Encapsulation of luminescent B(III), Pt(II) complexes and other emitters into functionalized polymeric micro and nanoparticles as potential biomedical imaging tools.
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/112893 |
Resumo: | In this present work, three different classes of fluorescent dyes were characterized, photophysically at the nano scale or at the macro scale, and were further explored to be used as sensors and emissive materials. All nanoscale studies were achieved synthesizing several polymeric micro and nanoparticles doped with two different classes of complexes, boron(III) and platinum(II) and using several polymer matrixes. The first dopant system was based on boron difluoride complexes, varying their alkyl side chain while the chosen polymer matrixes were poly(methyl methacrylate) (PMMA), polyvinylpyrrolidone (PVP) and polystyrene-block-polybutadiene-block-polystyrene (SBS co-polymer). The polymer matrixes, as well as the alkyl side chain, were found to influence the emission and the size of the particles. The particles were considered stable during all thermal stability studies at least during a month, with low variation in the emission intensity, showing promising results as temperature-dependent emission materials. Additionally, a comparison was stablished regarding the macro scale that was reported in a previous work. Co-doped particles were synthesized to develop a system to entrap highly hydrophobic drugs that showed interesting results to be explored in dye&drug-delivery. The second dopant system based on platinum(II) complexes was developed exploring the self-assembly and the aggregation-induced emission enhancement properties of a pyridylpyrazolate Pt(II) metallomesogenic system. The synthesis was achieved by formation of oil-in-water droplets similarly to the previous system. Finally, several coumarin-based pyrazolines compounds were characterized as an attempt to design novel stimuli-responsive chromic materials exhibiting non-reversible thermo-, mechano-, solvato- and vapochromic behaviors due to the presence of intermolecular ··· interactions. |
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Encapsulation of luminescent B(III), Pt(II) complexes and other emitters into functionalized polymeric micro and nanoparticles as potential biomedical imaging tools.SensorsNanoparticlesSelf-assemblyThermochromismMechanochromismVapochromismDomínio/Área Científica::Engenharia e Tecnologia::Engenharia QuímicaIn this present work, three different classes of fluorescent dyes were characterized, photophysically at the nano scale or at the macro scale, and were further explored to be used as sensors and emissive materials. All nanoscale studies were achieved synthesizing several polymeric micro and nanoparticles doped with two different classes of complexes, boron(III) and platinum(II) and using several polymer matrixes. The first dopant system was based on boron difluoride complexes, varying their alkyl side chain while the chosen polymer matrixes were poly(methyl methacrylate) (PMMA), polyvinylpyrrolidone (PVP) and polystyrene-block-polybutadiene-block-polystyrene (SBS co-polymer). The polymer matrixes, as well as the alkyl side chain, were found to influence the emission and the size of the particles. The particles were considered stable during all thermal stability studies at least during a month, with low variation in the emission intensity, showing promising results as temperature-dependent emission materials. Additionally, a comparison was stablished regarding the macro scale that was reported in a previous work. Co-doped particles were synthesized to develop a system to entrap highly hydrophobic drugs that showed interesting results to be explored in dye&drug-delivery. The second dopant system based on platinum(II) complexes was developed exploring the self-assembly and the aggregation-induced emission enhancement properties of a pyridylpyrazolate Pt(II) metallomesogenic system. The synthesis was achieved by formation of oil-in-water droplets similarly to the previous system. Finally, several coumarin-based pyrazolines compounds were characterized as an attempt to design novel stimuli-responsive chromic materials exhibiting non-reversible thermo-, mechano-, solvato- and vapochromic behaviors due to the presence of intermolecular ··· interactions.Lodeiro Y Espiño, CarlosCuerva Alaiz, CristianRUNDuarte, Frederico Gonçalo do Vale2021-09-30T00:30:41Z2021-02-2420202021-02-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/112893enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:56:12Zoai:run.unl.pt:10362/112893Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:42:14.384144Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Encapsulation of luminescent B(III), Pt(II) complexes and other emitters into functionalized polymeric micro and nanoparticles as potential biomedical imaging tools. |
