NEW METAL-BASED MICELLES AS ANTICANCER AGENTS
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo de conferência |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/19854 |
Resumo: | Cancer is a leader cause of death worldwide. One of the problems associated with the current chemotherapeutic options is the noxious side effects caused by the lack of selectivity. In this frame, our research group has been committed to the development of a new Ru and Fe macrometallodrugs.[1] The data obtained so far shows that these compounds present an intrinsic selectivity towards cancer cells (relatively to healthy cells) due to the incorporation of polymeric ligands that promote a passive targeting through the cancer cell membrane. These results prompted us to the development of new macrometallodrugs bearing bioessential metals such as Fe, Zn and Co. We used a ‘M(bipy) 3 ’ scaffold (bipy = 2,2’-bipyridine derivatives) for the synthesis of the new compounds due to the promising cytotoxicity results observed for related compounds.[2] As polymeric ligands we have chosen the polylactide-co-polyethylene glycol amphiphilic copolymer that is able to self-assemble into micelles in water, keeping the metal center hidden, like a Trojan horse. We will present the synthesis and characterization of the new compounds and some preliminary data on their ability to form stable micelles (Figure 1). |
id |
RCAP_32816347dbbd7f11a6b0d905f3d0601a |
---|---|
oai_identifier_str |
oai:dspace.uevora.pt:10174/19854 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
NEW METAL-BASED MICELLES AS ANTICANCER AGENTSCancer is a leader cause of death worldwide. One of the problems associated with the current chemotherapeutic options is the noxious side effects caused by the lack of selectivity. In this frame, our research group has been committed to the development of a new Ru and Fe macrometallodrugs.[1] The data obtained so far shows that these compounds present an intrinsic selectivity towards cancer cells (relatively to healthy cells) due to the incorporation of polymeric ligands that promote a passive targeting through the cancer cell membrane. These results prompted us to the development of new macrometallodrugs bearing bioessential metals such as Fe, Zn and Co. We used a ‘M(bipy) 3 ’ scaffold (bipy = 2,2’-bipyridine derivatives) for the synthesis of the new compounds due to the promising cytotoxicity results observed for related compounds.[2] As polymeric ligands we have chosen the polylactide-co-polyethylene glycol amphiphilic copolymer that is able to self-assemble into micelles in water, keeping the metal center hidden, like a Trojan horse. We will present the synthesis and characterization of the new compounds and some preliminary data on their ability to form stable micelles (Figure 1).Universidade de Évora2017-01-19T13:03:44Z2017-01-192016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjecthttp://hdl.handle.net/10174/19854http://hdl.handle.net/10174/19854porBebiana Pinto, Ana S. Viana, M. Helena Garcia, Paulo J. Mendes, Andreia Valente. New metal-based micelles as anticancer agents. XII Encontro Nacional de Química Física | 1º Simpósio de Química Computacional, 22-24 June, Évora, Portugal. EP17 p. 109http://12enqf.eventos.chemistry.pt/naonaosimQUIpjgm@uevora.ptbebianapinto9@gmail.commhgarcia@fc.ul.ptamvalente@fc.ul.pt307Mendes, Paulo J.Pinto, BebianaGarcia, M. HelenaValente, Andreiainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:09:13Zoai:dspace.uevora.pt:10174/19854Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:11:24.323421Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
NEW METAL-BASED MICELLES AS ANTICANCER AGENTS |
title |
NEW METAL-BASED MICELLES AS ANTICANCER AGENTS |
spellingShingle |
NEW METAL-BASED MICELLES AS ANTICANCER AGENTS Mendes, Paulo J. |
title_short |
NEW METAL-BASED MICELLES AS ANTICANCER AGENTS |
title_full |
NEW METAL-BASED MICELLES AS ANTICANCER AGENTS |
title_fullStr |
NEW METAL-BASED MICELLES AS ANTICANCER AGENTS |
title_full_unstemmed |
NEW METAL-BASED MICELLES AS ANTICANCER AGENTS |
title_sort |
NEW METAL-BASED MICELLES AS ANTICANCER AGENTS |
author |
Mendes, Paulo J. |
author_facet |
Mendes, Paulo J. Pinto, Bebiana Garcia, M. Helena Valente, Andreia |
author_role |
author |
author2 |
Pinto, Bebiana Garcia, M. Helena Valente, Andreia |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Mendes, Paulo J. Pinto, Bebiana Garcia, M. Helena Valente, Andreia |
description |
Cancer is a leader cause of death worldwide. One of the problems associated with the current chemotherapeutic options is the noxious side effects caused by the lack of selectivity. In this frame, our research group has been committed to the development of a new Ru and Fe macrometallodrugs.[1] The data obtained so far shows that these compounds present an intrinsic selectivity towards cancer cells (relatively to healthy cells) due to the incorporation of polymeric ligands that promote a passive targeting through the cancer cell membrane. These results prompted us to the development of new macrometallodrugs bearing bioessential metals such as Fe, Zn and Co. We used a ‘M(bipy) 3 ’ scaffold (bipy = 2,2’-bipyridine derivatives) for the synthesis of the new compounds due to the promising cytotoxicity results observed for related compounds.[2] As polymeric ligands we have chosen the polylactide-co-polyethylene glycol amphiphilic copolymer that is able to self-assemble into micelles in water, keeping the metal center hidden, like a Trojan horse. We will present the synthesis and characterization of the new compounds and some preliminary data on their ability to form stable micelles (Figure 1). |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01T00:00:00Z 2017-01-19T13:03:44Z 2017-01-19 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/19854 http://hdl.handle.net/10174/19854 |
url |
http://hdl.handle.net/10174/19854 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Bebiana Pinto, Ana S. Viana, M. Helena Garcia, Paulo J. Mendes, Andreia Valente. New metal-based micelles as anticancer agents. XII Encontro Nacional de Química Física | 1º Simpósio de Química Computacional, 22-24 June, Évora, Portugal. EP17 p. 109 http://12enqf.eventos.chemistry.pt/ nao nao sim QUI pjgm@uevora.pt bebianapinto9@gmail.com mhgarcia@fc.ul.pt amvalente@fc.ul.pt 307 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade de Évora |
publisher.none.fl_str_mv |
Universidade de Évora |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799136596083081216 |