Carbohydrate amphiphiles for supramolecular biomaterials: design, self-assembly, and applications

Detalhes bibliográficos
Autor(a) principal: Brito, Alexandra Manuela Fernandes
Data de Publicação: 2021
Outros Autores: Kassem, Salma, Reis, R. L., Ulijn, Rein V., Pires, R. A., Pashkuleva, I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/73000
Resumo: Carbohydrate-containing biopolymers such as glycoproteins, proteoglycans, and glycolipids are an incredibly diverse and complex set of natural building blocks used by biological systems to endorse a wide range of molecular functions that are critical to life processes. Simplified synthetic analogs of these polymeric glycoconjugates can capture some of these functions and are increasingly exploited toward the development of supramolecular biomaterials. These carbohydrate amphiphiles can mimic structural aspects through cooperative molecular self-assembly or target distinct signaling pathways through engineered (multivalent) interactions with biological systems. Herein, we discuss the supramolecular principles that regulate the glycome function(s) and the translation of these in the design of supramolecular biomaterials in which carbohydrates are used as information-rich structural elements with huge potential as therapeutic supramolecular biomaterials.
id RCAP_2f4c50a9f95761642521ca79f4657a3b
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/73000
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Carbohydrate amphiphiles for supramolecular biomaterials: design, self-assembly, and applicationsGlycoconjugateGlycolipidGlycopeptideHydrogelMultivalencySelf-assemblySystems chemistrySDG3: Good health and well-beingScience & TechnologyCarbohydrate-containing biopolymers such as glycoproteins, proteoglycans, and glycolipids are an incredibly diverse and complex set of natural building blocks used by biological systems to endorse a wide range of molecular functions that are critical to life processes. Simplified synthetic analogs of these polymeric glycoconjugates can capture some of these functions and are increasingly exploited toward the development of supramolecular biomaterials. These carbohydrate amphiphiles can mimic structural aspects through cooperative molecular self-assembly or target distinct signaling pathways through engineered (multivalent) interactions with biological systems. Herein, we discuss the supramolecular principles that regulate the glycome function(s) and the translation of these in the design of supramolecular biomaterials in which carbohydrates are used as information-rich structural elements with huge potential as therapeutic supramolecular biomaterials.We acknowledge the EU’s H2020 program (Forecast 668983) and the Portuguese FCT (BD/113794/2015; PTDC/NAN-MAT/28468/2017 CANCER_CAGE; PTDC/BTM-MAT/28327/2017 CardioHeal) for the financial support. A.B. is grateful to the Portuguese League Against Cancer for her fellowshipElsevierUniversidade do MinhoBrito, Alexandra Manuela FernandesKassem, SalmaReis, R. L.Ulijn, Rein V.Pires, R. A.Pashkuleva, I.2021-052021-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/73000engBrito A., Kassem S., Reis R. L., Ulijn R. V., Pires R. A., Pashkuleva I. Carbohydrate amphiphiles for supramolecular biomaterials: Design, self-assembly, and applications, Chem, Vol. 2021, doi:10.1016/j.chempr.2021.04.011, 20212451-929410.1016/j.chempr.2021.04.011https://www.sciencedirect.com/science/article/abs/pii/S2451929421002126#!info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-13T01:23:51Zoai:repositorium.sdum.uminho.pt:1822/73000Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:56:49.785684Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Carbohydrate amphiphiles for supramolecular biomaterials: design, self-assembly, and applications
title Carbohydrate amphiphiles for supramolecular biomaterials: design, self-assembly, and applications
spellingShingle Carbohydrate amphiphiles for supramolecular biomaterials: design, self-assembly, and applications
Brito, Alexandra Manuela Fernandes
Glycoconjugate
Glycolipid
Glycopeptide
Hydrogel
Multivalency
Self-assembly
Systems chemistry
SDG3: Good health and well-being
Science & Technology
title_short Carbohydrate amphiphiles for supramolecular biomaterials: design, self-assembly, and applications
title_full Carbohydrate amphiphiles for supramolecular biomaterials: design, self-assembly, and applications
title_fullStr Carbohydrate amphiphiles for supramolecular biomaterials: design, self-assembly, and applications
title_full_unstemmed Carbohydrate amphiphiles for supramolecular biomaterials: design, self-assembly, and applications
title_sort Carbohydrate amphiphiles for supramolecular biomaterials: design, self-assembly, and applications
author Brito, Alexandra Manuela Fernandes
author_facet Brito, Alexandra Manuela Fernandes
Kassem, Salma
Reis, R. L.
Ulijn, Rein V.
Pires, R. A.
Pashkuleva, I.
author_role author
author2 Kassem, Salma
Reis, R. L.
Ulijn, Rein V.
Pires, R. A.
Pashkuleva, I.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Brito, Alexandra Manuela Fernandes
Kassem, Salma
Reis, R. L.
Ulijn, Rein V.
Pires, R. A.
Pashkuleva, I.
dc.subject.por.fl_str_mv Glycoconjugate
Glycolipid
Glycopeptide
Hydrogel
Multivalency
Self-assembly
Systems chemistry
SDG3: Good health and well-being
Science & Technology
topic Glycoconjugate
Glycolipid
Glycopeptide
Hydrogel
Multivalency
Self-assembly
Systems chemistry
SDG3: Good health and well-being
Science & Technology
description Carbohydrate-containing biopolymers such as glycoproteins, proteoglycans, and glycolipids are an incredibly diverse and complex set of natural building blocks used by biological systems to endorse a wide range of molecular functions that are critical to life processes. Simplified synthetic analogs of these polymeric glycoconjugates can capture some of these functions and are increasingly exploited toward the development of supramolecular biomaterials. These carbohydrate amphiphiles can mimic structural aspects through cooperative molecular self-assembly or target distinct signaling pathways through engineered (multivalent) interactions with biological systems. Herein, we discuss the supramolecular principles that regulate the glycome function(s) and the translation of these in the design of supramolecular biomaterials in which carbohydrates are used as information-rich structural elements with huge potential as therapeutic supramolecular biomaterials.
publishDate 2021
dc.date.none.fl_str_mv 2021-05
2021-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/73000
url https://hdl.handle.net/1822/73000
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brito A., Kassem S., Reis R. L., Ulijn R. V., Pires R. A., Pashkuleva I. Carbohydrate amphiphiles for supramolecular biomaterials: Design, self-assembly, and applications, Chem, Vol. 2021, doi:10.1016/j.chempr.2021.04.011, 2021
2451-9294
10.1016/j.chempr.2021.04.011
https://www.sciencedirect.com/science/article/abs/pii/S2451929421002126#!
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132356505763840

Registros relacionados