Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Cities
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/8672 |
Resumo: | The Multi-City Multi-Country Collaborative Research Network group authorship includes G. Carrasco, B.-Y. Chen, A. Entezari, Y. Guo, Y.L. Guo, M. Hashizume, I.-H. Holobaca, C. Íñiguez, J.J.K. Jaakkola, H. Kim, W. Lee, S. Li, M. Maasikmets, F. Mayvaneh, *B. Nunes*, H. Orru, S. Osorio, M.S. Ragettli, N. Ryti, P.H.N. Saldiva, A. Schneider, J. Schwartz, S. Tong, and A. Zanobetti. |
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Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 CitiesMulti-Country Multi-CitySulfur DioxideSO2MortalityAir PollutionEnvironmental ExposureHumansEpidemiologyEnvironmental PollutantsDeterminantes da Saúde e da DoençaThe Multi-City Multi-Country Collaborative Research Network group authorship includes G. Carrasco, B.-Y. Chen, A. Entezari, Y. Guo, Y.L. Guo, M. Hashizume, I.-H. Holobaca, C. Íñiguez, J.J.K. Jaakkola, H. Kim, W. Lee, S. Li, M. Maasikmets, F. Mayvaneh, *B. Nunes*, H. Orru, S. Osorio, M.S. Ragettli, N. Ryti, P.H.N. Saldiva, A. Schneider, J. Schwartz, S. Tong, and A. Zanobetti.B. Nunes - Departamento de Epidemiologia do INSABackground: Epidemiological evidence on the health risks of sulfur dioxide (sulfur dioxide SO2) is more limited compared with other pollutants, and doubts remain on several aspects, such as the form of the exposure–response relationship, the potential role of copollutants, as well as the actual risk at low concentrations and possible temporal variation in risks. Objectives: Our aim was to assess the short-term association between exposure to sulfur dioxide SO2 and daily mortality in a large multilocation data set, using advanced study designs and statistical techniques. Methods: The analysis included 43,729,018 deaths that occurred in 399 cities within 23 countries between 1980 and 2018. A two-stage design was applied to assess the association between the daily concentration of sulfur dioxide SO2 and mortality counts, including first-stage time-series regressions and second-stage multilevel random-effect meta-analyses. Secondary analyses assessed the exposure–response shape and the lag structure using spline terms and distributed lag models, respectively, and temporal variations in risk using a longitudinal meta-regression. Bi-pollutant models were applied to examine confounding effects of particulate matter with an aerodynamic diameter of less than or equal to 10 micrometers≤10μm (particulate matter begin subscript 10 end subscriptPM10) and 2.5 micrometers2.5μm (particulate matter begin subscript 2.5 end subscriptPM2.5), ozone, nitrogen dioxide, and carbon monoxide. Associations were reported as relative risks (RRs) and fractions of excess deaths. Results: The average daily concentration of sulfur dioxideSO2 across the 399 cities was 11.7 micrograms per meter cubed11.7 μg/m3, with 4.7% of days above the World Health Organization (WHO) guideline limit (40 micrograms per meter cubed40 μg/m3, 24-h average), although the exceedances occurred predominantly in specific locations. Exposure levels decreased considerably during the study period, from an average concentration of 19.0 micrograms per meter cubed19.0 μg/m3 in 1980–1989 to 6.3 micrograms per meter cubed6.3 μg/m3 in 2010–2018. For all locations combined, a 10 microgram per meter cubed10-μg/m3 increase in daily sulfur dioxide SO2 was associated with an RR of mortality of 1.0045 [95% confidence interval (CI): 1.0019, 1.0070], with the risk being stable over time but with substantial between-country heterogeneity. Short-term exposure to sulfur dioxide SO2 was associated with an excess mortality fraction of 0.50% [95% empirical CI (eCI): 0.42%, 0.57%] in the 399 cities, although decreasing from 0.74% (0.61%, 0.85%) in 1980–1989 to 0.37% (0.27%, 0.47%) in 2010–2018. There was some evidence of nonlinearity, with a steep exposure–response relationship at low concentrations and the risk attenuating at higher levels. The relevant lag window was 0–3 d. Significant positive associations remained after controlling for other pollutants. Discussion: The analysis revealed independent mortality risks associated with short-term exposure to sulfur dioxideSO2, with no evidence of a threshold. Levels below the current WHO guidelines for 24-h averages were still associated with substantial excess mortality, indicating the potential benefits of stricter air quality standards.This study was supported by the Medical Research Council UK[MR/R013349/1 (to A.G.)] and the European Union’s Horizon 2020Project Exhaustion [820655 (to A.G.)]. Additional grants supportedindividual researchers: H.K. was supported by the National NaturalScience Foundation of China (92043301), J.M. was supported by afellowship of Fundação para a Ciência e a Tecnlogia (SFRH/BPD/115112/2016), and A.T. was supported by Ministerio de Ciencia eInnovacion/Agencia Estatal de Investigación (MCIN/AEI/10.13039/501100011033; CEX2018-000794-S).The Multi-City Multi-Country Collaborative Research Networkgroup authorship includes G. Carrasco, B.