Voltammetric quantification of fluoxetine: application to quality control and quality assurance processes

Detalhes bibliográficos
Autor(a) principal: Lencastre, Rui P.
Data de Publicação: 2006
Outros Autores: Delerue-Matos, Cristina, Garrido, Jorge, Borges, Fernanda, Garrido, E. Manuela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/4204
Resumo: The oxidative behaviour of fluoxetine was studied at a glassy carbon electrode in various buffer systems and at different pH using cyclic, differential pulse and square wave voltammetry. A new square wave voltammetric method suitable for the quality control of fluoxetine in commercial formulations has been developed using a borate pH 9 buffer solution as supporting electrolyte. Under optimized conditions, a linear response was obtained in the range 10 to 16 μM with a detection limit of 1.0 μM. Validation parameters such as sensitivity, precision and accuracy were evaluated. The proposed method was successfully applied to the determination of fluoxetine in pharmaceutical formulations. The results were statistically compared with those obtained by the reference high-performance liquid chromatographic method. No significant differences were found between the methods.
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spelling Voltammetric quantification of fluoxetine: application to quality control and quality assurance processesFluoxetineSquare wave voltammetryOxidationQuality controlPharmaceuticsThe oxidative behaviour of fluoxetine was studied at a glassy carbon electrode in various buffer systems and at different pH using cyclic, differential pulse and square wave voltammetry. A new square wave voltammetric method suitable for the quality control of fluoxetine in commercial formulations has been developed using a borate pH 9 buffer solution as supporting electrolyte. Under optimized conditions, a linear response was obtained in the range 10 to 16 μM with a detection limit of 1.0 μM. Validation parameters such as sensitivity, precision and accuracy were evaluated. The proposed method was successfully applied to the determination of fluoxetine in pharmaceutical formulations. The results were statistically compared with those obtained by the reference high-performance liquid chromatographic method. No significant differences were found between the methods.Food and Drug Administration, Taiwan (TFDA)Repositório Científico do Instituto Politécnico do PortoLencastre, Rui P.Delerue-Matos, CristinaGarrido, JorgeBorges, FernandaGarrido, E. Manuela2014-03-17T15:14:04Z20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/4204eng10.38212/2224-6614.2477info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:44:07Zoai:recipp.ipp.pt:10400.22/4204Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:25:03.947184Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Voltammetric quantification of fluoxetine: application to quality control and quality assurance processes
title Voltammetric quantification of fluoxetine: application to quality control and quality assurance processes
spellingShingle Voltammetric quantification of fluoxetine: application to quality control and quality assurance processes
Lencastre, Rui P.
Fluoxetine
Square wave voltammetry
Oxidation
Quality control
Pharmaceutics
title_short Voltammetric quantification of fluoxetine: application to quality control and quality assurance processes
title_full Voltammetric quantification of fluoxetine: application to quality control and quality assurance processes
title_fullStr Voltammetric quantification of fluoxetine: application to quality control and quality assurance processes
title_full_unstemmed Voltammetric quantification of fluoxetine: application to quality control and quality assurance processes
title_sort Voltammetric quantification of fluoxetine: application to quality control and quality assurance processes
author Lencastre, Rui P.
author_facet Lencastre, Rui P.
Delerue-Matos, Cristina
Garrido, Jorge
Borges, Fernanda
Garrido, E. Manuela
author_role author
author2 Delerue-Matos, Cristina
Garrido, Jorge
Borges, Fernanda
Garrido, E. Manuela
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Lencastre, Rui P.
Delerue-Matos, Cristina
Garrido, Jorge
Borges, Fernanda
Garrido, E. Manuela
dc.subject.por.fl_str_mv Fluoxetine
Square wave voltammetry
Oxidation
Quality control
Pharmaceutics
topic Fluoxetine
Square wave voltammetry
Oxidation
Quality control
Pharmaceutics
description The oxidative behaviour of fluoxetine was studied at a glassy carbon electrode in various buffer systems and at different pH using cyclic, differential pulse and square wave voltammetry. A new square wave voltammetric method suitable for the quality control of fluoxetine in commercial formulations has been developed using a borate pH 9 buffer solution as supporting electrolyte. Under optimized conditions, a linear response was obtained in the range 10 to 16 μM with a detection limit of 1.0 μM. Validation parameters such as sensitivity, precision and accuracy were evaluated. The proposed method was successfully applied to the determination of fluoxetine in pharmaceutical formulations. The results were statistically compared with those obtained by the reference high-performance liquid chromatographic method. No significant differences were found between the methods.
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01T00:00:00Z
2014-03-17T15:14:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/4204
url http://hdl.handle.net/10400.22/4204
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.38212/2224-6614.2477
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Food and Drug Administration, Taiwan (TFDA)
publisher.none.fl_str_mv Food and Drug Administration, Taiwan (TFDA)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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