Development of novel Cu(I) compounds with vitamin B1 derivative and their potential application as anticancer drugs

• Autor(a) principal: Brandão, Paula
• Data de Publicação: 2019
• Outros Autores: Guieu, Samuel, Correia-Branco, Ana, Silva, Cláudia, Martel, Fátima
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10773/37023
• topic: Copper(I); Vitamin B1 derivatives; Thiochrome; Caco-2 cells

The synthesis and crystal structure of two new copper(I) compounds with molecular formula of {Cu4[(µ3-thiocrome)2Cl4]∙2(H2O)}n 1, and Cu2[(µ2-thiocrome)2Cl2] 2 are reported. The crystal structure of compounds 1 and 2 are solved by single crystal X-ray diffraction. The reaction of Cu(II) with thiamine chloride in water at room temperature produces Cu(I) thiochrome compounds 1 and 2. Compound 1 shows a 1D chain structure based on the linkage of two crystallographic different copper centers and thiochrome ligand through the N(1), N(2) and N(3) nitrogen atoms. Compound 2 is a 0D dimeric copper structure assembled by two thiochrome ligands. For both compounds, the copper(I) centers exhibits a distorted trigonal pyramidal geometry. The antitumor capacity of both compounds was tested in vitro against a human cancer cell line, the colorectal adenocarcinoma (Caco-2) cell line, by determining their effect on cell viability. The two compounds showed similar IC50 values, and were slightly more potent than cisplatin, against the same cell line.