The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study

Detalhes bibliográficos
Autor(a) principal: Piotrowska-Tomala, Katarzyna K.
Data de Publicação: 2022
Outros Autores: Jonczyk, Agnieszka W., Szostek-Mioduchowska, Anna Z., Zebrowska, Ewelina, Ferreira-Dias, Graça, Skarzynski, Dariusz J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/24182
Resumo: Research Areas: Veterinary Sciences
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spelling The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo studyProstaglandin E2Human chorion gonadotropin, corpus luteum, progesterone, mareCorpus luteumProgesteroneMareResearch Areas: Veterinary SciencesWe examined the effect of prostaglandin (PG) E2 on the secretory function of equine corpus luteum (CL), according to the application site: intra-CL injection vs. an intrauterine (intra-U) administration. Moreover, the effect of intra-CL injection vs. intra-U administration of both luteotropic factors: PGE2 and human chorionic gonadotropin (hCG) as a positive control, on CL function was additionally compared. Mares were assigned to the groups (n = 6 per group): (1) an intra-CL saline injection (control); (2) an intra-CL injection of PGE2 (5 mg/ml); (3) an intra-CL injection of hCG (1,500 IU/ml); (4) an intra-U saline administration (control); (5) an intra-U administration of PGE2 (5 mg/5 ml); (6) an intra-U administration of hCG (1,500 IU/5 ml). Progesterone (P4) and PGE2 concentrations were measured in blood plasma samples collected at −2, −1, and 0 (pre-treatment), and at 1, 2, 3, 4, 6, 8, 10, 12, and 24 h after treatments. Moreover, effects of different doses of PGE2 application on the concentration of total PGF2α (PGF2α and its main metabolite 13,14-dihydro-15-keto-prostaglandin F2α– PGFM) was determined. The time point of PGE2, hCG, or saline administration was defined as hour “0” of the experiment. An intra-CL injection of PGE2 increased P4 and PGE2 concentrations between 3 and 4 h or at 3 and 12 h, respectively (p < 0.05). While intra-U administration of PGE2 elevated P4 concentrations between 8 and 24 h, PGE2 was upregulated at 1 h and between 3 and 4 h (p < 0.05). An intra-CL injection of hCG increased P4 concentrations at 1, 6, and 12 h (p < 0.05), while its intra-U administration enhanced P4 and PGE2 concentrations between 1 and 12 h or at 3 h and between 6 and 10 h, respectively (p < 0.05). An application of PGE2, dependently on the dose, supports equine CL function, regardless of the application site, consequently leading to differences in both P4 and PGE2 concentrations in blood plasmaFrontiers MediaRepositório da Universidade de LisboaPiotrowska-Tomala, Katarzyna K.Jonczyk, Agnieszka W.Szostek-Mioduchowska, Anna Z.Zebrowska, EwelinaFerreira-Dias, GraçaSkarzynski, Dariusz J.2022-04-27T22:01:08Z2022-02-152022-02-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24182engPiotrowska-Tomala KK, Jonczyk AW, Szostek-Mioduchowska AZ, Zebrowska E, Ferreira-Dias G, Skarzynski DJ. 2022. The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study. Frontiers Veterinary Science, 8:753796. DOI: 10.3389/fvets.2021.75379610.3389/fvets.2021.7537962297-1769info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:53:50Zoai:www.repository.utl.pt:10400.5/24182Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:08:17.358663Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study
title The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study
spellingShingle The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study
Piotrowska-Tomala, Katarzyna K.
Prostaglandin E2
Human chorion gonadotropin, corpus luteum, progesterone, mare
Corpus luteum
Progesterone
Mare
title_short The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study
title_full The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study
title_fullStr The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study
title_full_unstemmed The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study
title_sort The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study
author Piotrowska-Tomala, Katarzyna K.
author_facet Piotrowska-Tomala, Katarzyna K.
Jonczyk, Agnieszka W.
Szostek-Mioduchowska, Anna Z.
Zebrowska, Ewelina
Ferreira-Dias, Graça
Skarzynski, Dariusz J.
author_role author
author2 Jonczyk, Agnieszka W.
Szostek-Mioduchowska, Anna Z.
Zebrowska, Ewelina
Ferreira-Dias, Graça
Skarzynski, Dariusz J.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Piotrowska-Tomala, Katarzyna K.
Jonczyk, Agnieszka W.
Szostek-Mioduchowska, Anna Z.
Zebrowska, Ewelina
Ferreira-Dias, Graça
Skarzynski, Dariusz J.
dc.subject.por.fl_str_mv Prostaglandin E2
Human chorion gonadotropin, corpus luteum, progesterone, mare
Corpus luteum
Progesterone
Mare
topic Prostaglandin E2
Human chorion gonadotropin, corpus luteum, progesterone, mare
Corpus luteum
Progesterone
Mare
description Research Areas: Veterinary Sciences
publishDate 2022
dc.date.none.fl_str_mv 2022-04-27T22:01:08Z
2022-02-15
2022-02-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/24182
url http://hdl.handle.net/10400.5/24182
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Piotrowska-Tomala KK, Jonczyk AW, Szostek-Mioduchowska AZ, Zebrowska E, Ferreira-Dias G, Skarzynski DJ. 2022. The effects of prostaglandin E-2 treatment on the secretory function of mare corpus luteum depends on the site of application : an in vivo study. Frontiers Veterinary Science, 8:753796. DOI: 10.3389/fvets.2021.753796
10.3389/fvets.2021.753796
2297-1769
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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