Fanconi syndrome related to zoledronic acid

Detalhes bibliográficos
Autor(a) principal: Oliveira,Margarida
Data de Publicação: 2019
Outros Autores: Santos,M. Teresa, Costa,Ana
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000300008
Resumo: Abstract: Fanconi syndrome is characterized by proximal tubular dysfunction, with inability to reabsorb bicarbonate causing type 2 renal tubular acidosis associated with aminoaciduria, normoglycemic glycosuria, hypophosphatemia with phosphaturia and proteinuria. A 68-year-old man with a history of type 2 diabetes mellitus, high-grade papillary carcinoma of the bladder, submitted to transurethral resection in 2011 and 2013 had prostatic adenocarcinoma diagnosed in 2015 with bone metastasis under zoledronic acid. The patient was referred to the emergency department because of anemia “de novo” and acute on chronic kidney injury. Urinary sediment showed nonnephrotic proteinuria and renal ultrasound was normal. He had hyperchloremic metabolic acidosis with hypokalemia, hypophosphatemia, hypocalcemia, hypouricemia, without glycosuria. No evidence of hemolysis nor abnormalities in serum and urinary immunoelectrophoresis, endoscopic studies, myelogram, or bone marrow biopsy. Renal biopsy was compatible with acute tubular necrosis superimposed on diabetic and hypertensive nephropathy. Zoledronic acid was suspended and we observed slow improvement of renal function and resolution of metabolic acidosis and ionic disorders. Zoledronic acid is nephrotoxic and may induce tubular dysfunction, which can cause Fanconi syndrome. Since 2012, there have been cases relating the administration of zoledronic acid for bone metastasis or hypercalcemia associated with malignant neoplasia with Fanconi syndrome. Although it is a rare association, it is a potentially fatal complication and renal function monitoring is essential.
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spelling Fanconi syndrome related to zoledronic acidFanconi SyndromeNephrotoxicityRenal tubular acidosisZoledronic AcidAbstract: Fanconi syndrome is characterized by proximal tubular dysfunction, with inability to reabsorb bicarbonate causing type 2 renal tubular acidosis associated with aminoaciduria, normoglycemic glycosuria, hypophosphatemia with phosphaturia and proteinuria. A 68-year-old man with a history of type 2 diabetes mellitus, high-grade papillary carcinoma of the bladder, submitted to transurethral resection in 2011 and 2013 had prostatic adenocarcinoma diagnosed in 2015 with bone metastasis under zoledronic acid. The patient was referred to the emergency department because of anemia “de novo” and acute on chronic kidney injury. Urinary sediment showed nonnephrotic proteinuria and renal ultrasound was normal. He had hyperchloremic metabolic acidosis with hypokalemia, hypophosphatemia, hypocalcemia, hypouricemia, without glycosuria. No evidence of hemolysis nor abnormalities in serum and urinary immunoelectrophoresis, endoscopic studies, myelogram, or bone marrow biopsy. Renal biopsy was compatible with acute tubular necrosis superimposed on diabetic and hypertensive nephropathy. Zoledronic acid was suspended and we observed slow improvement of renal function and resolution of metabolic acidosis and ionic disorders. Zoledronic acid is nephrotoxic and may induce tubular dysfunction, which can cause Fanconi syndrome. Since 2012, there have been cases relating the administration of zoledronic acid for bone metastasis or hypercalcemia associated with malignant neoplasia with Fanconi syndrome. Although it is a rare association, it is a potentially fatal complication and renal function monitoring is essential.Sociedade Portuguesa de Nefrologia2019-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000300008Portuguese Journal of Nephrology & Hypertension v.33 n.3 2019reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000300008Oliveira,MargaridaSantos,M. TeresaCosta,Anainfo:eu-repo/semantics/openAccess2024-02-06T17:05:03Zoai:scielo:S0872-01692019000300008Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:19:02.828361Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Fanconi syndrome related to zoledronic acid
title Fanconi syndrome related to zoledronic acid
spellingShingle Fanconi syndrome related to zoledronic acid
Oliveira,Margarida
Fanconi Syndrome
Nephrotoxicity
Renal tubular acidosis
Zoledronic Acid
title_short Fanconi syndrome related to zoledronic acid
title_full Fanconi syndrome related to zoledronic acid
title_fullStr Fanconi syndrome related to zoledronic acid
title_full_unstemmed Fanconi syndrome related to zoledronic acid
title_sort Fanconi syndrome related to zoledronic acid
author Oliveira,Margarida
author_facet Oliveira,Margarida
Santos,M. Teresa
Costa,Ana
author_role author
author2 Santos,M. Teresa
Costa,Ana
author2_role author
author
dc.contributor.author.fl_str_mv Oliveira,Margarida
Santos,M. Teresa
Costa,Ana
dc.subject.por.fl_str_mv Fanconi Syndrome
Nephrotoxicity
Renal tubular acidosis
Zoledronic Acid
topic Fanconi Syndrome
Nephrotoxicity
Renal tubular acidosis
Zoledronic Acid
description Abstract: Fanconi syndrome is characterized by proximal tubular dysfunction, with inability to reabsorb bicarbonate causing type 2 renal tubular acidosis associated with aminoaciduria, normoglycemic glycosuria, hypophosphatemia with phosphaturia and proteinuria. A 68-year-old man with a history of type 2 diabetes mellitus, high-grade papillary carcinoma of the bladder, submitted to transurethral resection in 2011 and 2013 had prostatic adenocarcinoma diagnosed in 2015 with bone metastasis under zoledronic acid. The patient was referred to the emergency department because of anemia “de novo” and acute on chronic kidney injury. Urinary sediment showed nonnephrotic proteinuria and renal ultrasound was normal. He had hyperchloremic metabolic acidosis with hypokalemia, hypophosphatemia, hypocalcemia, hypouricemia, without glycosuria. No evidence of hemolysis nor abnormalities in serum and urinary immunoelectrophoresis, endoscopic studies, myelogram, or bone marrow biopsy. Renal biopsy was compatible with acute tubular necrosis superimposed on diabetic and hypertensive nephropathy. Zoledronic acid was suspended and we observed slow improvement of renal function and resolution of metabolic acidosis and ionic disorders. Zoledronic acid is nephrotoxic and may induce tubular dysfunction, which can cause Fanconi syndrome. Since 2012, there have been cases relating the administration of zoledronic acid for bone metastasis or hypercalcemia associated with malignant neoplasia with Fanconi syndrome. Although it is a rare association, it is a potentially fatal complication and renal function monitoring is essential.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692019000300008
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.33 n.3 2019
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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