Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/14676 |
Resumo: | Cynara cardunculus L. (cardoon) has several health benefits mainly attributed to its abundance in polyphenols. In this study, cardoon heads (capitula) were harvested in Greece during the flowering stage, and the hydroethanolic extracts were assessed in terms of phenolic compounds composition and antioxidant, cytotoxic, anti-inflammatory, and antimicrobial activities. The phenolic profile was evaluated by HPLC-DAD-ESI/MS to better understand the seasonal changes in the individual compound levels and how these changes correlate with bioactive properties. The main phenolic compounds identified were caffeoylquinic and dicaffeoylquinic acid derivatives. Immature heads (Car A: principal growth stage (PGS) 5) had the highest phenolic content (34.3 mg/ g) and cytotoxic (GI50 of 69–268 μg/mL) and anti-inflammatory (IC50 of 183 μg/mL) activities. Sample Car D (PGS 6/7) revealed the highest antioxidant (IC50 of 23–227 μg/mL) and antifungal (MIC of 0.26–0.51 mg/mL) potential. Regarding the antibacterial activity, Car E (PGS 7) revealed the best results (MIC of 0.59–1.18 mg/ mL). This study suggests that the maturity stage of the plant influences the phenolic composition and bioactivity. |
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Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilisAnti-inflammatory activityAntimicrobial propertiesBioactive propertiesCynara cardunculus (L.)Phenolic compoundsSeasonal variationCynara cardunculus L. (cardoon) has several health benefits mainly attributed to its abundance in polyphenols. In this study, cardoon heads (capitula) were harvested in Greece during the flowering stage, and the hydroethanolic extracts were assessed in terms of phenolic compounds composition and antioxidant, cytotoxic, anti-inflammatory, and antimicrobial activities. The phenolic profile was evaluated by HPLC-DAD-ESI/MS to better understand the seasonal changes in the individual compound levels and how these changes correlate with bioactive properties. The main phenolic compounds identified were caffeoylquinic and dicaffeoylquinic acid derivatives. Immature heads (Car A: principal growth stage (PGS) 5) had the highest phenolic content (34.3 mg/ g) and cytotoxic (GI50 of 69–268 μg/mL) and anti-inflammatory (IC50 of 183 μg/mL) activities. Sample Car D (PGS 6/7) revealed the highest antioxidant (IC50 of 23–227 μg/mL) and antifungal (MIC of 0.26–0.51 mg/mL) potential. Regarding the antibacterial activity, Car E (PGS 7) revealed the best results (MIC of 0.59–1.18 mg/ mL). This study suggests that the maturity stage of the plant influences the phenolic composition and bioactivity.Biblioteca Digital do IPBMandim, FilipaPetropoulos, Spyridon Α.Giannoulis, Kyriakos D.Dias, Maria InêsFernandes, ÂngelaPinela, JoséKostić, MarinaSoković, MarinaBarros, LillianSantos-Buelga, CelestinoFerreira, Isabel C.F.R.2018-01-19T10:00:00Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/14676engMandim, Filipa; Petropoulos, Spyridon A.; Giannoulis, Kyriakos D.; Dias, Maria Inês; Fernandes, Ângela; Pinela, José; Kostic, Marina; Soković, Marina; Barros, Lillian; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2020). Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis. Food Research International. ISSN 0963-9969. 134, p. 1-80963-996910.1016/j.foodres.2020.109281info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:49:56Zoai:bibliotecadigital.ipb.pt:10198/14676Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:13:31.582570Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis |
title |
Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis |
spellingShingle |
Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis Mandim, Filipa Anti-inflammatory activity Antimicrobial properties Bioactive properties Cynara cardunculus (L.) Phenolic compounds Seasonal variation |
title_short |
Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis |
title_full |
Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis |
title_fullStr |
Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis |
title_full_unstemmed |
Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis |
title_sort |
Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis |
author |
Mandim, Filipa |
author_facet |
Mandim, Filipa Petropoulos, Spyridon Α. Giannoulis, Kyriakos D. Dias, Maria Inês Fernandes, Ângela Pinela, José Kostić, Marina Soković, Marina Barros, Lillian Santos-Buelga, Celestino Ferreira, Isabel C.F.R. |
author_role |
author |
author2 |
Petropoulos, Spyridon Α. Giannoulis, Kyriakos D. Dias, Maria Inês Fernandes, Ângela Pinela, José Kostić, Marina Soković, Marina Barros, Lillian Santos-Buelga, Celestino Ferreira, Isabel C.F.R. |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Mandim, Filipa Petropoulos, Spyridon Α. Giannoulis, Kyriakos D. Dias, Maria Inês Fernandes, Ângela Pinela, José Kostić, Marina Soković, Marina Barros, Lillian Santos-Buelga, Celestino Ferreira, Isabel C.F.R. |
dc.subject.por.fl_str_mv |
Anti-inflammatory activity Antimicrobial properties Bioactive properties Cynara cardunculus (L.) Phenolic compounds Seasonal variation |
topic |
Anti-inflammatory activity Antimicrobial properties Bioactive properties Cynara cardunculus (L.) Phenolic compounds Seasonal variation |
description |
Cynara cardunculus L. (cardoon) has several health benefits mainly attributed to its abundance in polyphenols. In this study, cardoon heads (capitula) were harvested in Greece during the flowering stage, and the hydroethanolic extracts were assessed in terms of phenolic compounds composition and antioxidant, cytotoxic, anti-inflammatory, and antimicrobial activities. The phenolic profile was evaluated by HPLC-DAD-ESI/MS to better understand the seasonal changes in the individual compound levels and how these changes correlate with bioactive properties. The main phenolic compounds identified were caffeoylquinic and dicaffeoylquinic acid derivatives. Immature heads (Car A: principal growth stage (PGS) 5) had the highest phenolic content (34.3 mg/ g) and cytotoxic (GI50 of 69–268 μg/mL) and anti-inflammatory (IC50 of 183 μg/mL) activities. Sample Car D (PGS 6/7) revealed the highest antioxidant (IC50 of 23–227 μg/mL) and antifungal (MIC of 0.26–0.51 mg/mL) potential. Regarding the antibacterial activity, Car E (PGS 7) revealed the best results (MIC of 0.59–1.18 mg/ mL). This study suggests that the maturity stage of the plant influences the phenolic composition and bioactivity. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-19T10:00:00Z 2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/14676 |
url |
http://hdl.handle.net/10198/14676 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mandim, Filipa; Petropoulos, Spyridon A.; Giannoulis, Kyriakos D.; Dias, Maria Inês; Fernandes, Ângela; Pinela, José; Kostic, Marina; Soković, Marina; Barros, Lillian; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2020). Seasonal variation of bioactive properties and phenolic composition of Cynara cardunculus var. altilis. Food Research International. ISSN 0963-9969. 134, p. 1-8 0963-9969 10.1016/j.foodres.2020.109281 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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