Outcomes of culture-negative vs. culture-positive infective endocarditis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/143629 |
Resumo: | Funding: The study has received funding from Abbott Vascular Int. (2011–2021), Amgen Cardiovascular (2009–2018), AstraZeneca (2014–2021), Bayer AG (2009–2018), Boehringer Ingelheim (2009–2019), Boston Scientific (2009–2012), The Bristol Myers Squibb and Pfizer Alliance (2011– 2019), Daiichi Sankyo Europe GmbH (2011–2020), The Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and Company (2014–2017), Edwards (2016–2019), Gedeon Richter Plc. (2014–2016), Menarini Int. Op. (2009–2012), MSD-Merck & Co. (2011–2014), Novartis Pharma AG (2014–2020), ResMed (2014–2016), Sanofi (2009–2011), SERVIER (2009–2021), and Vifor (2019–2022) |
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Outcomes of culture-negative vs. culture-positive infective endocarditisthe ESC-EORP EURO-ENDO registryBlood culture-negative endocarditisDiagnosisEndocarditisHeart valvesInfective endocarditisSurgeryCardiology and Cardiovascular MedicineFunding: The study has received funding from Abbott Vascular Int. (2011–2021), Amgen Cardiovascular (2009–2018), AstraZeneca (2014–2021), Bayer AG (2009–2018), Boehringer Ingelheim (2009–2019), Boston Scientific (2009–2012), The Bristol Myers Squibb and Pfizer Alliance (2011– 2019), Daiichi Sankyo Europe GmbH (2011–2020), The Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and Company (2014–2017), Edwards (2016–2019), Gedeon Richter Plc. (2014–2016), Menarini Int. Op. (2009–2012), MSD-Merck & Co. (2011–2014), Novartis Pharma AG (2014–2020), ResMed (2014–2016), Sanofi (2009–2011), SERVIER (2009–2021), and Vifor (2019–2022)AIM: Fatality of infective endocarditis (IE) is high worldwide, and its diagnosis remains a challenge. The objective of the present study was to compare the clinical characteristics and outcomes of patients with culture-positive (CPIE) vs. culture-negative IE (CNIE). METHODS AND RESULTS: This was an ancillary analysis of the ESC-EORP EURO-ENDO registry. Overall, 3113 patients who were diagnosed with IE during the study period were included in the present study. Of these, 2590 (83.2%) had CPIE, whereas 523 (16.8%) had CNIE. As many as 1488 (48.1%) patients underwent cardiac surgery during the index hospitalization, 1259 (48.8%) with CPIE and 229 (44.5%) with CNIE. The CNIE was a predictor of 1-year mortality [hazard ratio (HR) 1.28, 95% confidence interval (CI) 1.04-1.56], whereas surgery was significantly associated with survival (HR 0.49, 95% CI 0.41-0.58). The 1-year mortality was significantly higher in CNIE than CPIE patients in the medical subgroup, but it was not significantly different in CNIE vs. CPIE patients who underwent surgery. CONCLUSION: The present analysis of the EURO-ENDO registry confirms a higher long-term mortality in patients with CNIE compared with patients with CPIE. This difference was present in patients receiving medical therapy alone and not in those who underwent surgery, with surgery being associated with reduced mortality. Additional efforts are required both to improve the aetiological diagnosis of IE and identify CNIE cases early before progressive disease potentially contraindicates surgery.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNKong, William K.F.Salsano, AntonioGiacobbe, Daniele RobertoPopescu, Bogdan A.Laroche, CécileDuval, XavierSchueler, RobertMoreo, AntonellaColonna, PaoloPiper, CorneliaCalvo-Iglesias, FranciscoBadano, Luigi P.Srdanovic, IlijaBoutoille, DavidHuttin, OlivierStöhr, ElisabethTimóteo, Ana TeresaVaskelyte, Jolanta JustinaSadeghpour, AnitaTornos, PilarAbid, LeilaPoh, Kian KeongHabib, GilbertLancellotti, Patrizio2022-09-09T22:40:47Z2022-08-012022-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/143629eng0195-668XPURE: 46123869https://doi.org/10.1093/eurheartj/ehac307info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:05:00Zoai:run.unl.pt:10362/143629Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:05Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Outcomes of culture-negative vs. culture-positive infective endocarditis the ESC-EORP EURO-ENDO registry |