title |
Encapsulation of luminescent B(III), Pt(II) complexes and other emitters into functionalized polymeric micro and nanoparticles as potential biomedical imaging tools. |
spellingShingle |
Encapsulation of luminescent B(III), Pt(II) complexes and other emitters into functionalized polymeric micro and nanoparticles as potential biomedical imaging tools. Duarte, Frederico Gonçalo do Vale Sensors Nanoparticles Self-assembly Thermochromism Mechanochromism Vapochromism Domínio/Área Científica::Engenharia e Tecnologia::Engenharia Química |
title_short |
Encapsulation of luminescent B(III), Pt(II) complexes and other emitters into functionalized polymeric micro and nanoparticles as potential biomedical imaging tools. |
title_full |
Encapsulation of luminescent B(III), Pt(II) complexes and other emitters into functionalized polymeric micro and nanoparticles as potential biomedical imaging tools. |
title_fullStr |
Encapsulation of luminescent B(III), Pt(II) complexes and other emitters into functionalized polymeric micro and nanoparticles as potential biomedical imaging tools. |
title_full_unstemmed |
Encapsulation of luminescent B(III), Pt(II) complexes and other emitters into functionalized polymeric micro and nanoparticles as potential biomedical imaging tools. |
title_sort |
Encapsulation of luminescent B(III), Pt(II) complexes and other emitters into functionalized polymeric micro and nanoparticles as potential biomedical imaging tools. |
author |
Duarte, Frederico Gonçalo do Vale |
author_facet |
Duarte, Frederico Gonçalo do Vale |
author_role |
author |
dc.contributor.none.fl_str_mv |
Lodeiro Y Espiño, Carlos Cuerva Alaiz, Cristian RUN |
dc.contributor.author.fl_str_mv |
Duarte, Frederico Gonçalo do Vale |
dc.subject.por.fl_str_mv |
Sensors Nanoparticles Self-assembly Thermochromism Mechanochromism Vapochromism Domínio/Área Científica::Engenharia e Tecnologia::Engenharia Química |
topic |
Sensors Nanoparticles Self-assembly Thermochromism Mechanochromism Vapochromism Domínio/Área Científica::Engenharia e Tecnologia::Engenharia Química |
description |
In this present work, three different classes of fluorescent dyes were characterized, photophysically at the nano scale or at the macro scale, and were further explored to be used as sensors and emissive materials. All nanoscale studies were achieved synthesizing several polymeric micro and nanoparticles doped with two different classes of complexes, boron(III) and platinum(II) and using several polymer matrixes. The first dopant system was based on boron difluoride complexes, varying their alkyl side chain while the chosen polymer matrixes were poly(methyl methacrylate) (PMMA), polyvinylpyrrolidone (PVP) and polystyrene-block-polybutadiene-block-polystyrene (SBS co-polymer). The polymer matrixes, as well as the alkyl side chain, were found to influence the emission and the size of the particles. The particles were considered stable during all thermal stability studies at least during a month, with low variation in the emission intensity, showing promising results as temperature-dependent emission materials. Additionally, a comparison was stablished regarding the macro scale that was reported in a previous work. Co-doped particles were synthesized to develop a system to entrap highly hydrophobic drugs that showed interesting results to be explored in dye&drug-delivery. The second dopant system based on platinum(II) complexes was developed exploring the self-assembly and the aggregation-induced emission enhancement properties of a pyridylpyrazolate Pt(II) metallomesogenic system. The synthesis was achieved by formation of oil-in-water droplets similarly to the previous system. Finally, several coumarin-based pyrazolines compounds were characterized as an attempt to design novel stimuli-responsive chromic materials exhibiting non-reversible thermo-, mechano-, solvato- and vapochromic behaviors due to the presence of intermolecular ··· interactions. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2021-09-30T00:30:41Z 2021-02-24 2021-02-24T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/112893 |
url |
http://hdl.handle.net/10362/112893 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799138034315165696 |