugal
Administrative data
Burden
Hospitalizations
Lower respiratory infection
Respiratory syncytial virus
title_short Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015–2018
title_full Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015–2018
title_fullStr Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015–2018
title_full_unstemmed Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015–2018
title_sort Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015–2018
author Bandeira, Teresa
author_facet Bandeira, Teresa
Carmo, Mafalda
Lopes, Hugo
Gomes, Catarina
Martins, Margarida
Guzman, Carlos
Bangert, Mathieu
Rodrigues, Fernanda
Januário, Gustavo
Tomé, Teresa
Azevedo, Inês
author_role author
author2 Carmo, Mafalda
Lopes, Hugo
Gomes, Catarina
Martins, Margarida
Guzman, Carlos
Bangert, Mathieu
Rodrigues, Fernanda
Januário, Gustavo
Tomé, Teresa
Azevedo, Inês
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Bandeira, Teresa
Carmo, Mafalda
Lopes, Hugo
Gomes, Catarina
Martins, Margarida
Guzman, Carlos
Bangert, Mathieu
Rodrigues, Fernanda
Januário, Gustavo
Tomé, Teresa
Azevedo, Inês
dc.subject.por.fl_str_mv Portugal
Administrative data
Burden
Hospitalizations
Lower respiratory infection
Respiratory syncytial virus
topic Portugal
Administrative data
Burden
Hospitalizations
Lower respiratory infection
Respiratory syncytial virus
description © 2022 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-10-19T11:24:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/59898
url http://hdl.handle.net/10451/59898
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Influenza Other Respir Viruses. 2023 Jan;17(1):e13066
1750-2640
10.1111/irv.13066
1750-2659
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134651209482240

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