Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/8793 |
Resumo: | Objective: To investigate potential interactive effects of fine particulate matter (PM2.5) and ozone (O3) on daily mortality at global level. Design: Two stage time series analysis. Setting: 372 cities across 19 countries and regions. Population: Daily counts of deaths from all causes, cardiovascular disease, and respiratory disease. Main outcome measure: Daily mortality data during 1994-2020. Stratified analyses by co-pollutant exposures and synergy index (>1 denotes the combined effect of pollutants is greater than individual effects) were applied to explore the interaction between PM2.5 and O3 in association with mortality. Results: During the study period across the 372 cities, 19.3 million deaths were attributable to all causes, 5.3 million to cardiovascular disease, and 1.9 million to respiratory disease. The risk of total mortality for a 10 μg/m3 increment in PM2.5 (lag 0-1 days) ranged from 0.47% (95% confidence interval 0.26% to 0.67%) to 1.25% (1.02% to 1.48%) from the lowest to highest fourths of O3 concentration; and for a 10 μg/m3 increase in O3 ranged from 0.04% (-0.09% to 0.16%) to 0.29% (0.18% to 0.39%) from the lowest to highest fourths of PM2.5 concentration, with significant differences between strata (P for interaction <0.001). A significant synergistic interaction was also identified between PM2.5 and O3 for total mortality, with a synergy index of 1.93 (95% confidence interval 1.47 to 3.34). Subgroup analyses showed that interactions between PM2.5 and O3 on all three mortality endpoints were more prominent in high latitude regions and during cold seasons. Conclusion: The findings of this study suggest a synergistic effect of PM2.5 and O3 on total, cardiovascular, and respiratory mortality, indicating the benefit of coordinated control strategies for both pollutants. |
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Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysisParticulate MatterOzoneAir PollutionAir PollutantsEnvironmental ExposureMortalityHumansRespiration DisordersCitiesDeterminantes da Saúde e da DoençaEstados de Saúde e de DoençaAvaliação do RiscoObjective: To investigate potential interactive effects of fine particulate matter (PM2.5) and ozone (O3) on daily mortality at global level. Design: Two stage time series analysis. Setting: 372 cities across 19 countries and regions. Population: Daily counts of deaths from all causes, cardiovascular disease, and respiratory disease. Main outcome measure: Daily mortality data during 1994-2020. Stratified analyses by co-pollutant exposures and synergy index (>1 denotes the combined effect of pollutants is greater than individual effects) were applied to explore the interaction between PM2.5 and O3 in association with mortality. Results: During the study period across the 372 cities, 19.3 million deaths were attributable to all causes, 5.3 million to cardiovascular disease, and 1.9 million to respiratory disease. The risk of total mortality for a 10 μg/m3 increment in PM2.5 (lag 0-1 days) ranged from 0.47% (95% confidence interval 0.26% to 0.67%) to 1.25% (1.02% to 1.48%) from the lowest to highest fourths of O3 concentration; and for a 10 μg/m3 increase in O3 ranged from 0.04% (-0.09% to 0.16%) to 0.29% (0.18% to 0.39%) from the lowest to highest fourths of PM2.5 concentration, with significant differences between strata (P for interaction <0.001). A significant synergistic interaction was also identified between PM2.5 and O3 for total mortality, with a synergy index of 1.93 (95% confidence interval 1.47 to 3.34). Subgroup analyses showed that interactions between PM2.5 and O3 on all three mortality endpoints were more prominent in high latitude regions and during cold seasons. Conclusion: The findings of this study suggest a synergistic effect of PM2.5 and O3 on total, cardiovascular, and respiratory mortality, indicating the benefit of coordinated control strategies for both pollutants.HK, RC, and CL were supported by the National Natural Science Foundation of China (92043301, 82030103, and 82103790). FS was supported by the Italian Ministry of University and Research, Department of Excellence project 2023-2027 ReDS “Rethinking Data Science” - Department of Statistics, Computer Science and Applications - University of Florence.BMJ Publishing GroupRepositório Científico do Instituto Nacional de SaúdeLiu, CongChen, RenjieSera, FrancescoVicedo-Cabrera, Ana MariaGuo, YumingTong, ShiluLavigne, EricCorrea, Patricia MatusOrtega, Nicolás ValdésAchilleos, SouzanaRoye, DominicJaakkola, Jouni J.K.Ryti, NiiloPascal, MathildeSchneider, AlexandraBreitner, SusanneEntezari, AlirezaMayvaneh, FatemehRaz, RaananHonda, YasushiHashizume, MasahiroNg, Chris Fook ShengGaio, VâniaMadureira, JoanaHolobaca, Iulian-HoriaTobias, AurelioÍñiguez, CarmenGuo, Yue LeonPan, Shih-ChunMasselot, PierreBell, Michelle L.Zanobetti, AntonellaSchwartz, JoelGasparrini, AntonioKan, Haidong2023-11-28T15:02:54Z2023-10-042023-10-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8793engBMJ. 2023 Oct 4:383:e075203. doi: 10.1136/bmj-2023-075203.1759-215110.1136/bmj-2023-075203info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-02T01:30:31Zoai:repositorio.insa.pt:10400.18/8793Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:40:33.346640Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
