Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro Digestion

Detalhes bibliográficos
Autor(a) principal: Bettencourt, Ana
Data de Publicação: 2020
Outros Autores: Gonçalves, L., Gramacho, A., Vieira, A, Rolo, D., Martins, Carla, Assunção, Ricardo, Alvito, Paula, Silva, Maria João, Louro, Henriqueta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/7337
Resumo: Communication
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spelling Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro DigestionNanomaterialsSeveral Metallic Nanomaterials (NMs)CytotoxicityIngested Titanium DioxideStandardized in vitro DigestionSegurança AlimentarAvaliação do RiscoToxicologiaGenotoxicidade AmbientalSaúde HumanaCommunicationSeveral metallic nanomaterials (NMs), such as titanium dioxide nanomaterials (TiO2), present beneficial properties with a broad range of innovative applications. The human population is exposed to TiO2, particularly by ingestion, due to its increasing use as a food additive and inclusion in dietary supplements and food packaging materials. Whether this oral exposure may lead to adverse local or systemic outcomes has been the subject of research, but studies have generated contradictory results, reflecting differences in the physicochemical properties of the TiO2 studied, effects of the surrounding matrix, and modifications during digestion. This work aimed to investigate the toxic effects of three different TiO2 NMs (NM-103, NM-103 and NM-105) on the gastrointestinal tract cells, Caco-2 and HT29-MTX-E12, after the use of the standardized static INFOGEST 2.0 in vitro digestion method to mimic human digestion of TiO2, contributing to hazard assessment. The results show that, for one of the digested TiO2 NMs studied (NM-105), a more pronounced toxicity occurs after exposure of HT29-MTX-E12 intestinal cells, as compared to undigested NM, concomitantly with subtle changes in characteristics of the NM. Thus, the inclusion of the digestion simulation in the safety evaluation of ingested NMs through in vitro bioassays can better integrate the modifications that NMs suffer in the organism. It is expected that such an approach will reduce uncertainties in the hazard assessment of ingested NMs for human health.This research was funded by the Portuguese Foundation for Science and Technology FCT/MCTES through national funds (PIDDAC), PTDC/SAU-PUB/29481/2017 and co-funded by UIDB/00009/2020 (Centre for Toxicogenomics and Human Health—ToxOmics, FCT), iMed.ULisboa (Pest-UID/DTP/04138/2019) and CESAM (UIDP/50017/2020+UIDB/50017/2020), through national funds.MDPIRepositório Científico do Instituto Nacional de SaúdeBettencourt, AnaGonçalves, L.Gramacho, A.Vieira, ARolo, D.Martins, CarlaAssunção, RicardoAlvito, PaulaSilva, Maria JoãoLouro, Henriqueta2021-03-05T16:08:27Z2020-08-022020-08-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7337engNanomaterials (Basel). 2020 Aug 2;10(8):1516. doi: 10.3390/nano100815162079-4991doi:10.3390/nano10081516info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:52Zoai:repositorio.insa.pt:10400.18/7337Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:53.196073Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro Digestion
title Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro Digestion
spellingShingle Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro Digestion
Bettencourt, Ana
Nanomaterials
Several Metallic Nanomaterials (NMs)
Cytotoxicity
Ingested Titanium Dioxide
Standardized in vitro Digestion
Segurança Alimentar
Avaliação do Risco
Toxicologia
Genotoxicidade Ambiental
Saúde Humana
title_short Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro Digestion
title_full Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro Digestion
title_fullStr Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro Digestion
title_full_unstemmed Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro Digestion
title_sort Analysis of the Characteristics and Cytotoxicity of Titanium Dioxide Nanomaterials Following Simulated In Vitro Digestion
author Bettencourt, Ana
author_facet Bettencourt, Ana
Gonçalves, L.
Gramacho, A.
Vieira, A
Rolo, D.
Martins, Carla
Assunção, Ricardo
Alvito, Paula
Silva, Maria João
Louro, Henriqueta
author_role author
author2 Gonçalves, L.
Gramacho, A.
Vieira, A
Rolo, D.
Martins, Carla
Assunção, Ricardo
Alvito, Paula
Silva, Maria João
Louro, Henriqueta
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Bettencourt, Ana
Gonçalves, L.
Gramacho, A.
Vieira, A
Rolo, D.
Martins, Carla
Assunção, Ricardo
Alvito, Paula
Silva, Maria João
Louro, Henriqueta
dc.subject.por.fl_str_mv Nanomaterials
Several Metallic Nanomaterials (NMs)
Cytotoxicity
Ingested Titanium Dioxide
Standardized in vitro Digestion
Segurança Alimentar
Avaliação do Risco
Toxicologia
Genotoxicidade Ambiental
Saúde Humana
topic Nanomaterials
Several Metallic Nanomaterials (NMs)
Cytotoxicity
Ingested Titanium Dioxide
Standardized in vitro Digestion
Segurança Alimentar
Avaliação do Risco
Toxicologia
Genotoxicidade Ambiental
Saúde Humana
description Communication
publishDate 2020
dc.date.none.fl_str_mv 2020-08-02
2020-08-02T00:00:00Z
2021-03-05T16:08:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/7337
url http://hdl.handle.net/10400.18/7337
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nanomaterials (Basel). 2020 Aug 2;10(8):1516. doi: 10.3390/nano10081516
2079-4991
doi:10.3390/nano10081516
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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