Ketorolac and post-tonsillectomy hemorrhage in pediatric population

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Ana Isabel C.
Data de Publicação: 2020
Outros Autores: Borges Costa, Joana, Duarte, Delfim, Vilhena, Ditza de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.34631/sporl.824
Resumo: Objectives: To assess the risk of post-tonsillectomy hemorrhage associated with the use of ketorolac in children undergoing tonsillectomy. Material and Methods: Retrospective study of children undergoing tonsillectomy between January 2015 and December 2019. Data were collected regarding age, sex, surgical indication, surgery performed, surgical technique, surgeon's experience, hemostasis method, occurrence of postoperative bleeding and its characterization, treatment instituted and the administration or not of ketorolac in the immediate postoperative period.  Results: Included 964 children, 48% female and 52% male, from 2 to 18 years old. Of these, 902 (93.6%) did not receive ketorolac, while 62 (6.4%) received a single dose. The incidence of bleeding in the group with administered ketorolac was 9.7% vs. 4.8% in the group without ketorolac (p = 0.123). The rate of primary bleeding was 50% in the group that took ketorolac vs. 18.6% in the group without ketorolac (p = 0.117). In children with hemorrhage, the need for surgical review of hemostasis was 50% in the group taking ketorolac vs. 18.6% in the group that did not take ketorolac (p = 0.117).  Conclusions: There was no statistically significant impact of the use of ketorolac on postoperative bleeding, although the results tend to point to an increased risk of bleeding. Further studies are needed, namely prospective and with homogeneous groups. 
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spelling Ketorolac and post-tonsillectomy hemorrhage in pediatric populationCetorolac e hemorragia pós-amigdalectomia na população pediátricaketorolactromethamine ketorolactonsillectomypostoperative hemorrhagechildren.childrencetorolaccetorolac de trometaminaamigdalectomiahemorragia pós-operatóriacriançasObjectives: To assess the risk of post-tonsillectomy hemorrhage associated with the use of ketorolac in children undergoing tonsillectomy. Material and Methods: Retrospective study of children undergoing tonsillectomy between January 2015 and December 2019. Data were collected regarding age, sex, surgical indication, surgery performed, surgical technique, surgeon's experience, hemostasis method, occurrence of postoperative bleeding and its characterization, treatment instituted and the administration or not of ketorolac in the immediate postoperative period.  Results: Included 964 children, 48% female and 52% male, from 2 to 18 years old. Of these, 902 (93.6%) did not receive ketorolac, while 62 (6.4%) received a single dose. The incidence of bleeding in the group with administered ketorolac was 9.7% vs. 4.8% in the group without ketorolac (p = 0.123). The rate of primary bleeding was 50% in the group that took ketorolac vs. 18.6% in the group without ketorolac (p = 0.117). In children with hemorrhage, the need for surgical review of hemostasis was 50% in the group taking ketorolac vs. 18.6% in the group that did not take ketorolac (p = 0.117).  Conclusions: There was no statistically significant impact of the use of ketorolac on postoperative bleeding, although the results tend to point to an increased risk of bleeding. Further studies are needed, namely prospective and with homogeneous groups. Objetivos: Avaliar o risco de hemorragia pós-amigdalectomia associada ao uso de cetorolac em crianças submetidas a amigdalectomia.  Material e Métodos: Estudo retrospetivo das crianças submetidas a amigdalectomia entre janeiro de 2015 e dezembro de 2019. Foram recolhidos dados relativos a idade, sexo, indicação cirúrgica, cirurgia realizada, técnica cirúrgica, experiência do cirurgião, método de hemostase, ocorrência de hemorragia pós-operatória e sua caracterização, tratamento instituído e a administração ou não de cetorolac no pós-operatório imediato.  Resultados: Incluídas 964 crianças, 48% do sexo feminino e 52% do sexo masculino, dos 2 aos 18 anos. Destas, 902 (93,6%) não receberam cetorolac, enquanto que 62 (6,4%) receberam dose única. A incidência de hemorragia no grupo a que foi administrado cetorolac foi de 9,7% vs. 4,8% no grupo sem cetorolac (p=0,123). A taxa de hemorragia primária foi de 50% no grupo que fez cetorolac vs. 18,6% no grupo sem cetorolac (p=0,117). Nas crianças com hemorragia, a necessidade de revisão cirúrgica da hemostase foi de 50% no grupo com toma de cetorolac vs. 18,6% no grupo que não fez cetorolac (p=0,117).  Conclusões: Não houve, estatisticamente, um impacto significativo da utilização de cetorolac na hemorragia pós-operatória, embora os resultados tendencialmente apontem para um aumento do risco de hemorragia. São necessários mais estudos, nomeadamente prospetivos e com grupos homogéneos. Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço2020-12-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.34631/sporl.824https://doi.org/10.34631/sporl.824Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 58 No. 4 (2020): December; 181-187Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 58 Núm. 4 (2020): Dezembro; 181-187Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 58 N.º 4 (2020): Dezembro; 181-1872184-6499reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://journalsporl.com/index.php/sporl/article/view/2233https://journalsporl.com/index.php/sporl/article/view/2233/205Direitos de Autor (c) 2020 Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoçoinfo:eu-repo/semantics/openAccessGonçalves, Ana Isabel C.Borges Costa, JoanaDuarte, DelfimVilhena, Ditza de2024-06-06T12:57:30Zoai:journalsporl.com:article/2233Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-06-06T12:57:30Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ketorolac and post-tonsillectomy hemorrhage in pediatric population
Cetorolac e hemorragia pós-amigdalectomia na população pediátrica
title Ketorolac and post-tonsillectomy hemorrhage in pediatric population
spellingShingle Ketorolac and post-tonsillectomy hemorrhage in pediatric population
Gonçalves, Ana Isabel C.
