Solvent modulation in peptide sub-microfibers obtained by solution blow spinning

Detalhes bibliográficos
Autor(a) principal: Dias, Ana Margarida Gonçalves Carvalho
Data de Publicação: 2022
Outros Autores: Cena, Cícero, Lutz-Bueno, Viviane, Mezzenga, Raffaele, Marques, Ana, Ferreira, Isabel, Roque, Ana Cecília Afonso
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/150295
Resumo: This work has received funding from the European Research Council (ERC) for the project SCENT-ERC-2014-STG-639123 (2015–2022), from CNPq (408127/2018-0) and Fundect (71.700.173/2018)-Brazil. project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB.. Publisher Copyright: Copyright © 2022 Dias, Cena, Lutz-Bueno, Mezzenga, Marques, Ferreira and Roque.
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spelling Solvent modulation in peptide sub-microfibers obtained by solution blow spinningpeptide-based fiberspolymeric fibersself-assemblysolution blow-spinningsolvent modulationChemistry(all)This work has received funding from the European Research Council (ERC) for the project SCENT-ERC-2014-STG-639123 (2015–2022), from CNPq (408127/2018-0) and Fundect (71.700.173/2018)-Brazil. project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB.. Publisher Copyright: Copyright © 2022 Dias, Cena, Lutz-Bueno, Mezzenga, Marques, Ferreira and Roque.Peptides possess high chemical diversity at the amino acid sequence level, which further translates into versatile functions. Peptides with self-assembling properties can be processed into diverse formats giving rise to bio-based materials. Peptide-based spun fibers are an interesting format due to high surface-area and versatility, though the field is still in its infancy due to the challenges in applying the synthetic polymer spinning processes to protein fibers to peptides. In this work we show the use of solution blow-spinning to produce peptide fibers. Peptide fiber formation was assisted by the polymer poly (vinyl pyrrolidone) (PVP) in two solvent conditions. Peptide miscibility and further self-assembling propensity in the solvents played a major role in fiber formation. When employing acetic acid as solvent, peptide fibers (0.5 μm) are formed around PVP fibers (0.75 μm), whereas in isopropanol only one type of fibers are formed, consisting of mixed peptide and PVP (1 μm). This report highlights solvent modulation as a mean to obtain different peptide sub-microfibers via a single injection nozzle in solution blow spinning. We anticipate this strategy to be applied to other small peptides with self-assembly propensity to obtain multi-functional proteinaceous fibers.DQ - Departamento de QuímicaUCIBIO - Applied Molecular Biosciences UnitCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisRUNDias, Ana Margarida Gonçalves CarvalhoCena, CíceroLutz-Bueno, VivianeMezzenga, RaffaeleMarques, AnaFerreira, IsabelRoque, Ana Cecília Afonso2023-03-09T22:28:51Z2022-12-062022-12-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://hdl.handle.net/10362/150295engDias, A. M. G. C., Cena, C., Lutz-Bueno, V., Mezzenga, R., Marques, A., Ferreira, I., & Roque, A. C. A. (2022). Solvent modulation in peptide sub-microfibers obtained by solution blow spinning. Frontiers in Chemistry, 10, [1054347]. https://doi.org/10.3389/fchem.2022.10543472296-2646PURE: 55193608https://doi.org/10.3389/fchem.2022.1054347info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:32:12Zoai:run.unl.pt:10362/150295Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:02.451444Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
title Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
spellingShingle Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
Dias, Ana Margarida Gonçalves Carvalho
peptide-based fibers
polymeric fibers
self-assembly
solution blow-spinning
solvent modulation
Chemistry(all)
title_short Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
title_full Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
title_fullStr Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
title_full_unstemmed Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
title_sort Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
author Dias, Ana Margarida Gonçalves Carvalho
author_facet Dias, Ana Margarida Gonçalves Carvalho
Cena, Cícero
Lutz-Bueno, Viviane
Mezzenga, Raffaele
Marques, Ana
Ferreira, Isabel
Roque, Ana Cecília Afonso
author_role author
author2 Cena, Cícero
Lutz-Bueno, Viviane
Mezzenga, Raffaele
Marques, Ana
Ferreira, Isabel
Roque, Ana Cecília Afonso
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
UCIBIO - Applied Molecular Biosciences Unit
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DCM - Departamento de Ciência dos Materiais
RUN
dc.contributor.author.fl_str_mv Dias, Ana Margarida Gonçalves Carvalho
Cena, Cícero
Lutz-Bueno, Viviane
Mezzenga, Raffaele
Marques, Ana
Ferreira, Isabel
Roque, Ana Cecília Afonso
dc.subject.por.fl_str_mv peptide-based fibers
polymeric fibers
self-assembly
solution blow-spinning
solvent modulation
Chemistry(all)
topic peptide-based fibers
polymeric fibers
self-assembly
solution blow-spinning
solvent modulation
Chemistry(all)
description This work has received funding from the European Research Council (ERC) for the project SCENT-ERC-2014-STG-639123 (2015–2022), from CNPq (408127/2018-0) and Fundect (71.700.173/2018)-Brazil. project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB.. Publisher Copyright: Copyright © 2022 Dias, Cena, Lutz-Bueno, Mezzenga, Marques, Ferreira and Roque.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-06
2022-12-06T00:00:00Z
2023-03-09T22:28:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/150295
url http://hdl.handle.net/10362/150295
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dias, A. M. G. C., Cena, C., Lutz-Bueno, V., Mezzenga, R., Marques, A., Ferreira, I., & Roque, A. C. A. (2022). Solvent modulation in peptide sub-microfibers obtained by solution blow spinning. Frontiers in Chemistry, 10, [1054347]. https://doi.org/10.3389/fchem.2022.1054347
2296-2646
PURE: 55193608
https://doi.org/10.3389/fchem.2022.1054347
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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