Characterization of initial stages of diabetic macular edema
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/22744 |
Resumo: | This study is aimed at characterizing the type of retinal edema in the initial stages of retinopathy in type 2 diabetes. In this retrospective cross-sectional study, spectral domain optical coherence tomography (OCT) layer by layer analysis of the retina in association with OCT-Leakage, an algorithm to detect sites of low optical reflectivity, were used to examine eyes with minimal, mild, and moderate diabetic retinopathy (DR). A total of 142 eyes from 142 patients (28% women) aged 52–88 years were imaged. Macular edema, either subclinical (SCME) or central-involved macular edema (CIME), was present in 43% of eyes in group 10–20, 41% of eyes in group 35, and 38% of eyes in group 43–47. The inner nuclear layer (INL) was the layer showing higher and most frequent increases in retinal thickness (79%). The edema was predominantly intracellular in group 10–20 (65%) and extracellular in groups 35 (77%) and 43–47 (69%). Eyes from diabetic patients in the initial stages of DR with different Early Treatment Diabetic Retinopathy Study gradings show similar prevalence of SCME and CIME, independent of the severity of the retinopathy. Retinal edema is located mainly in the INL and appears to be mostly extracellular except in the earliest stages of diabetic retinal disease where intracellular edema predominates. |
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Characterization of initial stages of diabetic macular edemaDiabetic retinopathyMacular edemaOptical coherence tomographyOptical coherence tomography-leakageThis study is aimed at characterizing the type of retinal edema in the initial stages of retinopathy in type 2 diabetes. In this retrospective cross-sectional study, spectral domain optical coherence tomography (OCT) layer by layer analysis of the retina in association with OCT-Leakage, an algorithm to detect sites of low optical reflectivity, were used to examine eyes with minimal, mild, and moderate diabetic retinopathy (DR). A total of 142 eyes from 142 patients (28% women) aged 52–88 years were imaged. Macular edema, either subclinical (SCME) or central-involved macular edema (CIME), was present in 43% of eyes in group 10–20, 41% of eyes in group 35, and 38% of eyes in group 43–47. The inner nuclear layer (INL) was the layer showing higher and most frequent increases in retinal thickness (79%). The edema was predominantly intracellular in group 10–20 (65%) and extracellular in groups 35 (77%) and 43–47 (69%). Eyes from diabetic patients in the initial stages of DR with different Early Treatment Diabetic Retinopathy Study gradings show similar prevalence of SCME and CIME, independent of the severity of the retinopathy. Retinal edema is located mainly in the INL and appears to be mostly extracellular except in the earliest stages of diabetic retinal disease where intracellular edema predominates.KargerRepositório Científico do Instituto Politécnico do PortoSantos, Ana RitaSantos, TorcatoAlves, DalilaMarques, Inês P.Lobo, ConceiçãoCunha-Vaz, José2023-04-18T17:07:24Z2019-112019-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/22744engSantos, A. R., Santos, T., Alves, D., Marques, I. P., Lobo, C., & Cunha-Vaz, J. (2019). Characterization of Initial Stages of Diabetic Macular Edema. Ophthalmic Research, 62(4), 203–210. https://doi.org/10.1159/0004991170030-374710.1159/0004991171423-0259info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-26T01:45:35ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Characterization of initial stages of diabetic macular edema |
title |
Characterization of initial stages of diabetic macular edema |
spellingShingle |
Characterization of initial stages of diabetic macular edema Santos, Ana Rita Diabetic retinopathy Macular edema Optical coherence tomography Optical coherence tomography-leakage |
title_short |
Characterization of initial stages of diabetic macular edema |
title_full |
Characterization of initial stages of diabetic macular edema |
title_fullStr |
Characterization of initial stages of diabetic macular edema |
title_full_unstemmed |
Characterization of initial stages of diabetic macular edema |
title_sort |
Characterization of initial stages of diabetic macular edema |
author |
Santos, Ana Rita |
author_facet |
Santos, Ana Rita Santos, Torcato Alves, Dalila Marques, Inês P. Lobo, Conceição Cunha-Vaz, José |
author_role |
author |
author2 |
Santos, Torcato Alves, Dalila Marques, Inês P. Lobo, Conceição Cunha-Vaz, José |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Santos, Ana Rita Santos, Torcato Alves, Dalila Marques, Inês P. Lobo, Conceição Cunha-Vaz, José |
dc.subject.por.fl_str_mv |
Diabetic retinopathy Macular edema Optical coherence tomography Optical coherence tomography-leakage |
topic |
Diabetic retinopathy Macular edema Optical coherence tomography Optical coherence tomography-leakage |
description |
This study is aimed at characterizing the type of retinal edema in the initial stages of retinopathy in type 2 diabetes. In this retrospective cross-sectional study, spectral domain optical coherence tomography (OCT) layer by layer analysis of the retina in association with OCT-Leakage, an algorithm to detect sites of low optical reflectivity, were used to examine eyes with minimal, mild, and moderate diabetic retinopathy (DR). A total of 142 eyes from 142 patients (28% women) aged 52–88 years were imaged. Macular edema, either subclinical (SCME) or central-involved macular edema (CIME), was present in 43% of eyes in group 10–20, 41% of eyes in group 35, and 38% of eyes in group 43–47. The inner nuclear layer (INL) was the layer showing higher and most frequent increases in retinal thickness (79%). The edema was predominantly intracellular in group 10–20 (65%) and extracellular in groups 35 (77%) and 43–47 (69%). Eyes from diabetic patients in the initial stages of DR with different Early Treatment Diabetic Retinopathy Study gradings show similar prevalence of SCME and CIME, independent of the severity of the retinopathy. Retinal edema is located mainly in the INL and appears to be mostly extracellular except in the earliest stages of diabetic retinal disease where intracellular edema predominates. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11 2019-11-01T00:00:00Z 2023-04-18T17:07:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/22744 |
url |
http://hdl.handle.net/10400.22/22744 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Santos, A. R., Santos, T., Alves, D., Marques, I. P., Lobo, C., & Cunha-Vaz, J. (2019). Characterization of Initial Stages of Diabetic Macular Edema. Ophthalmic Research, 62(4), 203–210. https://doi.org/10.1159/000499117 0030-3747 10.1159/000499117 1423-0259 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Karger |
publisher.none.fl_str_mv |
Karger |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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repository.mail.fl_str_mv |
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_version_ |
1777302446727495680 |