Fanconi syndrome related to zoledronic acid
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000300008 |
Resumo: | Abstract: Fanconi syndrome is characterized by proximal tubular dysfunction, with inability to reabsorb bicarbonate causing type 2 renal tubular acidosis associated with aminoaciduria, normoglycemic glycosuria, hypophosphatemia with phosphaturia and proteinuria. A 68-year-old man with a history of type 2 diabetes mellitus, high-grade papillary carcinoma of the bladder, submitted to transurethral resection in 2011 and 2013 had prostatic adenocarcinoma diagnosed in 2015 with bone metastasis under zoledronic acid. The patient was referred to the emergency department because of anemia de novo and acute on chronic kidney injury. Urinary sediment showed nonnephrotic proteinuria and renal ultrasound was normal. He had hyperchloremic metabolic acidosis with hypokalemia, hypophosphatemia, hypocalcemia, hypouricemia, without glycosuria. No evidence of hemolysis nor abnormalities in serum and urinary immunoelectrophoresis, endoscopic studies, myelogram, or bone marrow biopsy. Renal biopsy was compatible with acute tubular necrosis superimposed on diabetic and hypertensive nephropathy. Zoledronic acid was suspended and we observed slow improvement of renal function and resolution of metabolic acidosis and ionic disorders. Zoledronic acid is nephrotoxic and may induce tubular dysfunction, which can cause Fanconi syndrome. Since 2012, there have been cases relating the administration of zoledronic acid for bone metastasis or hypercalcemia associated with malignant neoplasia with Fanconi syndrome. Although it is a rare association, it is a potentially fatal complication and renal function monitoring is essential. |
id |
RCAP_343ea773953a4773a91d9fe3e54d3bb5 |
---|---|
oai_identifier_str |
oai:scielo:S0872-01692019000300008 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Fanconi syndrome related to zoledronic acidFanconi SyndromeNephrotoxicityRenal tubular acidosisZoledronic AcidAbstract: Fanconi syndrome is characterized by proximal tubular dysfunction, with inability to reabsorb bicarbonate causing type 2 renal tubular acidosis associated with aminoaciduria, normoglycemic glycosuria, hypophosphatemia with phosphaturia and proteinuria. A 68-year-old man with a history of type 2 diabetes mellitus, high-grade papillary carcinoma of the bladder, submitted to transurethral resection in 2011 and 2013 had prostatic adenocarcinoma diagnosed in 2015 with bone metastasis under zoledronic acid. The patient was referred to the emergency department because of anemia de novo and acute on chronic kidney injury. Urinary sediment showed nonnephrotic proteinuria and renal ultrasound was normal. He had hyperchloremic metabolic acidosis with hypokalemia, hypophosphatemia, hypocalcemia, hypouricemia, without glycosuria. No evidence of hemolysis nor abnormalities in serum and urinary immunoelectrophoresis, endoscopic studies, myelogram, or bone marrow biopsy. Renal biopsy was compatible with acute tubular necrosis superimposed on diabetic and hypertensive nephropathy. Zoledronic acid was suspended and we observed slow improvement of renal function and resolution of metabolic acidosis and ionic disorders. Zoledronic acid is nephrotoxic and may induce tubular dysfunction, which can cause Fanconi syndrome. Since 2012, there have been cases relating the administration of zoledronic acid for bone metastasis or hypercalcemia associated with malignant neoplasia with Fanconi syndrome. Although it is a rare association, it is a potentially fatal complication and renal function monitoring is essential.Sociedade Portuguesa de Nefrologia2019-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000300008Portuguese Journal of Nephrology & Hypertension v.33 n.3 2019reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000300008Oliveira,MargaridaSantos,M. TeresaCosta,Anainfo:eu-repo/semantics/openAccess2024-02-06T17:05:03Zoai:scielo:S0872-01692019000300008Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:19:02.828361Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fanconi syndrome related to zoledronic acid |
title |
Fanconi syndrome related to zoledronic acid |
spellingShingle |
Fanconi syndrome related to zoledronic acid Oliveira,Margarida Fanconi Syndrome Nephrotoxicity Renal tubular acidosis Zoledronic Acid |
title_short |
Fanconi syndrome related to zoledronic acid |
title_full |
Fanconi syndrome related to zoledronic acid |
title_fullStr |
Fanconi syndrome related to zoledronic acid |
title_full_unstemmed |
Fanconi syndrome related to zoledronic acid |
title_sort |
Fanconi syndrome related to zoledronic acid |
author |
Oliveira,Margarida |
author_facet |
Oliveira,Margarida Santos,M. Teresa Costa,Ana |
author_role |
author |
author2 |
Santos,M. Teresa Costa,Ana |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Oliveira,Margarida Santos,M. Teresa Costa,Ana |
dc.subject.por.fl_str_mv |
Fanconi Syndrome Nephrotoxicity Renal tubular acidosis Zoledronic Acid |
topic |
Fanconi Syndrome Nephrotoxicity Renal tubular acidosis Zoledronic Acid |
description |
Abstract: Fanconi syndrome is characterized by proximal tubular dysfunction, with inability to reabsorb bicarbonate causing type 2 renal tubular acidosis associated with aminoaciduria, normoglycemic glycosuria, hypophosphatemia with phosphaturia and proteinuria. A 68-year-old man with a history of type 2 diabetes mellitus, high-grade papillary carcinoma of the bladder, submitted to transurethral resection in 2011 and 2013 had prostatic adenocarcinoma diagnosed in 2015 with bone metastasis under zoledronic acid. The patient was referred to the emergency department because of anemia de novo and acute on chronic kidney injury. Urinary sediment showed nonnephrotic proteinuria and renal ultrasound was normal. He had hyperchloremic metabolic acidosis with hypokalemia, hypophosphatemia, hypocalcemia, hypouricemia, without glycosuria. No evidence of hemolysis nor abnormalities in serum and urinary immunoelectrophoresis, endoscopic studies, myelogram, or bone marrow biopsy. Renal biopsy was compatible with acute tubular necrosis superimposed on diabetic and hypertensive nephropathy. Zoledronic acid was suspended and we observed slow improvement of renal function and resolution of metabolic acidosis and ionic disorders. Zoledronic acid is nephrotoxic and may induce tubular dysfunction, which can cause Fanconi syndrome. Since 2012, there have been cases relating the administration of zoledronic acid for bone metastasis or hypercalcemia associated with malignant neoplasia with Fanconi syndrome. Although it is a rare association, it is a potentially fatal complication and renal function monitoring is essential. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000300008 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000300008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000300008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
dc.source.none.fl_str_mv |
Portuguese Journal of Nephrology & Hypertension v.33 n.3 2019 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799137280182452224 |