Adaptive mechanisms of resistance to antineoplastic agents
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/13354 |
Resumo: | Intrinsic and acquired resistance to conventional and targeted therapeutics is a fundamental reason for treatment failure in many cancer patients. Targeted approaches to overcome chemoresistance as well as resistance to targeted approaches require in depth understanding of the underlying molecular mechanisms. The anti-cancer activity of a drug can be limited by a broad variety of molecular events at different levels of drug action in a cell-autonomous and non-cell-autonomous manner. This review summarizes recent insights into the adaptive mechanisms used by tumours to resist therapy including cellular phenotypic plasticity, dynamic alterations of the tumour microenvironment, activation of redundant signal transduction pathways, modulation of drug target expression levels, and exploitation of pro-survival responses. |
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Adaptive mechanisms of resistance to antineoplastic agentsTo-mesenchymal transitionReceptor tyrosine kinasesDna-damage responseBreast-cancer CcllsAcute myelogenous leukemiaDrug-resistanceTumor microenvironmentMultidrug-resistanceOvarian-cancerUp-RrulationIntrinsic and acquired resistance to conventional and targeted therapeutics is a fundamental reason for treatment failure in many cancer patients. Targeted approaches to overcome chemoresistance as well as resistance to targeted approaches require in depth understanding of the underlying molecular mechanisms. The anti-cancer activity of a drug can be limited by a broad variety of molecular events at different levels of drug action in a cell-autonomous and non-cell-autonomous manner. This review summarizes recent insights into the adaptive mechanisms used by tumours to resist therapy including cellular phenotypic plasticity, dynamic alterations of the tumour microenvironment, activation of redundant signal transduction pathways, modulation of drug target expression levels, and exploitation of pro-survival responses.Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/BPD/100434/2014]Research Center Grant Centre for Biomedical Research [UID/BIM/04773/2013, 1334]Norwegian Research CouncilNorwegian Cancer Society and Helse Vest Health AuthorityProRegem grant [PD/BD/114258/2016]Royal Soc ChemistrySapientiaFerreira, BibianaLie, Maria K.Engelsen, Agnete S. T.Machado, SusanaLink, WolfgangLorens, James B.2019-11-20T15:08:05Z2017-012017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/13354eng2040-250310.1039/c6md00394jinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:25:27Zoai:sapientia.ualg.pt:10400.1/13354Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:04:31.150756Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Adaptive mechanisms of resistance to antineoplastic agents |
title |
Adaptive mechanisms of resistance to antineoplastic agents |
spellingShingle |
Adaptive mechanisms of resistance to antineoplastic agents Ferreira, Bibiana To-mesenchymal transition Receptor tyrosine kinases Dna-damage response Breast-cancer Cclls Acute myelogenous leukemia Drug-resistance Tumor microenvironment Multidrug-resistance Ovarian-cancer Up-Rrulation |
title_short |
Adaptive mechanisms of resistance to antineoplastic agents |
title_full |
Adaptive mechanisms of resistance to antineoplastic agents |
title_fullStr |
Adaptive mechanisms of resistance to antineoplastic agents |
title_full_unstemmed |
Adaptive mechanisms of resistance to antineoplastic agents |
title_sort |
Adaptive mechanisms of resistance to antineoplastic agents |
author |
Ferreira, Bibiana |
author_facet |
Ferreira, Bibiana Lie, Maria K. Engelsen, Agnete S. T. Machado, Susana Link, Wolfgang Lorens, James B. |
author_role |
author |
author2 |
Lie, Maria K. Engelsen, Agnete S. T. Machado, Susana Link, Wolfgang Lorens, James B. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Ferreira, Bibiana Lie, Maria K. Engelsen, Agnete S. T. Machado, Susana Link, Wolfgang Lorens, James B. |
dc.subject.por.fl_str_mv |
To-mesenchymal transition Receptor tyrosine kinases Dna-damage response Breast-cancer Cclls Acute myelogenous leukemia Drug-resistance Tumor microenvironment Multidrug-resistance Ovarian-cancer Up-Rrulation |
topic |
To-mesenchymal transition Receptor tyrosine kinases Dna-damage response Breast-cancer Cclls Acute myelogenous leukemia Drug-resistance Tumor microenvironment Multidrug-resistance Ovarian-cancer Up-Rrulation |
description |
Intrinsic and acquired resistance to conventional and targeted therapeutics is a fundamental reason for treatment failure in many cancer patients. Targeted approaches to overcome chemoresistance as well as resistance to targeted approaches require in depth understanding of the underlying molecular mechanisms. The anti-cancer activity of a drug can be limited by a broad variety of molecular events at different levels of drug action in a cell-autonomous and non-cell-autonomous manner. This review summarizes recent insights into the adaptive mechanisms used by tumours to resist therapy including cellular phenotypic plasticity, dynamic alterations of the tumour microenvironment, activation of redundant signal transduction pathways, modulation of drug target expression levels, and exploitation of pro-survival responses. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01 2017-01-01T00:00:00Z 2019-11-20T15:08:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/13354 |
url |
http://hdl.handle.net/10400.1/13354 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2040-2503 10.1039/c6md00394j |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Royal Soc Chemistry |
publisher.none.fl_str_mv |
Royal Soc Chemistry |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133282200190976 |