Boosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activities

Detalhes bibliográficos
Autor(a) principal: Gomes, Ana
Data de Publicação: 2022
Outros Autores: Bessa, Lucinda J., Fernandes, Iva, Aguiar, Luísa, Ferraz, Ricardo, Monteiro, Cláudia, Martins, M. Cristina L., Mateus, Nuno, Gameiro, Paula, Teixeira, Cátia, Gomes, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/21190
Resumo: Following our previous reports on dual-action antibacterial and collagenesis-inducing hybrid peptide constructs based on “pentapeptide-4” (PP4, with amino acid sequence KTTKS), whose N-palmitoyl derivative is the well-known cosmeceutical ingredient Matrixyl, herein we disclose novel ionic liquid/PP4 conjugates (IL-KTTKS). These conjugates present potent activity against either antibiotic-susceptible strains or multidrug resistant clinical isolates of both Gram-positive and Gram-negative bacterial species belonging to the so-called “ESKAPE” group of pathogens. Noteworthy, their antibacterial activity is preserved in simulated wound fluid, which anticipates an effective action in the setting of a real wound bed. Moreover, their collagenesis-inducing effects in vitro are comparable to or stronger than those of Matrixyl. Altogether, IL-KTTKS exert a triple antibacterial, antifungal, and collagenesis-inducing action in vitro. These findings provide solid grounds for us to advance IL-KTTKS conjugates as promising leads for future development of topical treatments for complicated skin and soft tissue infections (cSSTI). Further studies are envisaged to incorporate IL-conjugates into suitable nanoformulations, to reduce toxicity and/or improve resistance to proteolytic degradation.
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spelling Boosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activitiesAntibacterialAntifungalCollagenesis-inductionCosmeceutical peptidesIonic liquidMatrixylAntimicrobial activityCollagen boostingPentapeptide-4Following our previous reports on dual-action antibacterial and collagenesis-inducing hybrid peptide constructs based on “pentapeptide-4” (PP4, with amino acid sequence KTTKS), whose N-palmitoyl derivative is the well-known cosmeceutical ingredient Matrixyl, herein we disclose novel ionic liquid/PP4 conjugates (IL-KTTKS). These conjugates present potent activity against either antibiotic-susceptible strains or multidrug resistant clinical isolates of both Gram-positive and Gram-negative bacterial species belonging to the so-called “ESKAPE” group of pathogens. Noteworthy, their antibacterial activity is preserved in simulated wound fluid, which anticipates an effective action in the setting of a real wound bed. Moreover, their collagenesis-inducing effects in vitro are comparable to or stronger than those of Matrixyl. Altogether, IL-KTTKS exert a triple antibacterial, antifungal, and collagenesis-inducing action in vitro. These findings provide solid grounds for us to advance IL-KTTKS conjugates as promising leads for future development of topical treatments for complicated skin and soft tissue infections (cSSTI). Further studies are envisaged to incorporate IL-conjugates into suitable nanoformulations, to reduce toxicity and/or improve resistance to proteolytic degradation.ASM JournalsRepositório Científico do Instituto Politécnico do PortoGomes, AnaBessa, Lucinda J.Fernandes, IvaAguiar, LuísaFerraz, RicardoMonteiro, CláudiaMartins, M. Cristina L.Mateus, NunoGameiro, PaulaTeixeira, CátiaGomes, Paula2022-12-13T18:11:23Z2022-08-112022-08-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/21190engGomes, A., Bessa, L. J., Fernandes, I., Aguiar, L., Ferraz, R., Monteiro, C., Martins, M. C. L., Mateus, N., Gameiro, P., Teixeira, C., & Gomes, P. (2022). Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities. Microbiology Spectrum, 10(4), e02291-02221. https://doi.org/doi:10.1128/spectrum.02291-21https://doi.org/10.1128/spectrum.02291-212165-0497metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:17:01Zoai:recipp.ipp.pt:10400.22/21190Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:41:16.108478Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Boosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activities
title Boosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activities
spellingShingle Boosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activities
Gomes, Ana
Antibacterial
Antifungal
Collagenesis-induction
Cosmeceutical peptides
Ionic liquid
Matrixyl
Antimicrobial activity
Collagen boosting
Pentapeptide-4
title_short Boosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activities
title_full Boosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activities
title_fullStr Boosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activities
title_full_unstemmed Boosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activities
title_sort Boosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pentapeptide-4 originates new leads with antimicrobial and collagenesis-inducing activities
author Gomes, Ana
author_facet Gomes, Ana
Bessa, Lucinda J.
Fernandes, Iva
Aguiar, Luísa
Ferraz, Ricardo
Monteiro, Cláudia
Martins, M. Cristina L.
Mateus, Nuno
Gameiro, Paula
Teixeira, Cátia
Gomes, Paula
author_role author
author2 Bessa, Lucinda J.
Fernandes, Iva
Aguiar, Luísa
Ferraz, Ricardo
Monteiro, Cláudia
Martins, M. Cristina L.
Mateus, Nuno
Gameiro, Paula
Teixeira, Cátia
Gomes, Paula
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Gomes, Ana
Bessa, Lucinda J.
Fernandes, Iva
Aguiar, Luísa
Ferraz, Ricardo
Monteiro, Cláudia
Martins, M. Cristina L.
Mateus, Nuno
Gameiro, Paula
Teixeira, Cátia
Gomes, Paula
dc.subject.por.fl_str_mv Antibacterial
Antifungal
Collagenesis-induction
Cosmeceutical peptides
Ionic liquid
Matrixyl
Antimicrobial activity
Collagen boosting
Pentapeptide-4
topic Antibacterial
Antifungal
Collagenesis-induction
Cosmeceutical peptides
Ionic liquid
Matrixyl
Antimicrobial activity
Collagen boosting
Pentapeptide-4
description Following our previous reports on dual-action antibacterial and collagenesis-inducing hybrid peptide constructs based on “pentapeptide-4” (PP4, with amino acid sequence KTTKS), whose N-palmitoyl derivative is the well-known cosmeceutical ingredient Matrixyl, herein we disclose novel ionic liquid/PP4 conjugates (IL-KTTKS). These conjugates present potent activity against either antibiotic-susceptible strains or multidrug resistant clinical isolates of both Gram-positive and Gram-negative bacterial species belonging to the so-called “ESKAPE” group of pathogens. Noteworthy, their antibacterial activity is preserved in simulated wound fluid, which anticipates an effective action in the setting of a real wound bed. Moreover, their collagenesis-inducing effects in vitro are comparable to or stronger than those of Matrixyl. Altogether, IL-KTTKS exert a triple antibacterial, antifungal, and collagenesis-inducing action in vitro. These findings provide solid grounds for us to advance IL-KTTKS conjugates as promising leads for future development of topical treatments for complicated skin and soft tissue infections (cSSTI). Further studies are envisaged to incorporate IL-conjugates into suitable nanoformulations, to reduce toxicity and/or improve resistance to proteolytic degradation.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-13T18:11:23Z
2022-08-11
2022-08-11T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/21190
url http://hdl.handle.net/10400.22/21190
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Gomes, A., Bessa, L. J., Fernandes, I., Aguiar, L., Ferraz, R., Monteiro, C., Martins, M. C. L., Mateus, N., Gameiro, P., Teixeira, C., & Gomes, P. (2022). Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities. Microbiology Spectrum, 10(4), e02291-02221. https://doi.org/doi:10.1128/spectrum.02291-21
https://doi.org/10.1128/spectrum.02291-21
2165-0497
dc.rights.driver.fl_str_mv metadata only access
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dc.publisher.none.fl_str_mv ASM Journals
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