Viral Clearance and Serological Response to SARS-CoV-2 in Kidney Transplant Recipients

Detalhes bibliográficos
Autor(a) principal: Silvano, J
Data de Publicação: 2021
Outros Autores: Ferreira, F, Bustorff, M, Nunes, AT, Tavares, I, Sobrinho Simões, J, Ramos, A, Cardoso, MJ, Sampaio, S, Pestana, M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/149517
Resumo: Objectives Knowledge about the impact of coronavirus disease 2019 (COVID-19) on kidney transplant recipients (KTRs) concerning viral shedding and humoral immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is limited. The aim of this study is to analyze viral dynamics and the antibody response to SARS-CoV-2 in KTRs with COVID-19 and study their association with clinical data. Materials and methods Consecutive KTRs diagnosed with COVID-19 at our center were evaluated for clinical presentation and outcome; duration of viral shedding and viral burden by reverse transcription-polymerase chain reaction assay cycle threshold; and magnitude of seroconversion to SARS-CoV-2. Results Six KTRs identified with COVID-19 were hospitalized. Presenting symptoms were similar to those in the general population. Four patients had severe disease and, of these, 2 required mechanical ventilation, 4 had acute kidney injury, and 3 had secondary bacterial infections. Immunosuppression was reduced in all patients. Five patients were treated with hydroxychloroquine. No patient required dialysis or died. Patients with severe disease had a longer duration of viral shedding, which lasted more than 40 days, and had IgG antibodies against SARS-CoV-2, which were detected from 3 weeks to as long as 10 weeks after symptom onset. In patients with less severe disease no IgG antibodies where detected between 9 and 14 weeks after symptom onset. Conclusions In our series, KTRs with severe COVID-19 had prolonged viral shedding and a stronger humoral immune response to SARS-CoV-2. These preliminary data need to be confirmed with further studies and over a longer period of time.
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spelling Viral Clearance and Serological Response to SARS-CoV-2 in Kidney Transplant RecipientsObjectives Knowledge about the impact of coronavirus disease 2019 (COVID-19) on kidney transplant recipients (KTRs) concerning viral shedding and humoral immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is limited. The aim of this study is to analyze viral dynamics and the antibody response to SARS-CoV-2 in KTRs with COVID-19 and study their association with clinical data. Materials and methods Consecutive KTRs diagnosed with COVID-19 at our center were evaluated for clinical presentation and outcome; duration of viral shedding and viral burden by reverse transcription-polymerase chain reaction assay cycle threshold; and magnitude of seroconversion to SARS-CoV-2. Results Six KTRs identified with COVID-19 were hospitalized. Presenting symptoms were similar to those in the general population. Four patients had severe disease and, of these, 2 required mechanical ventilation, 4 had acute kidney injury, and 3 had secondary bacterial infections. Immunosuppression was reduced in all patients. Five patients were treated with hydroxychloroquine. No patient required dialysis or died. Patients with severe disease had a longer duration of viral shedding, which lasted more than 40 days, and had IgG antibodies against SARS-CoV-2, which were detected from 3 weeks to as long as 10 weeks after symptom onset. In patients with less severe disease no IgG antibodies where detected between 9 and 14 weeks after symptom onset. Conclusions In our series, KTRs with severe COVID-19 had prolonged viral shedding and a stronger humoral immune response to SARS-CoV-2. These preliminary data need to be confirmed with further studies and over a longer period of time.Elsevier20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/149517eng0041-13451873-262310.1016/j.transproceed.2020.11.008Silvano, JFerreira, FBustorff, MNunes, ATTavares, ISobrinho Simões, JRamos, ACardoso, MJSampaio, SPestana, Minfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:50:34Zoai:repositorio-aberto.up.pt:10216/149517Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:09:49.088729Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Viral Clearance and Serological Response to SARS-CoV-2 in Kidney Transplant Recipients
title Viral Clearance and Serological Response to SARS-CoV-2 in Kidney Transplant Recipients
spellingShingle Viral Clearance and Serological Response to SARS-CoV-2 in Kidney Transplant Recipients
Silvano, J
title_short Viral Clearance and Serological Response to SARS-CoV-2 in Kidney Transplant Recipients
title_full Viral Clearance and Serological Response to SARS-CoV-2 in Kidney Transplant Recipients
title_fullStr Viral Clearance and Serological Response to SARS-CoV-2 in Kidney Transplant Recipients
title_full_unstemmed Viral Clearance and Serological Response to SARS-CoV-2 in Kidney Transplant Recipients
title_sort Viral Clearance and Serological Response to SARS-CoV-2 in Kidney Transplant Recipients
author Silvano, J
author_facet Silvano, J
Ferreira, F
Bustorff, M
Nunes, AT
Tavares, I
Sobrinho Simões, J
Ramos, A
Cardoso, MJ
Sampaio, S
Pestana, M
author_role author
author2 Ferreira, F
Bustorff, M
Nunes, AT
Tavares, I
Sobrinho Simões, J
Ramos, A
Cardoso, MJ
Sampaio, S
Pestana, M
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silvano, J
Ferreira, F
Bustorff, M
Nunes, AT
Tavares, I
Sobrinho Simões, J
Ramos, A
Cardoso, MJ
Sampaio, S
Pestana, M
description Objectives Knowledge about the impact of coronavirus disease 2019 (COVID-19) on kidney transplant recipients (KTRs) concerning viral shedding and humoral immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is limited. The aim of this study is to analyze viral dynamics and the antibody response to SARS-CoV-2 in KTRs with COVID-19 and study their association with clinical data. Materials and methods Consecutive KTRs diagnosed with COVID-19 at our center were evaluated for clinical presentation and outcome; duration of viral shedding and viral burden by reverse transcription-polymerase chain reaction assay cycle threshold; and magnitude of seroconversion to SARS-CoV-2. Results Six KTRs identified with COVID-19 were hospitalized. Presenting symptoms were similar to those in the general population. Four patients had severe disease and, of these, 2 required mechanical ventilation, 4 had acute kidney injury, and 3 had secondary bacterial infections. Immunosuppression was reduced in all patients. Five patients were treated with hydroxychloroquine. No patient required dialysis or died. Patients with severe disease had a longer duration of viral shedding, which lasted more than 40 days, and had IgG antibodies against SARS-CoV-2, which were detected from 3 weeks to as long as 10 weeks after symptom onset. In patients with less severe disease no IgG antibodies where detected between 9 and 14 weeks after symptom onset. Conclusions In our series, KTRs with severe COVID-19 had prolonged viral shedding and a stronger humoral immune response to SARS-CoV-2. These preliminary data need to be confirmed with further studies and over a longer period of time.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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1873-2623
10.1016/j.transproceed.2020.11.008
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