Light and myopia: from epidemiological studies to neurobiological mechanisms
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/14095 |
Resumo: | Myopia is far beyond its inconvenience and represents a true, highly prevalent, sight-threatening ocular condition, especially in Asia. Without adequate interventions, the current epidemic of myopia is projected to affect 50% of the world population by 2050, becoming the leading cause of irreversible blindness. Although blurred vision, the predominant symptom of myopia, can be improved by contact lenses, glasses, or refractive surgery, corrected myopia, particularly high myopia, still carries the risk of secondary blinding complications such as glaucoma, myopic maculopathy, and retinal detachment, prompting the need for prevention. Epidemiological studies have reported an association between outdoor time and myopia prevention in children. The protective effect of time spent outdoors could be due to the unique characteristics (intensity, spectral distribution, temporal pattern, etc.) of sunlight that is lacking in artificial lighting. Concomitantly, studies in animal models have highlighted the efficacy of light and its components in delaying or even stopping the development of myopia and endeavoured to elucidate possible mechanisms involved in this process. In this narrative review, we (1) summarize the current knowledge concerning light modulation of ocular growth and refractive error development based on studies in human and animal models, (2) summarize potential neurobiological mechanisms involved in the effects of light on ocular growth and emmetropization and (3) highlight a potential pathway for the translational development of noninvasive light-therapy strategies for myopia prevention in children. |
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Light and myopia: from epidemiological studies to neurobiological mechanismsMyopiaLightDopamineAnimal modelNeurobiologyOutdoor activityMyopia is far beyond its inconvenience and represents a true, highly prevalent, sight-threatening ocular condition, especially in Asia. Without adequate interventions, the current epidemic of myopia is projected to affect 50% of the world population by 2050, becoming the leading cause of irreversible blindness. Although blurred vision, the predominant symptom of myopia, can be improved by contact lenses, glasses, or refractive surgery, corrected myopia, particularly high myopia, still carries the risk of secondary blinding complications such as glaucoma, myopic maculopathy, and retinal detachment, prompting the need for prevention. Epidemiological studies have reported an association between outdoor time and myopia prevention in children. The protective effect of time spent outdoors could be due to the unique characteristics (intensity, spectral distribution, temporal pattern, etc.) of sunlight that is lacking in artificial lighting. Concomitantly, studies in animal models have highlighted the efficacy of light and its components in delaying or even stopping the development of myopia and endeavoured to elucidate possible mechanisms involved in this process. In this narrative review, we (1) summarize the current knowledge concerning light modulation of ocular growth and refractive error development based on studies in human and animal models, (2) summarize potential neurobiological mechanisms involved in the effects of light on ocular growth and emmetropization and (3) highlight a potential pathway for the translational development of noninvasive light-therapy strategies for myopia prevention in children.SageRCIPLMuralidharan, Arumugam R.Lança, CarlaBiswas, SayantanBarathi, Veluchamy A.Shermaine, Low W.Seang-Mei, SawMilea, DanNajjar, Raymond P.2021-12-23T12:40:43Z2021-122021-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14095engMuralidharan AR, Lança C, Biswas S, Barathi VA, Shermaine LW, Seang-Mei S, et al. Light and myopia: from epidemiological studies to neuroiological mechanisms. Ther Adv Ophthalmol. 2021;13:1-45.10.1177/25158414211059246info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:09:48Zoai:repositorio.ipl.pt:10400.21/14095Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:21:57.890726Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Light and myopia: from epidemiological studies to neurobiological mechanisms |
title |
Light and myopia: from epidemiological studies to neurobiological mechanisms |
spellingShingle |
Light and myopia: from epidemiological studies to neurobiological mechanisms Muralidharan, Arumugam R. Myopia Light Dopamine Animal model Neurobiology Outdoor activity |
title_short |
Light and myopia: from epidemiological studies to neurobiological mechanisms |
title_full |
Light and myopia: from epidemiological studies to neurobiological mechanisms |
title_fullStr |
Light and myopia: from epidemiological studies to neurobiological mechanisms |
title_full_unstemmed |
Light and myopia: from epidemiological studies to neurobiological mechanisms |
title_sort |
Light and myopia: from epidemiological studies to neurobiological mechanisms |
author |
Muralidharan, Arumugam R. |
author_facet |
Muralidharan, Arumugam R. Lança, Carla Biswas, Sayantan Barathi, Veluchamy A. Shermaine, Low W. Seang-Mei, Saw Milea, Dan Najjar, Raymond P. |
author_role |
author |
author2 |
Lança, Carla Biswas, Sayantan Barathi, Veluchamy A. Shermaine, Low W. Seang-Mei, Saw Milea, Dan Najjar, Raymond P. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Muralidharan, Arumugam R. Lança, Carla Biswas, Sayantan Barathi, Veluchamy A. Shermaine, Low W. Seang-Mei, Saw Milea, Dan Najjar, Raymond P. |
dc.subject.por.fl_str_mv |
Myopia Light Dopamine Animal model Neurobiology Outdoor activity |
topic |
Myopia Light Dopamine Animal model Neurobiology Outdoor activity |
description |
Myopia is far beyond its inconvenience and represents a true, highly prevalent, sight-threatening ocular condition, especially in Asia. Without adequate interventions, the current epidemic of myopia is projected to affect 50% of the world population by 2050, becoming the leading cause of irreversible blindness. Although blurred vision, the predominant symptom of myopia, can be improved by contact lenses, glasses, or refractive surgery, corrected myopia, particularly high myopia, still carries the risk of secondary blinding complications such as glaucoma, myopic maculopathy, and retinal detachment, prompting the need for prevention. Epidemiological studies have reported an association between outdoor time and myopia prevention in children. The protective effect of time spent outdoors could be due to the unique characteristics (intensity, spectral distribution, temporal pattern, etc.) of sunlight that is lacking in artificial lighting. Concomitantly, studies in animal models have highlighted the efficacy of light and its components in delaying or even stopping the development of myopia and endeavoured to elucidate possible mechanisms involved in this process. In this narrative review, we (1) summarize the current knowledge concerning light modulation of ocular growth and refractive error development based on studies in human and animal models, (2) summarize potential neurobiological mechanisms involved in the effects of light on ocular growth and emmetropization and (3) highlight a potential pathway for the translational development of noninvasive light-therapy strategies for myopia prevention in children. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-23T12:40:43Z 2021-12 2021-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/14095 |
url |
http://hdl.handle.net/10400.21/14095 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Muralidharan AR, Lança C, Biswas S, Barathi VA, Shermaine LW, Seang-Mei S, et al. Light and myopia: from epidemiological studies to neuroiological mechanisms. Ther Adv Ophthalmol. 2021;13:1-45. 10.1177/25158414211059246 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Sage |
publisher.none.fl_str_mv |
Sage |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133490967478272 |