Differences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial Africa

Detalhes bibliográficos
Autor(a) principal: Aguiar, Laura
Data de Publicação: 2021
Outros Autores: Semente, Ildegário, Ferreira, Joana, Carvalho, Andreia, Silva, Alda P., Caroça, Cristina, Caria, Helena, Damasceno, Albertino, Laires, Maria J., Sardinha, Luís, Monteiro, Cristina, Mascarenhas, Mário R., Faustino, Paula, Inácio, Ângela, Bicho, Manuel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/134129
Resumo: Funding Information: The authors are grateful to all study participants and would like to thank the Instituto de Investiga??o Cient?fica Bento da Rocha Cabral for financial support. Publisher Copyright: © 2021 Aguiar L et al.
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spelling Differences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial AfricaAfricaBlood pressureGeneticsMedicine(all)Funding Information: The authors are grateful to all study participants and would like to thank the Instituto de Investiga??o Cient?fica Bento da Rocha Cabral for financial support. Publisher Copyright: © 2021 Aguiar L et al.Background: Since the emergence of the genus Homo, hominids have occupied a wide variety of environments, facing different selective pressures. Objectives: The aim this study is to compare genotype frequencies between South-West Europe and Peri-equatorial Africa in genes potentially modulators of blood pressure. Methods: The analyzed sample consisted of 325 individuals from Portugal and 226 individuals from Africa (48 from Mozambique and 178 from São Tomé and Príncipe). The following genetic variants were analyzed: intron 4 VNTR in eNOS, rs1050829 in G6PD,-3.7kb α-thalassemic deletion in HBA, rs1800457 in CYB5R3, Hp 1/2 genotype/phenotype in Hp and intron 16 I/D in ACE. Results: Frequencies of genotypes with the 4a allele in eNOS (p<0.001), the G allele in G6PD (p<0.001), the α-3.7 kb in HBA (p <0.001), the C allele in the CYB5R3 (p<0.001) were higher in Peri-equatorial Africa. The Hp 1.1 genotype of Hp has a higher frequency in Peri-equatorial Africa (p=0.002). ACE shows no significant differences. Conclusion: Results show differences in five genetic variants. Conditions of extreme heat and humidity, characteristic of Peri-equatorial Africa, have been associated with increased sodium loss. This study suggests that selected compensatory mechanisms printed in the genome, are nowadays risk factors for hypertension in Peri-equatorial Africa.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNAguiar, LauraSemente, IldegárioFerreira, JoanaCarvalho, AndreiaSilva, Alda P.Caroça, CristinaCaria, HelenaDamasceno, AlbertinoLaires, Maria J.Sardinha, LuísMonteiro, CristinaMascarenhas, Mário R.Faustino, PaulaInácio, ÂngelaBicho, Manuel2022-03-08T23:22:59Z2021-12-142021-12-14T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://hdl.handle.net/10362/134129eng1680-6905PURE: 41977587https://doi.org/10.4314/ahs.v21i4.21info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:00:00Zoai:run.unl.pt:10362/134129Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:00Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Differences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial Africa
title Differences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial Africa
spellingShingle Differences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial Africa
Aguiar, Laura
Africa
Blood pressure
Genetics
Medicine(all)
title_short Differences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial Africa
title_full Differences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial Africa
title_fullStr Differences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial Africa
title_full_unstemmed Differences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial Africa
title_sort Differences in the genotype frequencies of genes related to blood pressure regulation-a comparative study between South-West Europe and Peri-equatorial Africa
author Aguiar, Laura
author_facet Aguiar, Laura
Semente, Ildegário
Ferreira, Joana
Carvalho, Andreia
Silva, Alda P.
Caroça, Cristina
Caria, Helena
Damasceno, Albertino
Laires, Maria J.
Sardinha, Luís
Monteiro, Cristina
Mascarenhas, Mário R.
Faustino, Paula
Inácio, Ângela
Bicho, Manuel
author_role author
author2 Semente, Ildegário
Ferreira, Joana
Carvalho, Andreia
Silva, Alda P.
Caroça, Cristina
Caria, Helena
Damasceno, Albertino
Laires, Maria J.
Sardinha, Luís
Monteiro, Cristina
Mascarenhas, Mário R.
Faustino, Paula
Inácio, Ângela
Bicho, Manuel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Aguiar, Laura
Semente, Ildegário
Ferreira, Joana
Carvalho, Andreia
Silva, Alda P.
Caroça, Cristina
Caria, Helena
Damasceno, Albertino
Laires, Maria J.
Sardinha, Luís
Monteiro, Cristina
Mascarenhas, Mário R.
Faustino, Paula
Inácio, Ângela
Bicho, Manuel
dc.subject.por.fl_str_mv Africa
Blood pressure
Genetics
Medicine(all)
topic Africa
Blood pressure
Genetics
Medicine(all)
description Funding Information: The authors are grateful to all study participants and would like to thank the Instituto de Investiga??o Cient?fica Bento da Rocha Cabral for financial support. Publisher Copyright: © 2021 Aguiar L et al.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-14
2021-12-14T00:00:00Z
2022-03-08T23:22:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/134129
url http://hdl.handle.net/10362/134129
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1680-6905
PURE: 41977587
https://doi.org/10.4314/ahs.v21i4.21
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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