Biofilms in diabetic foot ulcers: impact, risk factors and control strategies
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/73813 |
Resumo: | Diabetic foot ulcers (DFUs) are a serious complication from diabetes mellitus, with a huge economic, social and psychological impact on the patients life. One of the main reasons why DFUs are so difficult to heal is related to the presence of biofilms. Biofilms promote wound inflammation and a remarkable lack of response to host defences/treatment options, which can lead to disease progression and chronicity. In fact, appropriate treatment for the elimination of these microbial communities can prevent the disease evolution and, in some cases, even avoid more serious outcomes, such as amputation or death. However, the detection of biofilm-associated DFUs is difficult due to the lack of methods for diagnostics in clinical settings. In this review, the current knowledge on the involvement of biofilms in DFUs is discussed, as well as how the surrounding environment influences biofilm formation and regulation, along with its clinical implications. A special focus is also given to biofilm-associated DFU diagnosis and therapeutic strategies. An overview on promising alternative therapeutics is provided and an algorithm considering biofilm detection and treatment is proposed. |
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Biofilms in diabetic foot ulcers: impact, risk factors and control strategiesBiofilmsChronic woundsCombination therapyMultidrug resistancePathophysiologyPolymicrobial aetiologyScience & TechnologyDiabetic foot ulcers (DFUs) are a serious complication from diabetes mellitus, with a huge economic, social and psychological impact on the patients life. One of the main reasons why DFUs are so difficult to heal is related to the presence of biofilms. Biofilms promote wound inflammation and a remarkable lack of response to host defences/treatment options, which can lead to disease progression and chronicity. In fact, appropriate treatment for the elimination of these microbial communities can prevent the disease evolution and, in some cases, even avoid more serious outcomes, such as amputation or death. However, the detection of biofilm-associated DFUs is difficult due to the lack of methods for diagnostics in clinical settings. In this review, the current knowledge on the involvement of biofilms in DFUs is discussed, as well as how the surrounding environment influences biofilm formation and regulation, along with its clinical implications. A special focus is also given to biofilm-associated DFU diagnosis and therapeutic strategies. An overview on promising alternative therapeutics is provided and an algorithm considering biofilm detection and treatment is proposed.This work was supported by: Base Funding—UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy—LEPABE—funded by national funds through the FCT/MCTES (PIDDAC); Project Biocide_for_Biofilm-PTDC/BII-BTI/30219/2017- POCI-01-0145-FEDER-030219, ABFISH–PTDC/ASP-PES/28397/2017-POCI-01-0145-FEDER- 028397 and Germirrad-POCI-01-0247-FEDER-072237, funded by FEDER funds through COMPETE2020— Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (PID DAC) through FCT/MCTES. The authors also thank the CITAB (Centre for the Research and Technol ogy of Agro-Environmental and Biological Sciences) under the scope of the FCT funds with reference UIDB/AGR/04033/2020. Ana Afonso (2020.04773.BD) and Diana Oliveira (SFRH/BD/138217/2018) acknowledge the FCT grants. Anabela Borges thanks the FCT for the financial support of their work contract through the Scientific Employment Stimulus—Individual Call—[CEECIND/01261/2017].info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoAfonso, Ana C.Oliveira, DianaSaavedra, Maria JoséBorges, AnabelaSimões, Manuel2021-072021-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/73813engAfonso, Ana C.; Oliveira, Diana; Saavedra, Maria José; Borges, Anabela; Simões, Manuel, Biofilms in diabetic foot ulcers: impact, risk factors and control strategies. International Journal of Molecular Sciences, 22(15), 8278, 20211424-67831422-006710.3390/ijms2215827834361044http://www.mdpi.com/journal/ijmsinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:12:09Zoai:repositorium.sdum.uminho.pt:1822/73813Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:04:03.681153Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Biofilms in diabetic foot ulcers: impact, risk factors and control strategies |
title |
Biofilms in diabetic foot ulcers: impact, risk factors and control strategies |
spellingShingle |
Biofilms in diabetic foot ulcers: impact, risk factors and control strategies Afonso, Ana C. Biofilms Chronic wounds Combination therapy Multidrug resistance Pathophysiology Polymicrobial aetiology Science & Technology |
title_short |
Biofilms in diabetic foot ulcers: impact, risk factors and control strategies |
title_full |
Biofilms in diabetic foot ulcers: impact, risk factors and control strategies |
title_fullStr |
Biofilms in diabetic foot ulcers: impact, risk factors and control strategies |
title_full_unstemmed |
Biofilms in diabetic foot ulcers: impact, risk factors and control strategies |
title_sort |
Biofilms in diabetic foot ulcers: impact, risk factors and control strategies |
author |
Afonso, Ana C. |
author_facet |
Afonso, Ana C. Oliveira, Diana Saavedra, Maria José Borges, Anabela Simões, Manuel |
author_role |
author |
author2 |
Oliveira, Diana Saavedra, Maria José Borges, Anabela Simões, Manuel |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Afonso, Ana C. Oliveira, Diana Saavedra, Maria José Borges, Anabela Simões, Manuel |
dc.subject.por.fl_str_mv |
Biofilms Chronic wounds Combination therapy Multidrug resistance Pathophysiology Polymicrobial aetiology Science & Technology |
topic |
Biofilms Chronic wounds Combination therapy Multidrug resistance Pathophysiology Polymicrobial aetiology Science & Technology |
description |
Diabetic foot ulcers (DFUs) are a serious complication from diabetes mellitus, with a huge economic, social and psychological impact on the patients life. One of the main reasons why DFUs are so difficult to heal is related to the presence of biofilms. Biofilms promote wound inflammation and a remarkable lack of response to host defences/treatment options, which can lead to disease progression and chronicity. In fact, appropriate treatment for the elimination of these microbial communities can prevent the disease evolution and, in some cases, even avoid more serious outcomes, such as amputation or death. However, the detection of biofilm-associated DFUs is difficult due to the lack of methods for diagnostics in clinical settings. In this review, the current knowledge on the involvement of biofilms in DFUs is discussed, as well as how the surrounding environment influences biofilm formation and regulation, along with its clinical implications. A special focus is also given to biofilm-associated DFU diagnosis and therapeutic strategies. An overview on promising alternative therapeutics is provided and an algorithm considering biofilm detection and treatment is proposed. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07 2021-07-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/73813 |
url |
http://hdl.handle.net/1822/73813 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Afonso, Ana C.; Oliveira, Diana; Saavedra, Maria José; Borges, Anabela; Simões, Manuel, Biofilms in diabetic foot ulcers: impact, risk factors and control strategies. International Journal of Molecular Sciences, 22(15), 8278, 2021 1424-6783 1422-0067 10.3390/ijms22158278 34361044 http://www.mdpi.com/journal/ijms |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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