Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems

Detalhes bibliográficos
Autor(a) principal: Souto, Eliana B.
Data de Publicação: 2019
Outros Autores: Dias-Ferreira, João, Craveiro, Sara A., Severino, Patrícia, Sanchez-Lopez, Elena, Garcia, Maria L., Silva, Amélia M., Souto, Selma B., Mahant, Sheefali
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/61139
Resumo: The incidence of neglected diseases in tropical countries, such as Leishmaniasis and Chagass disease, is attributed to a set of biological and ecological factors associated with the socioeconomic context of developing countries and with a significant burden to health care systems. Both Leishmaniasis and Chagass disease are caused by different protozoa and develop diverse symptoms, which depend on the specific species infecting man. Currently available drugs to treat these disorders have limited therapeutic outcomes, frequently due to microorganisms drug resistance. In recent years, significant efforts have been made towards the development of innovative drug delivery systems aiming to improve bioavailability and pharmacokinetic profiles of classical drug therapy. This paper discusses the key facts of Leishmaniasis and Chagass disease, the currently available pharmacological therapies and the new drug delivery systems for conventional drugs.
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spelling Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systemsNeglected diseasesdrug delivery systemsantiprotozoal agentsChagass diseaseleishmaniasisChagas's diseaseScience & TechnologyThe incidence of neglected diseases in tropical countries, such as Leishmaniasis and Chagass disease, is attributed to a set of biological and ecological factors associated with the socioeconomic context of developing countries and with a significant burden to health care systems. Both Leishmaniasis and Chagass disease are caused by different protozoa and develop diverse symptoms, which depend on the specific species infecting man. Currently available drugs to treat these disorders have limited therapeutic outcomes, frequently due to microorganisms drug resistance. In recent years, significant efforts have been made towards the development of innovative drug delivery systems aiming to improve bioavailability and pharmacokinetic profiles of classical drug therapy. This paper discusses the key facts of Leishmaniasis and Chagass disease, the currently available pharmacological therapies and the new drug delivery systems for conventional drugs.This research was funded by the Portuguese Science and Technology Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) under the project references M-ERA-NET/0004/2015 (PAIRED) and UID/AGR/04033/2019 (CITAB), co-financed by FEDER, under the Partnership Agreement PT2020.info:eu-repo/semantics/publishedVersionMultidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoSouto, Eliana B.Dias-Ferreira, JoãoCraveiro, Sara A.Severino, PatríciaSanchez-Lopez, ElenaGarcia, Maria L.Silva, Amélia M.Souto, Selma B.Mahant, Sheefali2019-082019-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/61139engSouto, Eliana; Dias-Ferreira, João; Craveiro, Sara A.; Severino, Patrícia; Sanchez-Lopez, Elena; Garcia, Maria L.; Silva, Amélia M.; Souto, Selma B.; Mahant, Sheefali, Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems. Pathogens, 8(3), 119, 2019207608172076081710.3390/pathogens8030119http://www.mdpi.com/journal/pathogensinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:45:46Zoai:repositorium.sdum.uminho.pt:1822/61139Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:43:40.479333Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems
title Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems
spellingShingle Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems
Souto, Eliana B.
Neglected diseases
drug delivery systems
antiprotozoal agents
Chagass disease
leishmaniasis
Chagas's disease
Science & Technology
title_short Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems
title_full Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems
title_fullStr Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems
title_full_unstemmed Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems
title_sort Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems
author Souto, Eliana B.
author_facet Souto, Eliana B.
Dias-Ferreira, João
Craveiro, Sara A.
Severino, Patrícia
Sanchez-Lopez, Elena
Garcia, Maria L.
Silva, Amélia M.
Souto, Selma B.
Mahant, Sheefali
author_role author
author2 Dias-Ferreira, João
Craveiro, Sara A.
Severino, Patrícia
Sanchez-Lopez, Elena
Garcia, Maria L.
Silva, Amélia M.
Souto, Selma B.
Mahant, Sheefali
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Souto, Eliana B.
Dias-Ferreira, João
Craveiro, Sara A.
Severino, Patrícia
Sanchez-Lopez, Elena
Garcia, Maria L.
Silva, Amélia M.
Souto, Selma B.
Mahant, Sheefali
dc.subject.por.fl_str_mv Neglected diseases
drug delivery systems
antiprotozoal agents
Chagass disease
leishmaniasis
Chagas's disease
Science & Technology
topic Neglected diseases
drug delivery systems
antiprotozoal agents
Chagass disease
leishmaniasis
Chagas's disease
Science & Technology
description The incidence of neglected diseases in tropical countries, such as Leishmaniasis and Chagass disease, is attributed to a set of biological and ecological factors associated with the socioeconomic context of developing countries and with a significant burden to health care systems. Both Leishmaniasis and Chagass disease are caused by different protozoa and develop diverse symptoms, which depend on the specific species infecting man. Currently available drugs to treat these disorders have limited therapeutic outcomes, frequently due to microorganisms drug resistance. In recent years, significant efforts have been made towards the development of innovative drug delivery systems aiming to improve bioavailability and pharmacokinetic profiles of classical drug therapy. This paper discusses the key facts of Leishmaniasis and Chagass disease, the currently available pharmacological therapies and the new drug delivery systems for conventional drugs.
publishDate 2019
dc.date.none.fl_str_mv 2019-08
2019-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/61139
url http://hdl.handle.net/1822/61139
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Souto, Eliana; Dias-Ferreira, João; Craveiro, Sara A.; Severino, Patrícia; Sanchez-Lopez, Elena; Garcia, Maria L.; Silva, Amélia M.; Souto, Selma B.; Mahant, Sheefali, Therapeutic interventions for countering Leishmaniasis and Chagas's disease: from traditional sources to nanotechnological systems. Pathogens, 8(3), 119, 2019
20760817
20760817
10.3390/pathogens8030119
http://www.mdpi.com/journal/pathogens
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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