Synthesis, characterization and preliminary antibacterial evaluation against Staphylococcus aureus of a new 2,4,5-tri(hetero)arylimidazole derivative based on azaindole heterocycle

• Autor(a) principal: Ramos, Nuna Liliana Pereira
• Data de Publicação: 2022
• Outros Autores: Oliveira, Rui Pedro Soares de, Costa, Susana P. G., Raposo, M. Manuela M.
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://hdl.handle.net/1822/74801
• topic: Imidazole; Synthesis; Antibacterial activity; Staphylococcus aureus

Imidazole derivatives are known for their numerous biological applications, such as antibacterial, antifungal, antioxidant, antiviral, antiparasitic and anticancer, among others. Therefore, several imidazole derivatives have been synthesized and developed in recent years as potential drugs in the treatment of several diseases. In this communication, we report the synthesis of a new imidazole derivative, substituted at positions 2, 4 and 5 with heterocyclic groups, using a simple synthetic methodology and an easy purification procedure. The new compound was characterized by the usual spectroscopic techniques (NMR, UV-Vis absorption and emission). The evaluation of the novel imidazole derivative as a potential antibiotic drug was carried out against the Gram-positive bacterium Staphylococcus aureus, using disk test diffusion method. Results showed a dose-response effect against the bacteria under study, revealing that the rational design of this imidazole derivative is quite promising to improve antibacterial activity of imidazole derivatives.