Orbital Metastasis from an Occult Breast Carcinoma (T0, N1, M1)
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/4429 |
Resumo: | The authors report a case of an orbital metastasis from an occult breast carcinoma. A 66-year-old woman presented with a growing left orbital tumour. Orbital CT scan was consistent with lymphoma. However, ocular pathology revealed small neoplastic cells showing an 'indian file pattern' suggestive of metastatic carcinoma and immunohistochemistry was positive for CK7, CK CAM5.2 and oestrogen receptor. A systemic evaluation was then performed with mammogram, breast ultrasound and MRI considered normal. An exhaustive systemic evaluation revealed multiple bone lesions, a right axillary lymph node lesion, which presented the same pattern on pathology and immunohistochemistry, with no evidence of a primary tumour. A diagnosis of a metastatic lobular carcinoma of the breast (T0, N1, M1) was made and the patient was started on chemotherapy and adjuvant hormonal therapy. |
id |
RCAP_31a550ec2b2cbced45aabd1073428aa0 |
---|---|
oai_identifier_str |
oai:repositorio.chlc.min-saude.pt:10400.17/4429 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Orbital Metastasis from an Occult Breast Carcinoma (T0, N1, M1)CHLC OFTAgedFemaleHumansBiomarkers, TumorBiopsyBreast Neoplasms / diagnostic imagingBreast Neoplasms / pathology*Carcinoma, Lobular / diagnostic imagingCarcinoma, Lobular / secondary*Combined Modality TherapyEye Neoplasms / diagnostic imagingEye Neoplasms / pathologyEye Neoplasms / secondary*Eye Neoplasms / therapyKeratin-7 / analysisMagnetic Resonance ImagingMammographyNeoplasms, Unknown Primary / diagnostic imagingNeoplasms, Unknown Primary / pathology*Neoplasms, Unknown Primary / therapyTomography, X-Ray ComputedUltrasonographyWhole Body ImagingThe authors report a case of an orbital metastasis from an occult breast carcinoma. A 66-year-old woman presented with a growing left orbital tumour. Orbital CT scan was consistent with lymphoma. However, ocular pathology revealed small neoplastic cells showing an 'indian file pattern' suggestive of metastatic carcinoma and immunohistochemistry was positive for CK7, CK CAM5.2 and oestrogen receptor. A systemic evaluation was then performed with mammogram, breast ultrasound and MRI considered normal. An exhaustive systemic evaluation revealed multiple bone lesions, a right axillary lymph node lesion, which presented the same pattern on pathology and immunohistochemistry, with no evidence of a primary tumour. A diagnosis of a metastatic lobular carcinoma of the breast (T0, N1, M1) was made and the patient was started on chemotherapy and adjuvant hormonal therapy.BMJRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEPinto Proença, RFernandes, JBurnier, MProença, R2023-03-01T12:31:19Z2018-042018-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4429engBMJ Case Rep . 2018 Apr 11;2018:bcr2017223542.10.1136/bcr-2017-223542info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:46:24Zoai:repositorio.chlc.min-saude.pt:10400.17/4429Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:21:46.992004Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Orbital Metastasis from an Occult Breast Carcinoma (T0, N1, M1) |
title |
Orbital Metastasis from an Occult Breast Carcinoma (T0, N1, M1) |
spellingShingle |
Orbital Metastasis from an Occult Breast Carcinoma (T0, N1, M1) Pinto Proença, R CHLC OFT Aged Female Humans Biomarkers, Tumor Biopsy Breast Neoplasms / diagnostic imaging Breast Neoplasms / pathology* Carcinoma, Lobular / diagnostic imaging Carcinoma, Lobular / secondary* Combined Modality Therapy Eye Neoplasms / diagnostic imaging Eye Neoplasms / pathology Eye Neoplasms / secondary* Eye Neoplasms / therapy Keratin-7 / analysis Magnetic Resonance Imaging Mammography Neoplasms, Unknown Primary / diagnostic imaging Neoplasms, Unknown Primary / pathology* Neoplasms, Unknown Primary / therapy Tomography, X-Ray Computed Ultrasonography Whole Body Imaging |
title_short |
Orbital Metastasis from an Occult Breast Carcinoma (T0, N1, M1) |
title_full |
Orbital Metastasis from an Occult Breast Carcinoma (T0, N1, M1) |
title_fullStr |
Orbital Metastasis from an Occult Breast Carcinoma (T0, N1, M1) |
title_full_unstemmed |
Orbital Metastasis from an Occult Breast Carcinoma (T0, N1, M1) |
title_sort |
Orbital Metastasis from an Occult Breast Carcinoma (T0, N1, M1) |
author |
Pinto Proença, R |
author_facet |
Pinto Proença, R Fernandes, J Burnier, M Proença, R |
author_role |
author |
author2 |
Fernandes, J Burnier, M Proença, R |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Pinto Proença, R Fernandes, J Burnier, M Proença, R |
dc.subject.por.fl_str_mv |
CHLC OFT Aged Female Humans Biomarkers, Tumor Biopsy Breast Neoplasms / diagnostic imaging Breast Neoplasms / pathology* Carcinoma, Lobular / diagnostic imaging Carcinoma, Lobular / secondary* Combined Modality Therapy Eye Neoplasms / diagnostic imaging Eye Neoplasms / pathology Eye Neoplasms / secondary* Eye Neoplasms / therapy Keratin-7 / analysis Magnetic Resonance Imaging Mammography Neoplasms, Unknown Primary / diagnostic imaging Neoplasms, Unknown Primary / pathology* Neoplasms, Unknown Primary / therapy Tomography, X-Ray Computed Ultrasonography Whole Body Imaging |
topic |
CHLC OFT Aged Female Humans Biomarkers, Tumor Biopsy Breast Neoplasms / diagnostic imaging Breast Neoplasms / pathology* Carcinoma, Lobular / diagnostic imaging Carcinoma, Lobular / secondary* Combined Modality Therapy Eye Neoplasms / diagnostic imaging Eye Neoplasms / pathology Eye Neoplasms / secondary* Eye Neoplasms / therapy Keratin-7 / analysis Magnetic Resonance Imaging Mammography Neoplasms, Unknown Primary / diagnostic imaging Neoplasms, Unknown Primary / pathology* Neoplasms, Unknown Primary / therapy Tomography, X-Ray Computed Ultrasonography Whole Body Imaging |
description |
The authors report a case of an orbital metastasis from an occult breast carcinoma. A 66-year-old woman presented with a growing left orbital tumour. Orbital CT scan was consistent with lymphoma. However, ocular pathology revealed small neoplastic cells showing an 'indian file pattern' suggestive of metastatic carcinoma and immunohistochemistry was positive for CK7, CK CAM5.2 and oestrogen receptor. A systemic evaluation was then performed with mammogram, breast ultrasound and MRI considered normal. An exhaustive systemic evaluation revealed multiple bone lesions, a right axillary lymph node lesion, which presented the same pattern on pathology and immunohistochemistry, with no evidence of a primary tumour. A diagnosis of a metastatic lobular carcinoma of the breast (T0, N1, M1) was made and the patient was started on chemotherapy and adjuvant hormonal therapy. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-04 2018-04-01T00:00:00Z 2023-03-01T12:31:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/4429 |
url |
http://hdl.handle.net/10400.17/4429 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMJ Case Rep . 2018 Apr 11;2018:bcr2017223542. 10.1136/bcr-2017-223542 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BMJ |
publisher.none.fl_str_mv |
BMJ |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799131312840245248 |