title |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
spellingShingle |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis Liu, Cong Particulate Matter Ozone Air Pollution Air Pollutants Environmental Exposure Mortality Humans Respiration Disorders Cities Determinantes da Saúde e da Doença Estados de Saúde e de Doença Avaliação do Risco |
title_short |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
title_full |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
title_fullStr |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
title_full_unstemmed |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
title_sort |
Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities: two stage time series analysis |
author |
Liu, Cong |
author_facet |
Liu, Cong Chen, Renjie Sera, Francesco Vicedo-Cabrera, Ana Maria Guo, Yuming Tong, Shilu Lavigne, Eric Correa, Patricia Matus Ortega, Nicolás Valdés Achilleos, Souzana Roye, Dominic Jaakkola, Jouni J.K. Ryti, Niilo Pascal, Mathilde Schneider, Alexandra Breitner, Susanne Entezari, Alireza Mayvaneh, Fatemeh Raz, Raanan Honda, Yasushi Hashizume, Masahiro Ng, Chris Fook Sheng Gaio, Vânia Madureira, Joana Holobaca, Iulian-Horia Tobias, Aurelio Íñiguez, Carmen Guo, Yue Leon Pan, Shih-Chun Masselot, Pierre Bell, Michelle L. Zanobetti, Antonella Schwartz, Joel Gasparrini, Antonio Kan, Haidong |
author_role |
author |
author2 |
Chen, Renjie Sera, Francesco Vicedo-Cabrera, Ana Maria Guo, Yuming Tong, Shilu Lavigne, Eric Correa, Patricia Matus Ortega, Nicolás Valdés Achilleos, Souzana Roye, Dominic Jaakkola, Jouni J.K. Ryti, Niilo Pascal, Mathilde Schneider, Alexandra Breitner, Susanne Entezari, Alireza Mayvaneh, Fatemeh Raz, Raanan Honda, Yasushi Hashizume, Masahiro Ng, Chris Fook Sheng Gaio, Vânia Madureira, Joana Holobaca, Iulian-Horia Tobias, Aurelio Íñiguez, Carmen Guo, Yue Leon Pan, Shih-Chun Masselot, Pierre Bell, Michelle L. Zanobetti, Antonella Schwartz, Joel Gasparrini, Antonio Kan, Haidong |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Liu, Cong Chen, Renjie Sera, Francesco Vicedo-Cabrera, Ana Maria Guo, Yuming Tong, Shilu Lavigne, Eric Correa, Patricia Matus Ortega, Nicolás Valdés Achilleos, Souzana Roye, Dominic Jaakkola, Jouni J.K. Ryti, Niilo Pascal, Mathilde Schneider, Alexandra Breitner, Susanne Entezari, Alireza Mayvaneh, Fatemeh Raz, Raanan Honda, Yasushi Hashizume, Masahiro Ng, Chris Fook Sheng Gaio, Vânia Madureira, Joana Holobaca, Iulian-Horia Tobias, Aurelio Íñiguez, Carmen Guo, Yue Leon Pan, Shih-Chun Masselot, Pierre Bell, Michelle L. Zanobetti, Antonella Schwartz, Joel Gasparrini, Antonio Kan, Haidong |
dc.subject.por.fl_str_mv |
Particulate Matter Ozone Air Pollution Air Pollutants Environmental Exposure Mortality Humans Respiration Disorders Cities Determinantes da Saúde e da Doença Estados de Saúde e de Doença Avaliação do Risco |
topic |
Particulate Matter Ozone Air Pollution Air Pollutants Environmental Exposure Mortality Humans Respiration Disorders Cities Determinantes da Saúde e da Doença Estados de Saúde e de Doença Avaliação do Risco |
description |
Objective: To investigate potential interactive effects of fine particulate matter (PM2.5) and ozone (O3) on daily mortality at global level. Design: Two stage time series analysis. Setting: 372 cities across 19 countries and regions. Population: Daily counts of deaths from all causes, cardiovascular disease, and respiratory disease. Main outcome measure: Daily mortality data during 1994-2020. Stratified analyses by co-pollutant exposures and synergy index (>1 denotes the combined effect of pollutants is greater than individual effects) were applied to explore the interaction between PM2.5 and O3 in association with mortality. Results: During the study period across the 372 cities, 19.3 million deaths were attributable to all causes, 5.3 million to cardiovascular disease, and 1.9 million to respiratory disease. The risk of total mortality for a 10 μg/m3 increment in PM2.5 (lag 0-1 days) ranged from 0.47% (95% confidence interval 0.26% to 0.67%) to 1.25% (1.02% to 1.48%) from the lowest to highest fourths of O3 concentration; and for a 10 μg/m3 increase in O3 ranged from 0.04% (-0.09% to 0.16%) to 0.29% (0.18% to 0.39%) from the lowest to highest fourths of PM2.5 concentration, with significant differences between strata (P for interaction <0.001). A significant synergistic interaction was also identified between PM2.5 and O3 for total mortality, with a synergy index of 1.93 (95% confidence interval 1.47 to 3.34). Subgroup analyses showed that interactions between PM2.5 and O3 on all three mortality endpoints were more prominent in high latitude regions and during cold seasons. Conclusion: The findings of this study suggest a synergistic effect of PM2.5 and O3 on total, cardiovascular, and respiratory mortality, indicating the benefit of coordinated control strategies for both pollutants. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-28T15:02:54Z 2023-10-04 2023-10-04T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8793 |
url |
http://hdl.handle.net/10400.18/8793 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMJ. 2023 Oct 4:383:e075203. doi: 10.1136/bmj-2023-075203. 1759-2151 10.1136/bmj-2023-075203 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BMJ Publishing Group |
publisher.none.fl_str_mv |
BMJ Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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