Influence of COVID-19 on patients with esophageal varices under prophylactic endoscopic band ligation therapy

Detalhes bibliográficos
Autor(a) principal: Craciun, Ana
Data de Publicação: 2023
Outros Autores: Botto, Inês, Lopes, Joao, Moura, Miguel, Carvalhana, Sofia, Cortez-Pinto, Helena, Marinho, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/64921
Resumo: © 2023 The Author(s). Published by S. Karger AG, Basel. Open Access License. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.
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spelling Influence of COVID-19 on patients with esophageal varices under prophylactic endoscopic band ligation therapyCOVID-19Endoscopic band ligationLiver cirrhosisVariceal eradication© 2023 The Author(s). Published by S. Karger AG, Basel. Open Access License. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.Background and objectives: Endoscopic band ligation (EBL) plays a critical role in patients with clinically significant portal hypertension, as variceal eradication (VE) is essential to prevent further variceal upper gastrointestinal bleeding (GI). The emergence of COVID-19 has led to a dramatic reduction in endoscopic activity. Our study aimed to evaluate the effect of COVID-19 on VE, GI, and 6-month mortality of patients treated with prophylactic EBL therapy. In addition, our goal was to identify the risk factors for our proposed outcomes. Methods: A single-center retrospective cohort study included patients with esophageal varices treated with prophylactic EBL therapy between 2017 and 2021. To demonstrate the impact of COVID-19 on two independent groups on prophylactic EBL therapy with 1 year of follow-up, March 2019 was selected as the cut-off date. Clinical, laboratory, and endoscopic data were recovered from electronic reports. Results: Ninety-seven patients underwent 398 prophylactic EBL sessions, 75 men (77.3%) with mean age 59 ± 12 years. Most achieved VE (60.8%), 14.4% had GI bleeding post-therapy, and 15.5% died at 6 months. The rate of variceal obliteration was significantly lower in the pandemic group (40.9% vs. 77.4% in the pre-pandemic group, p = 0.001). Mean number of EBL sessions and pandemic group were independently associated with incomplete VE, while MELD-Na, portal vein thrombosis and failed VE were identified as risk factors associated with mortality at 6 months. Conclusions: Almost 60% of patients in the pandemic group failed to eradicate esophageal varices. Failure to achieve this result conferred a higher risk of GI bleeding and death at 6 months, the latter also significantly associated with the MELD-Na score and portal vein thrombosis. Our study is among the first to demonstrate the impact of COVID-19 in patients receiving prophylactic EBL therapy.KargerRepositório da Universidade de LisboaCraciun, AnaBotto, InêsLopes, JoaoMoura, MiguelCarvalhana, SofiaCortez-Pinto, HelenaMarinho, Rui2024-05-29T14:53:32Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/64921engGE Port J Gastroenterol. 2023 Jul 19;31(3):182-1902341-454510.1159/0005311352387-1954info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:30:33Zoai:repositorio.ul.pt:10451/64921Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:30:33Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Influence of COVID-19 on patients with esophageal varices under prophylactic endoscopic band ligation therapy
title Influence of COVID-19 on patients with esophageal varices under prophylactic endoscopic band ligation therapy
spellingShingle Influence of COVID-19 on patients with esophageal varices under prophylactic endoscopic band ligation therapy
Craciun, Ana
COVID-19
Endoscopic band ligation
Liver cirrhosis
Variceal eradication
title_short Influence of COVID-19 on patients with esophageal varices under prophylactic endoscopic band ligation therapy
title_full Influence of COVID-19 on patients with esophageal varices under prophylactic endoscopic band ligation therapy
title_fullStr Influence of COVID-19 on patients with esophageal varices under prophylactic endoscopic band ligation therapy
title_full_unstemmed Influence of COVID-19 on patients with esophageal varices under prophylactic endoscopic band ligation therapy
title_sort Influence of COVID-19 on patients with esophageal varices under prophylactic endoscopic band ligation therapy
author Craciun, Ana
author_facet Craciun, Ana
Botto, Inês
Lopes, Joao
Moura, Miguel
Carvalhana, Sofia
Cortez-Pinto, Helena
Marinho, Rui
author_role author
author2 Botto, Inês
Lopes, Joao
Moura, Miguel
Carvalhana, Sofia
Cortez-Pinto, Helena
Marinho, Rui
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Craciun, Ana
Botto, Inês
Lopes, Joao
Moura, Miguel
Carvalhana, Sofia
Cortez-Pinto, Helena
Marinho, Rui
dc.subject.por.fl_str_mv COVID-19
Endoscopic band ligation
Liver cirrhosis
Variceal eradication
topic COVID-19
Endoscopic band ligation
Liver cirrhosis
Variceal eradication
description © 2023 The Author(s). Published by S. Karger AG, Basel. Open Access License. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01T00:00:00Z
2024-05-29T14:53:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/64921
url http://hdl.handle.net/10451/64921
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv GE Port J Gastroenterol. 2023 Jul 19;31(3):182-190
2341-4545
10.1159/000531135
2387-1954
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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