Nanotechnology solutions for controlled cytokine delivery: an applied perspective
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/68085 |
Resumo: | Around 200 cytokines with roles in cell signaling have been identified and studied, with the vast majority belonging to the four-α-helix bundle family. These proteins exert their function by binding to specific receptors and are implicated in many diseases. The use of several cytokines as therapeutic targets has been approved by the FDA, however their rapid clearance in vivo still greatly limits their efficacy. Nano-based drug delivery systems have been widely applied in nanomedicine to develop safe, specific and controlled delivery techniques. Nevertheless, each nanomaterial has its own specifications and their suitability towards the biochemical and biophysical properties of the selected drug needs to be determined, weighing in the final choice of the ideal nano drug delivery system. Nanoparticles remain the most used vehicle for cytokine delivery, where polymeric carriers represent the vast majority of the studied systems. Liposomes and gold or silica nanoparticles are also explored and discussed in this review. Additionally, surface functionalization is of great importance to facilitate the attachment of a wide variety of molecules and modify features such as bioavailability. Since the monitoring of cytokine levels has an important role in early clinical diagnosis and for assessing therapeutic efficacy, nanotechnological advances are also valuable for nanosensor development. |
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Nanotechnology solutions for controlled cytokine delivery: an applied perspectiveCytokineIL-6 cytokine familyNanoparticlesNanotechnologyCiências Naturais::Ciências BiológicasScience & TechnologyAround 200 cytokines with roles in cell signaling have been identified and studied, with the vast majority belonging to the four-α-helix bundle family. These proteins exert their function by binding to specific receptors and are implicated in many diseases. The use of several cytokines as therapeutic targets has been approved by the FDA, however their rapid clearance in vivo still greatly limits their efficacy. Nano-based drug delivery systems have been widely applied in nanomedicine to develop safe, specific and controlled delivery techniques. Nevertheless, each nanomaterial has its own specifications and their suitability towards the biochemical and biophysical properties of the selected drug needs to be determined, weighing in the final choice of the ideal nano drug delivery system. Nanoparticles remain the most used vehicle for cytokine delivery, where polymeric carriers represent the vast majority of the studied systems. Liposomes and gold or silica nanoparticles are also explored and discussed in this review. Additionally, surface functionalization is of great importance to facilitate the attachment of a wide variety of molecules and modify features such as bioavailability. Since the monitoring of cytokine levels has an important role in early clinical diagnosis and for assessing therapeutic efficacy, nanotechnological advances are also valuable for nanosensor development.This work was supported by the “Contrato-Programa” UIDB/04050/2020 funded by national funds through the FCT I.P. and project FUN2CYT: Harnessing the potential for biomedical applications of pleiotropic cytokines LIF and oncostatin M (POCI-01-0145-FEDER-030568) supported by Programa Operacional Competitividade e Internacionalização (FEDER) and FCT, IP. Anabela Gonçalves acknowledges her PhD scholarship from FCT (SFRH/BD/146807/2019).Multidisciplinary Digital Publishing InstituteUniversidade do MinhoGonçalves, AnabelaMachado, RaulGomes, Andreia CCosta, André20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/68085engGonçalves, A.; Machado, R.; Gomes, A.C.; Costa, A. Nanotechnology Solutions for Controlled Cytokine Delivery: An Applied Perspective. Appl. Sci. 2020, 10, 7098. DOI: 10.3390/app102070982076-341710.3390/app10207098https://www.mdpi.com/2076-3417/10/20/7098info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:01:12Zoai:repositorium.sdum.uminho.pt:1822/68085Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:51:07.166622Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Nanotechnology solutions for controlled cytokine delivery: an applied perspective |
title |
Nanotechnology solutions for controlled cytokine delivery: an applied perspective |
spellingShingle |
Nanotechnology solutions for controlled cytokine delivery: an applied perspective Gonçalves, Anabela Cytokine IL-6 cytokine family Nanoparticles Nanotechnology Ciências Naturais::Ciências Biológicas Science & Technology |
title_short |
Nanotechnology solutions for controlled cytokine delivery: an applied perspective |
title_full |
Nanotechnology solutions for controlled cytokine delivery: an applied perspective |
title_fullStr |
Nanotechnology solutions for controlled cytokine delivery: an applied perspective |
title_full_unstemmed |
Nanotechnology solutions for controlled cytokine delivery: an applied perspective |
title_sort |
Nanotechnology solutions for controlled cytokine delivery: an applied perspective |
author |
Gonçalves, Anabela |
author_facet |
Gonçalves, Anabela Machado, Raul Gomes, Andreia C Costa, André |
author_role |
author |
author2 |
Machado, Raul Gomes, Andreia C Costa, André |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Gonçalves, Anabela Machado, Raul Gomes, Andreia C Costa, André |
dc.subject.por.fl_str_mv |
Cytokine IL-6 cytokine family Nanoparticles Nanotechnology Ciências Naturais::Ciências Biológicas Science & Technology |
topic |
Cytokine IL-6 cytokine family Nanoparticles Nanotechnology Ciências Naturais::Ciências Biológicas Science & Technology |
description |
Around 200 cytokines with roles in cell signaling have been identified and studied, with the vast majority belonging to the four-α-helix bundle family. These proteins exert their function by binding to specific receptors and are implicated in many diseases. The use of several cytokines as therapeutic targets has been approved by the FDA, however their rapid clearance in vivo still greatly limits their efficacy. Nano-based drug delivery systems have been widely applied in nanomedicine to develop safe, specific and controlled delivery techniques. Nevertheless, each nanomaterial has its own specifications and their suitability towards the biochemical and biophysical properties of the selected drug needs to be determined, weighing in the final choice of the ideal nano drug delivery system. Nanoparticles remain the most used vehicle for cytokine delivery, where polymeric carriers represent the vast majority of the studied systems. Liposomes and gold or silica nanoparticles are also explored and discussed in this review. Additionally, surface functionalization is of great importance to facilitate the attachment of a wide variety of molecules and modify features such as bioavailability. Since the monitoring of cytokine levels has an important role in early clinical diagnosis and for assessing therapeutic efficacy, nanotechnological advances are also valuable for nanosensor development. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/68085 |
url |
http://hdl.handle.net/1822/68085 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Gonçalves, A.; Machado, R.; Gomes, A.C.; Costa, A. Nanotechnology Solutions for Controlled Cytokine Delivery: An Applied Perspective. Appl. Sci. 2020, 10, 7098. DOI: 10.3390/app10207098 2076-3417 10.3390/app10207098 https://www.mdpi.com/2076-3417/10/20/7098 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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