ketorolac
tromethamine ketorolac
tonsillectomy
postoperative hemorrhage
children.
children
cetorolac
cetorolac de trometamina
amigdalectomia
hemorragia pós-operatória
crianças
title_short Ketorolac and post-tonsillectomy hemorrhage in pediatric population
title_full Ketorolac and post-tonsillectomy hemorrhage in pediatric population
title_fullStr Ketorolac and post-tonsillectomy hemorrhage in pediatric population
title_full_unstemmed Ketorolac and post-tonsillectomy hemorrhage in pediatric population
title_sort Ketorolac and post-tonsillectomy hemorrhage in pediatric population
author Gonçalves, Ana Isabel C.
author_facet Gonçalves, Ana Isabel C.
Borges Costa, Joana
Duarte, Delfim
Vilhena, Ditza de
author_role author
author2 Borges Costa, Joana
Duarte, Delfim
Vilhena, Ditza de
author2_role author
author
author
dc.contributor.author.fl_str_mv Gonçalves, Ana Isabel C.
Borges Costa, Joana
Duarte, Delfim
Vilhena, Ditza de
dc.subject.por.fl_str_mv ketorolac
tromethamine ketorolac
tonsillectomy
postoperative hemorrhage
children.
children
cetorolac
cetorolac de trometamina
amigdalectomia
hemorragia pós-operatória
crianças
topic ketorolac
tromethamine ketorolac
tonsillectomy
postoperative hemorrhage
children.
children
cetorolac
cetorolac de trometamina
amigdalectomia
hemorragia pós-operatória
crianças
description Objectives: To assess the risk of post-tonsillectomy hemorrhage associated with the use of ketorolac in children undergoing tonsillectomy. Material and Methods: Retrospective study of children undergoing tonsillectomy between January 2015 and December 2019. Data were collected regarding age, sex, surgical indication, surgery performed, surgical technique, surgeon's experience, hemostasis method, occurrence of postoperative bleeding and its characterization, treatment instituted and the administration or not of ketorolac in the immediate postoperative period.  Results: Included 964 children, 48% female and 52% male, from 2 to 18 years old. Of these, 902 (93.6%) did not receive ketorolac, while 62 (6.4%) received a single dose. The incidence of bleeding in the group with administered ketorolac was 9.7% vs. 4.8% in the group without ketorolac (p = 0.123). The rate of primary bleeding was 50% in the group that took ketorolac vs. 18.6% in the group without ketorolac (p = 0.117). In children with hemorrhage, the need for surgical review of hemostasis was 50% in the group taking ketorolac vs. 18.6% in the group that did not take ketorolac (p = 0.117).  Conclusions: There was no statistically significant impact of the use of ketorolac on postoperative bleeding, although the results tend to point to an increased risk of bleeding. Further studies are needed, namely prospective and with homogeneous groups. 
publishDate 2020
dc.date.none.fl_str_mv 2020-12-05
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.34631/sporl.824
https://doi.org/10.34631/sporl.824
url https://doi.org/10.34631/sporl.824
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://journalsporl.com/index.php/sporl/article/view/2233
https://journalsporl.com/index.php/sporl/article/view/2233/205
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
publisher.none.fl_str_mv Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.source.none.fl_str_mv Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 58 No. 4 (2020): December; 181-187
Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 58 Núm. 4 (2020): Dezembro; 181-187
Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 58 N.º 4 (2020): Dezembro; 181-187
2184-6499
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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