| title |
Outcomes of culture-negative vs. culture-positive infective endocarditis |
| spellingShingle |
Outcomes of culture-negative vs. culture-positive infective endocarditis Kong, William K.F. Blood culture-negative endocarditis Diagnosis Endocarditis Heart valves Infective endocarditis Surgery Cardiology and Cardiovascular Medicine |
| title_short |
Outcomes of culture-negative vs. culture-positive infective endocarditis |
| title_full |
Outcomes of culture-negative vs. culture-positive infective endocarditis |
| title_fullStr |
Outcomes of culture-negative vs. culture-positive infective endocarditis |
| title_full_unstemmed |
Outcomes of culture-negative vs. culture-positive infective endocarditis |
| title_sort |
Outcomes of culture-negative vs. culture-positive infective endocarditis |
| author |
Kong, William K.F. |
| author_facet |
Kong, William K.F. Salsano, Antonio Giacobbe, Daniele Roberto Popescu, Bogdan A. Laroche, Cécile Duval, Xavier Schueler, Robert Moreo, Antonella Colonna, Paolo Piper, Cornelia Calvo-Iglesias, Francisco Badano, Luigi P. Srdanovic, Ilija Boutoille, David Huttin, Olivier Stöhr, Elisabeth Timóteo, Ana Teresa Vaskelyte, Jolanta Justina Sadeghpour, Anita Tornos, Pilar Abid, Leila Poh, Kian Keong Habib, Gilbert Lancellotti, Patrizio |
| author_role |
author |
| author2 |
Salsano, Antonio Giacobbe, Daniele Roberto Popescu, Bogdan A. Laroche, Cécile Duval, Xavier Schueler, Robert Moreo, Antonella Colonna, Paolo Piper, Cornelia Calvo-Iglesias, Francisco Badano, Luigi P. Srdanovic, Ilija Boutoille, David Huttin, Olivier Stöhr, Elisabeth Timóteo, Ana Teresa Vaskelyte, Jolanta Justina Sadeghpour, Anita Tornos, Pilar Abid, Leila Poh, Kian Keong Habib, Gilbert Lancellotti, Patrizio |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Kong, William K.F. Salsano, Antonio Giacobbe, Daniele Roberto Popescu, Bogdan A. Laroche, Cécile Duval, Xavier Schueler, Robert Moreo, Antonella Colonna, Paolo Piper, Cornelia Calvo-Iglesias, Francisco Badano, Luigi P. Srdanovic, Ilija Boutoille, David Huttin, Olivier Stöhr, Elisabeth Timóteo, Ana Teresa Vaskelyte, Jolanta Justina Sadeghpour, Anita Tornos, Pilar Abid, Leila Poh, Kian Keong Habib, Gilbert Lancellotti, Patrizio |
| dc.subject.por.fl_str_mv |
Blood culture-negative endocarditis Diagnosis Endocarditis Heart valves Infective endocarditis Surgery Cardiology and Cardiovascular Medicine |
| topic |
Blood culture-negative endocarditis Diagnosis Endocarditis Heart valves Infective endocarditis Surgery Cardiology and Cardiovascular Medicine |
| description |
Funding: The study has received funding from Abbott Vascular Int. (2011–2021), Amgen Cardiovascular (2009–2018), AstraZeneca (2014–2021), Bayer AG (2009–2018), Boehringer Ingelheim (2009–2019), Boston Scientific (2009–2012), The Bristol Myers Squibb and Pfizer Alliance (2011– 2019), Daiichi Sankyo Europe GmbH (2011–2020), The Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and Company (2014–2017), Edwards (2016–2019), Gedeon Richter Plc. (2014–2016), Menarini Int. Op. (2009–2012), MSD-Merck & Co. (2011–2014), Novartis Pharma AG (2014–2020), ResMed (2014–2016), Sanofi (2009–2011), SERVIER (2009–2021), and Vifor (2019–2022) |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-09-09T22:40:47Z 2022-08-01 2022-08-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/143629 |
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http://hdl.handle.net/10362/143629 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0195-668X PURE: 46123869 https://doi.org/10.1093/eurheartj/ehac307 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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11 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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