-Y. Chen, A. Entezari,Y. Guo, Y.L. Guo, M. Hashizume, I.-H. Holobaca, C. Íñiguez,J.J.K. Jaakkola, H. Kim, W. Lee, S. Li, M. Maasikmets,F. Mayvaneh, B. Nunes, H. Orru, S. Osorio, M.S. Ragettli, N. Ryti,P.H.N. Saldiva, A. Schneider, J. Schwartz, S. Tong, and A. ZanobettiNational Institute of Environmental Health SciencesRepositório Científico do Instituto Nacional de SaúdeO’Brien, EdwardMasselot, PierreSera, FrancescoRoye, DominicBreitner, SusanneNg, Chris Fook Shengde Sousa Zanotti Stagliorio Coelho, MichelineMadureira, JoanaTobias, AurelioVicedo-Cabrera, Ana MariaBell, Michelle L.Lavigne, EricKan, HaidongGasparrini, AntonioMCC Collaborative Research Network2023-10-09T11:11:10Z2023-03-082023-03-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8672engEnviron Health Perspect. 2023 Mar;131(3):37002. doi: 10.1289/EHP11112. Epub 2023 Mar 8.0091-676510.1289/EHP11112info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-14T01:31:50Zoai:repositorio.insa.pt:10400.18/8672Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:35:33.593344Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Cities |
| title |
Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Cities |
| spellingShingle |
Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Cities O’Brien, Edward Multi-Country Multi-City Sulfur Dioxide SO2 Mortality Air Pollution Environmental Exposure Humans Epidemiology Environmental Pollutants Determinantes da Saúde e da Doença |
| title_short |
Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Cities |
| title_full |
Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Cities |
| title_fullStr |
Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Cities |
| title_full_unstemmed |
Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Cities |
| title_sort |
Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Cities |
| author |
O’Brien, Edward |
| author_facet |
O’Brien, Edward Masselot, Pierre Sera, Francesco Roye, Dominic Breitner, Susanne Ng, Chris Fook Sheng de Sousa Zanotti Stagliorio Coelho, Micheline Madureira, Joana Tobias, Aurelio Vicedo-Cabrera, Ana Maria Bell, Michelle L. Lavigne, Eric Kan, Haidong Gasparrini, Antonio MCC Collaborative Research Network |
| author_role |
author |
| author2 |
Masselot, Pierre Sera, Francesco Roye, Dominic Breitner, Susanne Ng, Chris Fook Sheng de Sousa Zanotti Stagliorio Coelho, Micheline Madureira, Joana Tobias, Aurelio Vicedo-Cabrera, Ana Maria Bell, Michelle L. Lavigne, Eric Kan, Haidong Gasparrini, Antonio MCC Collaborative Research Network |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
O’Brien, Edward Masselot, Pierre Sera, Francesco Roye, Dominic Breitner, Susanne Ng, Chris Fook Sheng de Sousa Zanotti Stagliorio Coelho, Micheline Madureira, Joana Tobias, Aurelio Vicedo-Cabrera, Ana Maria Bell, Michelle L. Lavigne, Eric Kan, Haidong Gasparrini, Antonio MCC Collaborative Research Network |
| dc.subject.por.fl_str_mv |
Multi-Country Multi-City Sulfur Dioxide SO2 Mortality Air Pollution Environmental Exposure Humans Epidemiology Environmental Pollutants Determinantes da Saúde e da Doença |
| topic |
Multi-Country Multi-City Sulfur Dioxide SO2 Mortality Air Pollution Environmental Exposure Humans Epidemiology Environmental Pollutants Determinantes da Saúde e da Doença |
| description |
The Multi-City Multi-Country Collaborative Research Network group authorship includes G. Carrasco, B.-Y. Chen, A. Entezari, Y. Guo, Y.L. Guo, M. Hashizume, I.-H. Holobaca, C. Íñiguez, J.J.K. Jaakkola, H. Kim, W. Lee, S. Li, M. Maasikmets, F. Mayvaneh, *B. Nunes*, H. Orru, S. Osorio, M.S. Ragettli, N. Ryti, P.H.N. Saldiva, A. Schneider, J. Schwartz, S. Tong, and A. Zanobetti. |
| publishDate |
2023 |
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2023-10-09T11:11:10Z 2023-03-08 2023-03-08T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.18/8672 |
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http://hdl.handle.net/10400.18/8672 |
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eng |
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eng |
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Environ Health Perspect. 2023 Mar;131(3):37002. doi: 10.1289/EHP11112. Epub 2023 Mar 8. 0091-6765 10.1289/EHP11112 |
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openAccess |
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application/pdf |
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National Institute of Environmental Health Sciences |
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National Institute of Environmental Health Sciences |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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