Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/7403 |
Resumo: | Early cancer detection is a major factor in the reduction of mortality and cancer management cost. Here we developed a smart and targeted micelle-based contrast agent for magnetic resonance imaging (MRI), able to turn on its imaging capability in the presence of acidic cancer tissues. This smart contrast agent consists of pH-sensitive polymeric micelles formed by self-assembly of a diblock copolymer (poly(ethyleneglycol-b-trimethylsilyl methacrylate)), loaded with a gadolinium hydrophobic complex ((t)BuBipyGd) and exploits the acidic pH in cancer tissues. In vitro MRI experiments showed that (t)BuBipyGd-loaded micelles were pH-sensitive, as they turned on their imaging capability only in an acidic microenvironment. The micelle-targeting ability toward cancer cells was enhanced by conjugation with an antibody against the MUC1 protein. The ability of our antibody-decorated micelles to be switched on in acidic microenvironments and to target cancer cells expressing specific antigens, together with its high Gd(III) content and its small size (35-40 nm) reveals their potential use for early cancer detection by MRI. |
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Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imagingMicellePH-sensitiveSelf-assemblySmart contrast agentCancer detectionEarly cancer detection is a major factor in the reduction of mortality and cancer management cost. Here we developed a smart and targeted micelle-based contrast agent for magnetic resonance imaging (MRI), able to turn on its imaging capability in the presence of acidic cancer tissues. This smart contrast agent consists of pH-sensitive polymeric micelles formed by self-assembly of a diblock copolymer (poly(ethyleneglycol-b-trimethylsilyl methacrylate)), loaded with a gadolinium hydrophobic complex ((t)BuBipyGd) and exploits the acidic pH in cancer tissues. In vitro MRI experiments showed that (t)BuBipyGd-loaded micelles were pH-sensitive, as they turned on their imaging capability only in an acidic microenvironment. The micelle-targeting ability toward cancer cells was enhanced by conjugation with an antibody against the MUC1 protein. The ability of our antibody-decorated micelles to be switched on in acidic microenvironments and to target cancer cells expressing specific antigens, together with its high Gd(III) content and its small size (35-40 nm) reveals their potential use for early cancer detection by MRI.American Society for NanomedicineSapientiaMouffouk, FouziDornelle, DanielLopes, Andre D.Martins, JorgeAbu-Salah, KhalidCosta, Ana M. Rosa dados Santos, NunoSau, PabloSimão, TeresaAlrokayan, Salman A.2016-01-07T16:52:36Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/7403engInt. J. Nanomedicine (2015) 10, 63-761176-9114AUT: AMC01695; ADL01681;10.2147/IJN.S71190info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:18:31Zoai:sapientia.ualg.pt:10400.1/7403Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:59:47.634205Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging |
title |
Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging |
spellingShingle |
Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging Mouffouk, Fouzi Micelle PH-sensitive Self-assembly Smart contrast agent Cancer detection |
title_short |
Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging |
title_full |
Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging |
title_fullStr |
Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging |
title_full_unstemmed |
Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging |
title_sort |
Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging |
author |
Mouffouk, Fouzi |
author_facet |
Mouffouk, Fouzi Dornelle, Daniel Lopes, Andre D. Martins, Jorge Abu-Salah, Khalid Costa, Ana M. Rosa da dos Santos, Nuno Sau, Pablo Simão, Teresa Alrokayan, Salman A. |
author_role |
author |
author2 |
Dornelle, Daniel Lopes, Andre D. Martins, Jorge Abu-Salah, Khalid Costa, Ana M. Rosa da dos Santos, Nuno Sau, Pablo Simão, Teresa Alrokayan, Salman A. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Mouffouk, Fouzi Dornelle, Daniel Lopes, Andre D. Martins, Jorge Abu-Salah, Khalid Costa, Ana M. Rosa da dos Santos, Nuno Sau, Pablo Simão, Teresa Alrokayan, Salman A. |
dc.subject.por.fl_str_mv |
Micelle PH-sensitive Self-assembly Smart contrast agent Cancer detection |
topic |
Micelle PH-sensitive Self-assembly Smart contrast agent Cancer detection |
description |
Early cancer detection is a major factor in the reduction of mortality and cancer management cost. Here we developed a smart and targeted micelle-based contrast agent for magnetic resonance imaging (MRI), able to turn on its imaging capability in the presence of acidic cancer tissues. This smart contrast agent consists of pH-sensitive polymeric micelles formed by self-assembly of a diblock copolymer (poly(ethyleneglycol-b-trimethylsilyl methacrylate)), loaded with a gadolinium hydrophobic complex ((t)BuBipyGd) and exploits the acidic pH in cancer tissues. In vitro MRI experiments showed that (t)BuBipyGd-loaded micelles were pH-sensitive, as they turned on their imaging capability only in an acidic microenvironment. The micelle-targeting ability toward cancer cells was enhanced by conjugation with an antibody against the MUC1 protein. The ability of our antibody-decorated micelles to be switched on in acidic microenvironments and to target cancer cells expressing specific antigens, together with its high Gd(III) content and its small size (35-40 nm) reveals their potential use for early cancer detection by MRI. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z 2016-01-07T16:52:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/7403 |
url |
http://hdl.handle.net/10400.1/7403 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Int. J. Nanomedicine (2015) 10, 63-76 1176-9114 AUT: AMC01695; ADL01681; 10.2147/IJN.S71190 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Society for Nanomedicine |
publisher.none.fl_str_mv |
American Society for Nanomedicine |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133221961596928 |