Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/156282 |
Resumo: | Background: Persistent inflammation related to aging (inflammaging) is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty.Methods: We analyzed available demographic, social, and clinical data in Spanish and Portuguese older adults [N = 601; age: mean (SD) 77.3 (8.0); 61% women]. Plasma T. gondii immunoglobulin G (IgG) serointensity was measured with an enzyme-linked immunosorbent assay. The Fried criteria were used to define frailty status. Validated translations of Mini-Mental State Examination, Geriatric Depression Scale, and the Charlson Comorbidity Index were used to evaluate confounders. Previously analyzed biomarkers that were significantly associated with frailty in both prior reports and the current study, and also related to T. gondii serointensity, were further accounted for in multivariable logistic models with frailty as outcome.Results: In T. gondii-seropositives, there was a significant positive association between T. gondii IgG serointensity and frailty, accounting for age (p = .0002), and resisting adjustment for multiple successive confounders. Among biomarkers linked with frailty, kynurenine/tryptophan and soluble tumor necrosis factor receptor II were positively associated with T. gondii serointensity in seropositives (p < .05). Associations with other biomarkers were not significant.Conclusions: This first reported association between T. gondii and frailty is limited by a cross-sectional design and warrants replication. While certain biomarkers of inflammaging were associated with both T. gondii IgG serointensity and frailty, they did not fully mediate the T. gondii-frailty association. |
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Toxoplasma gondii IgG Serointensity Is Positively Associated With FrailtyBackground: Persistent inflammation related to aging (inflammaging) is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty.Methods: We analyzed available demographic, social, and clinical data in Spanish and Portuguese older adults [N = 601; age: mean (SD) 77.3 (8.0); 61% women]. Plasma T. gondii immunoglobulin G (IgG) serointensity was measured with an enzyme-linked immunosorbent assay. The Fried criteria were used to define frailty status. Validated translations of Mini-Mental State Examination, Geriatric Depression Scale, and the Charlson Comorbidity Index were used to evaluate confounders. Previously analyzed biomarkers that were significantly associated with frailty in both prior reports and the current study, and also related to T. gondii serointensity, were further accounted for in multivariable logistic models with frailty as outcome.Results: In T. gondii-seropositives, there was a significant positive association between T. gondii IgG serointensity and frailty, accounting for age (p = .0002), and resisting adjustment for multiple successive confounders. Among biomarkers linked with frailty, kynurenine/tryptophan and soluble tumor necrosis factor receptor II were positively associated with T. gondii serointensity in seropositives (p < .05). Associations with other biomarkers were not significant.Conclusions: This first reported association between T. gondii and frailty is limited by a cross-sectional design and warrants replication. While certain biomarkers of inflammaging were associated with both T. gondii IgG serointensity and frailty, they did not fully mediate the T. gondii-frailty association.Oxford University Press20232024-01-01T00:00:00Z2024info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/156282eng1758-535X1079-500610.1093/gerona/glad228Mohyuddin, HLaffon, BTeixeira, JPCosta, STeixeira-Gomes, APásaro, EConstantine, NDagdag, AOrtmeyer, HKTizenberg, BAfram, LYen, PYMarano, CLowry, CAHoisington, AJRachbeisel, JAValdiglesias, VLema-Arranz, CFernández-Bertólez, NMaseda, AMillán-Calenti, JCKovacs, EJGostner, JMFuchs, DBrenner, LALorenzo-López, LPostolache, TTinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-08T01:19:04Zoai:repositorio-aberto.up.pt:10216/156282Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:35:58.994974Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty |
title |
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty |
spellingShingle |
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty Mohyuddin, H |
title_short |
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty |
title_full |
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty |
title_fullStr |
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty |
title_full_unstemmed |
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty |
title_sort |
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty |
author |
Mohyuddin, H |
author_facet |
Mohyuddin, H Laffon, B Teixeira, JP Costa, S Teixeira-Gomes, A Pásaro, E Constantine, N Dagdag, A Ortmeyer, HK Tizenberg, B Afram, L Yen, PY Marano, C Lowry, CA Hoisington, AJ Rachbeisel, JA Valdiglesias, V Lema-Arranz, C Fernández-Bertólez, N Maseda, A Millán-Calenti, JC Kovacs, EJ Gostner, JM Fuchs, D Brenner, LA Lorenzo-López, L Postolache, TT |
author_role |
author |
author2 |
Laffon, B Teixeira, JP Costa, S Teixeira-Gomes, A Pásaro, E Constantine, N Dagdag, A Ortmeyer, HK Tizenberg, B Afram, L Yen, PY Marano, C Lowry, CA Hoisington, AJ Rachbeisel, JA Valdiglesias, V Lema-Arranz, C Fernández-Bertólez, N Maseda, A Millán-Calenti, JC Kovacs, EJ Gostner, JM Fuchs, D Brenner, LA Lorenzo-López, L Postolache, TT |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mohyuddin, H Laffon, B Teixeira, JP Costa, S Teixeira-Gomes, A Pásaro, E Constantine, N Dagdag, A Ortmeyer, HK Tizenberg, B Afram, L Yen, PY Marano, C Lowry, CA Hoisington, AJ Rachbeisel, JA Valdiglesias, V Lema-Arranz, C Fernández-Bertólez, N Maseda, A Millán-Calenti, JC Kovacs, EJ Gostner, JM Fuchs, D Brenner, LA Lorenzo-López, L Postolache, TT |
description |
Background: Persistent inflammation related to aging (inflammaging) is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty.Methods: We analyzed available demographic, social, and clinical data in Spanish and Portuguese older adults [N = 601; age: mean (SD) 77.3 (8.0); 61% women]. Plasma T. gondii immunoglobulin G (IgG) serointensity was measured with an enzyme-linked immunosorbent assay. The Fried criteria were used to define frailty status. Validated translations of Mini-Mental State Examination, Geriatric Depression Scale, and the Charlson Comorbidity Index were used to evaluate confounders. Previously analyzed biomarkers that were significantly associated with frailty in both prior reports and the current study, and also related to T. gondii serointensity, were further accounted for in multivariable logistic models with frailty as outcome.Results: In T. gondii-seropositives, there was a significant positive association between T. gondii IgG serointensity and frailty, accounting for age (p = .0002), and resisting adjustment for multiple successive confounders. Among biomarkers linked with frailty, kynurenine/tryptophan and soluble tumor necrosis factor receptor II were positively associated with T. gondii serointensity in seropositives (p < .05). Associations with other biomarkers were not significant.Conclusions: This first reported association between T. gondii and frailty is limited by a cross-sectional design and warrants replication. While certain biomarkers of inflammaging were associated with both T. gondii IgG serointensity and frailty, they did not fully mediate the T. gondii-frailty association. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023 2024-01-01T00:00:00Z 2024 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/156282 |
url |
https://hdl.handle.net/10216/156282 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1758-535X 1079-5006 10.1093/gerona/glad228 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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