Unravelling Pseudomonas aeruginosa and Candida albicans communication in coinfections scenarios: insights through network analysis

Detalhes bibliográficos
Autor(a) principal: Grainha, Tânia
Data de Publicação: 2020
Outros Autores: Jorge, Paula, Alves, Diana, Lopes, Susana P., Pereira, Maria Olívia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/68203
Resumo: The Supplementary Material for this article canbe found online at: https://www.frontiersin.org/articles/10.3389/fcimb.2020.550505/ full#supplementary-material
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spelling Unravelling Pseudomonas aeruginosa and Candida albicans communication in coinfections scenarios: insights through network analysisPseudomonas aeruginosaCandida albicansBiofilmsPolymicrobialCoinfectioninteractionsdatabaseEngenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e InformáticaScience & TechnologyThe Supplementary Material for this article canbe found online at: https://www.frontiersin.org/articles/10.3389/fcimb.2020.550505/ full#supplementary-materialModern medicine is currently facing huge setbacks concerning infection therapeutics as microorganisms are consistently knocking down every antimicrobial wall set before them. The situation becomes more worrying when taking into account that, in both environmental and disease scenarios, microorganisms present themselves as biofilm communities that are often polymicrobial. This comprises a competitive advantage, with interactions between different species altering host responses, antimicrobial effectiveness, microbial pathogenesis and virulence, usually augmenting the severity of the infection and contributing for the recalcitrance towards conventional therapy. Pseudomonas aeruginosa and Candida albicans are two opportunistic pathogens often co-isolated from infections, mainly from mucosal tissues like the lung. Despite the billions of years of co-existence, this pair of microorganisms is a great example on how little is known about cross-kingdom interactions, particularly within the context of coinfections. Given the described scenario, this study aimed to collect, curate, and analyze all published experimental information on the molecular basis of P. aeruginosa and C. albicans interactions in biofilms, in order to shed light into key mechanisms that may affect infection prognosis, increasing this area of knowledge. Publications were optimally retrieved from PubMed and Web of Science and classified as to their relevance. Data was then systematically and manually curated, analyzed, and further reconstructed as networks. A total of 641 interactions between the two pathogens were annotated, outputting knowledge on important molecular players affecting key virulence mechanisms, such as hyphal growth, and related genes and proteins, constituting potential therapeutic targets for infections related to these bacterial-fungal consortia. Contrasting interactions were also analyzed, and quorum-sensing inhibition approaches were highlighted. All annotated data was made publicly available at www.ceb.uminho.pt/ISCTD, a database already containing similar data for P. aeruginosa and Staphylococcus aureus communication. This will allow researchers to cut on time and effort when studying this particular subject, facilitating the understanding of the basis of the inter-species and inter-kingdom interactions and how it can be modulated to help design alternative and more effective tailored therapies. Finally, data deposition will serve as base for future dataset integration, whose analysis will hopefully give insights into communications in more complex and varied biofilm communities.This work was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2020 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020–Programa Operacional Regional do Norte. The authors also acknowledge COMPETE2020 and FCT for the project POCI-01-0145-FEDER-029841 and FCT for the PhD Grant of TG [grant number SFRH/BD/136544/2018].info:eu-repo/semantics/publishedVersionFrontiers Media S. A.Universidade do MinhoGrainha, TâniaJorge, PaulaAlves, DianaLopes, Susana P.Pereira, Maria Olívia20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/68203engGrainha, Tânia; Jorge, Paula; Alves, Diana; Lopes, Susana P.; Pereira, Maria Olívia, Unravelling Pseudomonas aeruginosa and Candida albicans communication in coinfections scenarios: insights through network analysis. Frontiers in Cellular and Infection Microbiology, 10(550505), 20202235-29882235-298810.3389/fcimb.2020.55050533262953https://www.frontiersin.org/journals/cellular-and-infection-microbiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:29:46Zoai:repositorium.sdum.uminho.pt:1822/68203Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:24:49.007497Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Unravelling Pseudomonas aeruginosa and Candida albicans communication in coinfections scenarios: insights through network analysis
title Unravelling Pseudomonas aeruginosa and Candida albicans communication in coinfections scenarios: insights through network analysis
spellingShingle Unravelling Pseudomonas aeruginosa and Candida albicans communication in coinfections scenarios: insights through network analysis
Grainha, Tânia
Pseudomonas aeruginosa
Candida albicans
Biofilms
Polymicrobial
Coinfection
interactions
database
Engenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e Informática
Science & Technology
title_short Unravelling Pseudomonas aeruginosa and Candida albicans communication in coinfections scenarios: insights through network analysis
title_full Unravelling Pseudomonas aeruginosa and Candida albicans communication in coinfections scenarios: insights through network analysis
title_fullStr Unravelling Pseudomonas aeruginosa and Candida albicans communication in coinfections scenarios: insights through network analysis
title_full_unstemmed Unravelling Pseudomonas aeruginosa and Candida albicans communication in coinfections scenarios: insights through network analysis
title_sort Unravelling Pseudomonas aeruginosa and Candida albicans communication in coinfections scenarios: insights through network analysis
author Grainha, Tânia
author_facet Grainha, Tânia
Jorge, Paula
Alves, Diana
Lopes, Susana P.
Pereira, Maria Olívia
author_role author
author2 Jorge, Paula
Alves, Diana
Lopes, Susana P.
Pereira, Maria Olívia
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Grainha, Tânia
Jorge, Paula
Alves, Diana
Lopes, Susana P.
Pereira, Maria Olívia
dc.subject.por.fl_str_mv Pseudomonas aeruginosa
Candida albicans
Biofilms
Polymicrobial
Coinfection
interactions
database
Engenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e Informática
Science & Technology
topic Pseudomonas aeruginosa
Candida albicans
Biofilms
Polymicrobial
Coinfection
interactions
database
Engenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e Informática
Science & Technology
description The Supplementary Material for this article canbe found online at: https://www.frontiersin.org/articles/10.3389/fcimb.2020.550505/ full#supplementary-material
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/68203
url http://hdl.handle.net/1822/68203
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Grainha, Tânia; Jorge, Paula; Alves, Diana; Lopes, Susana P.; Pereira, Maria Olívia, Unravelling Pseudomonas aeruginosa and Candida albicans communication in coinfections scenarios: insights through network analysis. Frontiers in Cellular and Infection Microbiology, 10(550505), 2020
2235-2988
2235-2988
10.3389/fcimb.2020.550505
33262953
https://www.frontiersin.org/journals/cellular-and-infection-microbiology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S. A.
publisher.none.fl_str_mv Frontiers Media S. A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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