Vascular Pathways of Testosterone: Clinical Implications

Detalhes bibliográficos
Autor(a) principal: Lorigo, Margarida
Data de Publicação: 2019
Outros Autores: Mariana, Melissa, Oliveira, Nelson, Lemos, Manuel C., Cairrão, Elisa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/9647
Resumo: Cardiovascular diseases (CVD) are one of the leading causes of death worldwide. Testosterone (T) is an important sex hormone that triggers several genomic and non-genomic pathways, leading to improvements of several cardiovascular risk factors and quality of life in men. At the vascular level, the key effect of T is the vasorelaxation. This review discusses the molecular pathways and clinical implications of T in the vascular system. Firstly, the mechanisms involved in the T vasodilator effect will be presented. Then, it will be discussed the association of T with the main risks for CVD, namely metabolic syndrome, type 2 diabetes mellitus, obesity, atherosclerosis, dyslipidaemia and hypertension. Several studies have shown a correlation between low T levels and an increased prevalence of several CVD. These observations suggest that T has beneficial effects on the cardiovascular system and that testosterone replacement therapy may become a therapeutic reality for some of these disorders.
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spelling Vascular Pathways of Testosterone: Clinical ImplicationsAndrogensVasorelaxationRisk factorsCardiovascular diseasesMetabolic syndromeDiabetes mellitusObesityAtherosclerosisDyslipidaemiaBlood pressureCardiovascular diseases (CVD) are one of the leading causes of death worldwide. Testosterone (T) is an important sex hormone that triggers several genomic and non-genomic pathways, leading to improvements of several cardiovascular risk factors and quality of life in men. At the vascular level, the key effect of T is the vasorelaxation. This review discusses the molecular pathways and clinical implications of T in the vascular system. Firstly, the mechanisms involved in the T vasodilator effect will be presented. Then, it will be discussed the association of T with the main risks for CVD, namely metabolic syndrome, type 2 diabetes mellitus, obesity, atherosclerosis, dyslipidaemia and hypertension. Several studies have shown a correlation between low T levels and an increased prevalence of several CVD. These observations suggest that T has beneficial effects on the cardiovascular system and that testosterone replacement therapy may become a therapeutic reality for some of these disorders.UBI-Santander Totta (BID/FCS/2018)uBibliorumLorigo, MargaridaMariana, MelissaOliveira, NelsonLemos, Manuel C.Cairrão, Elisa2020-03-02T10:38:52Z2019-12-092019-12-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/9647eng10.1007/s12265-019-09939-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-27T12:30:55Zoai:ubibliorum.ubi.pt:10400.6/9647Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-27T12:30:55Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Vascular Pathways of Testosterone: Clinical Implications
title Vascular Pathways of Testosterone: Clinical Implications
spellingShingle Vascular Pathways of Testosterone: Clinical Implications
Lorigo, Margarida
Androgens
Vasorelaxation
Risk factors
Cardiovascular diseases
Metabolic syndrome
Diabetes mellitus
Obesity
Atherosclerosis
Dyslipidaemia
Blood pressure
title_short Vascular Pathways of Testosterone: Clinical Implications
title_full Vascular Pathways of Testosterone: Clinical Implications
title_fullStr Vascular Pathways of Testosterone: Clinical Implications
title_full_unstemmed Vascular Pathways of Testosterone: Clinical Implications
title_sort Vascular Pathways of Testosterone: Clinical Implications
author Lorigo, Margarida
author_facet Lorigo, Margarida
Mariana, Melissa
Oliveira, Nelson
Lemos, Manuel C.
Cairrão, Elisa
author_role author
author2 Mariana, Melissa
Oliveira, Nelson
Lemos, Manuel C.
Cairrão, Elisa
author2_role author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Lorigo, Margarida
Mariana, Melissa
Oliveira, Nelson
Lemos, Manuel C.
Cairrão, Elisa
dc.subject.por.fl_str_mv Androgens
Vasorelaxation
Risk factors
Cardiovascular diseases
Metabolic syndrome
Diabetes mellitus
Obesity
Atherosclerosis
Dyslipidaemia
Blood pressure
topic Androgens
Vasorelaxation
Risk factors
Cardiovascular diseases
Metabolic syndrome
Diabetes mellitus
Obesity
Atherosclerosis
Dyslipidaemia
Blood pressure
description Cardiovascular diseases (CVD) are one of the leading causes of death worldwide. Testosterone (T) is an important sex hormone that triggers several genomic and non-genomic pathways, leading to improvements of several cardiovascular risk factors and quality of life in men. At the vascular level, the key effect of T is the vasorelaxation. This review discusses the molecular pathways and clinical implications of T in the vascular system. Firstly, the mechanisms involved in the T vasodilator effect will be presented. Then, it will be discussed the association of T with the main risks for CVD, namely metabolic syndrome, type 2 diabetes mellitus, obesity, atherosclerosis, dyslipidaemia and hypertension. Several studies have shown a correlation between low T levels and an increased prevalence of several CVD. These observations suggest that T has beneficial effects on the cardiovascular system and that testosterone replacement therapy may become a therapeutic reality for some of these disorders.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-09
2019-12-09T00:00:00Z
2020-03-02T10:38:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/9647
url http://hdl.handle.net/10400.6/9647
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1007/s12265-019-09939-5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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