Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies

Detalhes bibliográficos
Autor(a) principal: Martins, SF
Data de Publicação: 2011
Outros Autores: Reis, RM, Rodrigues, AM, Baltazar, F, Filho, AL
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.23/132
Resumo: Colorectal cancer (CRC) is one of the cancer models and most of the carcinogenic steps are presently well understood. Therefore, successful preventive measures are currently used in medical practice. However, CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nowadays, pathologic stage is a unique and well-recognized prognostic indicator, however, more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment. Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial. Probably the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic therapy. The goal of this review is to critically evaluate the role of angiogenic markers, assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in anti-angiogenic therapie
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spelling Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapiesNeoplasias ColorrectaisFactor de Crescimento Endotelial VascularInibidores da AngiogénesePrognósticoColorectal cancer (CRC) is one of the cancer models and most of the carcinogenic steps are presently well understood. Therefore, successful preventive measures are currently used in medical practice. However, CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nowadays, pathologic stage is a unique and well-recognized prognostic indicator, however, more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment. Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial. Probably the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic therapy. The goal of this review is to critically evaluate the role of angiogenic markers, assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in anti-angiogenic therapieRepositório Científico do Hospital de BragaMartins, SFReis, RMRodrigues, AMBaltazar, FFilho, AL2012-02-08T13:56:46Z2011-01-01T00:00:00Z2011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/132enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:01:38Zoai:repositorio.hospitaldebraga.pt:10400.23/132Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:54:10.538337Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies
title Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies
spellingShingle Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies
Martins, SF
Neoplasias Colorrectais
Factor de Crescimento Endotelial Vascular
Inibidores da Angiogénese
Prognóstico
title_short Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies
title_full Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies
title_fullStr Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies
title_full_unstemmed Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies
title_sort Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies
author Martins, SF
author_facet Martins, SF
Reis, RM
Rodrigues, AM
Baltazar, F
Filho, AL
author_role author
author2 Reis, RM
Rodrigues, AM
Baltazar, F
Filho, AL
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Hospital de Braga
dc.contributor.author.fl_str_mv Martins, SF
Reis, RM
Rodrigues, AM
Baltazar, F
Filho, AL
dc.subject.por.fl_str_mv Neoplasias Colorrectais
Factor de Crescimento Endotelial Vascular
Inibidores da Angiogénese
Prognóstico
topic Neoplasias Colorrectais
Factor de Crescimento Endotelial Vascular
Inibidores da Angiogénese
Prognóstico
description Colorectal cancer (CRC) is one of the cancer models and most of the carcinogenic steps are presently well understood. Therefore, successful preventive measures are currently used in medical practice. However, CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nowadays, pathologic stage is a unique and well-recognized prognostic indicator, however, more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment. Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial. Probably the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic therapy. The goal of this review is to critically evaluate the role of angiogenic markers, assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in anti-angiogenic therapie
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01T00:00:00Z
2011-01-01T00:00:00Z
2012-02-08T13:56:46Z
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instacron:RCAAP
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