Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/32982 |
Resumo: | Affective disorders are common comorbidities of chronic inflammatory pain that are often overlooked in primary care. As the impact of inflammatory pain upon mood-like disorders in animal models is not well known, our objective was to assess whether prolonged experimental monoarthritis (ARTH) induced the development of anxiety and depressive-like behaviours in rodents and if amitriptyline, an antidepressant commonly used in the treatment of chronic pain, could reverse both nociceptive and mood-like impairments. Experimental ARTH was induced through an injection of kaolin/carrageenan into the right knee joint with control (SHAM) animals injected with saline. Four weeks after induction, ARTH animals displayed mechanical hyperalgesia and a depressive-like phenotype as they showed a significant increase in immobility and a decrease in the latency to immobility in the forced-swimming test at the expense of the time spent climbing/swimming. ARTH animals also displayed a decreased sucrose preference, an index of anhedonia and anxiety-like behaviour as time spent exploring the open arms of the elevated-plus-maze was decreased when compared to controls. The anxiety-like phenotype was also supported by an increase in the number of fecal boli left in the open field. In ARTH animals, the administration of amitriptyline decreased mechanical hyperalgesia and increased sucrose preference and the time spent climbing, although it had a deleterious effect in the performance of control animals. Our data show that this model of ARTH can be useful for the study of chronic pain-mood disorders comorbidities and that amitriptyline is able to partly reverse the associated nociceptive and emotional impairments. |
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Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritisExperimental monoarthritisPain-mood disorders comorbidityMechanical hyperalgesiaAmitriptylineScience & TechnologyAffective disorders are common comorbidities of chronic inflammatory pain that are often overlooked in primary care. As the impact of inflammatory pain upon mood-like disorders in animal models is not well known, our objective was to assess whether prolonged experimental monoarthritis (ARTH) induced the development of anxiety and depressive-like behaviours in rodents and if amitriptyline, an antidepressant commonly used in the treatment of chronic pain, could reverse both nociceptive and mood-like impairments. Experimental ARTH was induced through an injection of kaolin/carrageenan into the right knee joint with control (SHAM) animals injected with saline. Four weeks after induction, ARTH animals displayed mechanical hyperalgesia and a depressive-like phenotype as they showed a significant increase in immobility and a decrease in the latency to immobility in the forced-swimming test at the expense of the time spent climbing/swimming. ARTH animals also displayed a decreased sucrose preference, an index of anhedonia and anxiety-like behaviour as time spent exploring the open arms of the elevated-plus-maze was decreased when compared to controls. The anxiety-like phenotype was also supported by an increase in the number of fecal boli left in the open field. In ARTH animals, the administration of amitriptyline decreased mechanical hyperalgesia and increased sucrose preference and the time spent climbing, although it had a deleterious effect in the performance of control animals. Our data show that this model of ARTH can be useful for the study of chronic pain-mood disorders comorbidities and that amitriptyline is able to partly reverse the associated nociceptive and emotional impairments.This study was supported by grants from the Portuguese Science Foundation (FCT) Project no PTDC/SAU-NEU/108557/2008, FEDER-COMPETE, and the Academy of Finland. Diana Amorim was supported by FCT grant SFRH/BD/71219/2010. Ana David-Pereira was supported by FCT grant SFRH/BD/90374/2012.ElsevierUniversidade do MinhoAmorim, DianaPereira, Ana DavidPertovaara, AnttiAlmeida, ArmandoRibeiro, Filipa Pinto20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/32982eng0166-432810.1016/j.bbr.2014.02.00324518202http://www.sciencedirect.com/science/article/pii/S0166432814000709#info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:43:36Zoai:repositorium.sdum.uminho.pt:1822/32982Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:41:06.530032Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis |
title |
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis |
spellingShingle |
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis Amorim, Diana Experimental monoarthritis Pain-mood disorders comorbidity Mechanical hyperalgesia Amitriptyline Science & Technology |
title_short |
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis |
title_full |
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis |
title_fullStr |
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis |
title_full_unstemmed |
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis |
title_sort |
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis |
author |
Amorim, Diana |
author_facet |
Amorim, Diana Pereira, Ana David Pertovaara, Antti Almeida, Armando Ribeiro, Filipa Pinto |
author_role |
author |
author2 |
Pereira, Ana David Pertovaara, Antti Almeida, Armando Ribeiro, Filipa Pinto |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Amorim, Diana Pereira, Ana David Pertovaara, Antti Almeida, Armando Ribeiro, Filipa Pinto |
dc.subject.por.fl_str_mv |
Experimental monoarthritis Pain-mood disorders comorbidity Mechanical hyperalgesia Amitriptyline Science & Technology |
topic |
Experimental monoarthritis Pain-mood disorders comorbidity Mechanical hyperalgesia Amitriptyline Science & Technology |
description |
Affective disorders are common comorbidities of chronic inflammatory pain that are often overlooked in primary care. As the impact of inflammatory pain upon mood-like disorders in animal models is not well known, our objective was to assess whether prolonged experimental monoarthritis (ARTH) induced the development of anxiety and depressive-like behaviours in rodents and if amitriptyline, an antidepressant commonly used in the treatment of chronic pain, could reverse both nociceptive and mood-like impairments. Experimental ARTH was induced through an injection of kaolin/carrageenan into the right knee joint with control (SHAM) animals injected with saline. Four weeks after induction, ARTH animals displayed mechanical hyperalgesia and a depressive-like phenotype as they showed a significant increase in immobility and a decrease in the latency to immobility in the forced-swimming test at the expense of the time spent climbing/swimming. ARTH animals also displayed a decreased sucrose preference, an index of anhedonia and anxiety-like behaviour as time spent exploring the open arms of the elevated-plus-maze was decreased when compared to controls. The anxiety-like phenotype was also supported by an increase in the number of fecal boli left in the open field. In ARTH animals, the administration of amitriptyline decreased mechanical hyperalgesia and increased sucrose preference and the time spent climbing, although it had a deleterious effect in the performance of control animals. Our data show that this model of ARTH can be useful for the study of chronic pain-mood disorders comorbidities and that amitriptyline is able to partly reverse the associated nociceptive and emotional impairments. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/32982 |
url |
http://hdl.handle.net/1822/32982 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0166-4328 10.1016/j.bbr.2014.02.003 24518202 http://www.sciencedirect.com/science/article/pii/S0166432814000709# |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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