Relationship between left ventricular function and uptake indexes myocardium/lung in Gated-SPECT studies

• Autor(a) principal: Correia, Raquel
• Data de Publicação: 2022
• Outros Autores: Carolino, Elisabete, Vieira, Lina
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://doi.org/10.25758/set.954
• topic: Gated-SPECT; Fração de ejeção ventricular esquerda; Índice de captação miocárdio/Pulmão; Enfarte agudo do miocárdio; Isquémia; Gated-SPECT; Left ventricular ejection fraction; Uptake indexes myocardium/Lung; Acute myocardial infarction; Ischaemia

Introduction – Single Photon Emission Computed Tomography synchronized with the electrocardiographic signal (Gated-SPECT) is central to the joint assessment of perfusion and left ventricular (LV) myocardial function. Objectives – Explore the relationship between LV function and uptake indexes (UI) Miocardium/Right Lung (M/RL) and M/Left Lung (M/LL) in Gated-SPECT studies with 99mTc-Tetrofosmin. Methodology – A sample of 32 patients, who realized Gated-SPECT studies, by clinical indication, was subdivided into two groups: Group I(GI): patients with clinical information of acute myocardial infarction (AMI), Group II(GII): patients with clinical information of ischemia. For each patient were acquired thoraco-abdominal static views and two Gated- SPECT myocardial studies (one-day protocol stress/rest). Were drawn regions of interest (ROIs) to calculate UI’s M/RL M/LL in static views. In Gated-SPECT studies, was used the software Quantitative Gated SPECT/Quantitative Perfusion SPECT to calculate the LV Ejection Fraction (LVEF). We performed descriptive statistical analysis to sample characterization. Were applied Spearman’s test between LVEF and UI by patient groups. Willcoxon test was used to compare LVEF at stress and rest. Results: In Gated-SPECT studies at stress, correlations between LVEF and UIs were not statistically significant, to GI and GII; at rest, it’s a positive correlation statistically significant between LVEF and UIs, for GI; to GII no correlation was found. In the comparison of stress and rest LVEF values, in both groups, was deemed to exist statistically significant differences, with the LVEF in stress<LVEF at rest, to GI and GII. Conclusion – UI associated with LVEF value will be an indicator of LV dysfunction, nevertheless, it is not viably applicable this deduction for the whole sample, who realized Gated-SPECT (GI and GII).