Zeolite structures loading with an anticancer compound as drug delivery systems

Detalhes bibliográficos
Autor(a) principal: Amorim, Ricardo
Data de Publicação: 2012
Outros Autores: Vilaça, Natália, Martinho, Olga, Reis, R. M., Sardo, Mariana, Rocha, João, Fonseca, António Manuel, Baltazar, Fátima, Neves, Isabel C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/23807
Resumo: The authors are thankful to Dr. A. S. Azevedo for collecting the powder diffraction data.
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spelling Zeolite structures loading with an anticancer compound as drug delivery systemsScience & TechnologyThe authors are thankful to Dr. A. S. Azevedo for collecting the powder diffraction data.Two different structures of zeolites, faujasite (FAU) and Linde type A (LTA), were studied to investigate their suitability for drug delivery systems (DDS). The zeolites in the sodium form (NaY and NaA) were used as hosts for encapsulation of α-cyano-4- hydroxycinnamic acid (CHC). CHC, an experimental anticancer drug, was encapsulated in both zeolites by diffusion in liquid phase. These new drug delivery systems, CHC@zeolite, were characterized by spectroscopic techniques (FTIR, 1H NMR, 13C and 27Al solidstate MAS NMR, and UV−vis), chemical analysis, powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effect of the zeolites and CHC@zeolite drug deliveries on HCT-15 human colon carcinoma cell line viability was evaluated. Both zeolites alone revealed no toxicity to HCT-15 cancer cells. Importantly, CHC@zeolite exhibit an inhibition of cell viability up to 585-fold, when compared to the non-encapsulated drug. These results indicate the potential of the zeolites for drug loading and delivery into cancer cells to induce cell deathO.M. and R.A. are recipients of fellowships (SFRH/BD/36463/2007, SFRH/BI/51118/2010) from Fundação para a Ciência e a Tecnologia (FCT, Portugal). This work was supported by the FCT projects refs PEst-C/ QUI/UI0686/2011, PEst-C/CTM/LA0011/2011, and PTDC/ SAU-FCF/104347/2008, under the scope of “Programa Operacional Temático Factores de Competitividade” (COMPETE) of “Quadro Comunitário de Apoio III” and cofinanced by Fundo Comunitário Europeu FEDER, and the Centre of Chemistry and Life and Health Sciences Research Institute (University of Minho, Portugal).American Chemical Society (ACS)Universidade do MinhoAmorim, RicardoVilaça, NatáliaMartinho, OlgaReis, R. M.Sardo, MarianaRocha, JoãoFonseca, António ManuelBaltazar, FátimaNeves, Isabel C.2012-112012-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/23807eng1932-744710.1021/jp3093868http://pubs.acs.org/doi/ipdf/10.1021/jp3093868info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:36:45Zoai:repositorium.sdum.uminho.pt:1822/23807Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:32:55.888807Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Zeolite structures loading with an anticancer compound as drug delivery systems
title Zeolite structures loading with an anticancer compound as drug delivery systems
spellingShingle Zeolite structures loading with an anticancer compound as drug delivery systems
Amorim, Ricardo
Science & Technology
title_short Zeolite structures loading with an anticancer compound as drug delivery systems
title_full Zeolite structures loading with an anticancer compound as drug delivery systems
title_fullStr Zeolite structures loading with an anticancer compound as drug delivery systems
title_full_unstemmed Zeolite structures loading with an anticancer compound as drug delivery systems
title_sort Zeolite structures loading with an anticancer compound as drug delivery systems
author Amorim, Ricardo
author_facet Amorim, Ricardo
Vilaça, Natália
Martinho, Olga
Reis, R. M.
Sardo, Mariana
Rocha, João
Fonseca, António Manuel
Baltazar, Fátima
Neves, Isabel C.
author_role author
author2 Vilaça, Natália
Martinho, Olga
Reis, R. M.
Sardo, Mariana
Rocha, João
Fonseca, António Manuel
Baltazar, Fátima
Neves, Isabel C.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Amorim, Ricardo
Vilaça, Natália
Martinho, Olga
Reis, R. M.
Sardo, Mariana
Rocha, João
Fonseca, António Manuel
Baltazar, Fátima
Neves, Isabel C.
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description The authors are thankful to Dr. A. S. Azevedo for collecting the powder diffraction data.
publishDate 2012
dc.date.none.fl_str_mv 2012-11
2012-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/23807
url http://hdl.handle.net/1822/23807
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1932-7447
10.1021/jp3093868
http://pubs.acs.org/doi/ipdf/10.1021/jp3093868
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society (ACS)
publisher.none.fl_str_mv American Chemical Society (ACS)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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