Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report

Detalhes bibliográficos
Autor(a) principal: Luz, André
Data de Publicação: 2020
Outros Autores: Amaral, Cláudia, Silveira, Inês, Trêpa, Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.16/2595
Resumo: Background: Mediastinal paragangliomas (PGs) are rare and particularly challenging neuroendocrine tumours. Clinical presentation is heterogeneous and tumour resection can be challenging due to bleeding and the risk of catecholamine surges in functional tumours. Case summary: A 36-year-old man with multiple cardiovascular risk factors was admitted with subacute heart failure. Investigations revealed a large non-metastatic functional mediastinal PG irrigated mainly by a left circumflex coronary anomalous feeder branch. The surgical risk was deemed very high due to patient comorbidities, tumour vascularization, and close relation to major thoracic structures. A multidisciplinary team decided to perform embolization of the anomalous coronary branch followed by peptide-receptor radionuclide therapy with 177-LuDOTATE aiming to decrease tumour size and perioperative risk. Follow-up studies showed a reduction in tumour vascularization, size, and hormonal production. Discussion: The innovative strategy of combining embolization of the anomalous feeder branch with radionuclide therapy proved to be a promising approach.
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spelling Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case reportCase reportCoronary embolizationMediastinal paragangliomaNeuroendocrine tumourRadionuclide therapyBackground: Mediastinal paragangliomas (PGs) are rare and particularly challenging neuroendocrine tumours. Clinical presentation is heterogeneous and tumour resection can be challenging due to bleeding and the risk of catecholamine surges in functional tumours. Case summary: A 36-year-old man with multiple cardiovascular risk factors was admitted with subacute heart failure. Investigations revealed a large non-metastatic functional mediastinal PG irrigated mainly by a left circumflex coronary anomalous feeder branch. The surgical risk was deemed very high due to patient comorbidities, tumour vascularization, and close relation to major thoracic structures. A multidisciplinary team decided to perform embolization of the anomalous coronary branch followed by peptide-receptor radionuclide therapy with 177-LuDOTATE aiming to decrease tumour size and perioperative risk. Follow-up studies showed a reduction in tumour vascularization, size, and hormonal production. Discussion: The innovative strategy of combining embolization of the anomalous feeder branch with radionuclide therapy proved to be a promising approach.Oxford University PressRepositório Científico do Centro Hospitalar Universitário de Santo AntónioLuz, AndréAmaral, CláudiaSilveira, InêsTrêpa, Maria2021-11-22T14:19:30Z2020-04-172020-04-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2595engTrêpa M, Silveira I, Amaral C, Luz A. Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report. Eur Heart J Case Rep. 2020;4(3):1-6. doi:10.1093/ehjcr/ytaa0622514-211910.1093/ehjcr/ytaa062info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T11:01:13Zoai:repositorio.chporto.pt:10400.16/2595Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:47.639214Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report
title Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report
spellingShingle Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report
Luz, André
Case report
Coronary embolization
Mediastinal paraganglioma
Neuroendocrine tumour
Radionuclide therapy
title_short Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report
title_full Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report
title_fullStr Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report
title_full_unstemmed Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report
title_sort Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report
author Luz, André
author_facet Luz, André
Amaral, Cláudia
Silveira, Inês
Trêpa, Maria
author_role author
author2 Amaral, Cláudia
Silveira, Inês
Trêpa, Maria
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Centro Hospitalar Universitário de Santo António
dc.contributor.author.fl_str_mv Luz, André
Amaral, Cláudia
Silveira, Inês
Trêpa, Maria
dc.subject.por.fl_str_mv Case report
Coronary embolization
Mediastinal paraganglioma
Neuroendocrine tumour
Radionuclide therapy
topic Case report
Coronary embolization
Mediastinal paraganglioma
Neuroendocrine tumour
Radionuclide therapy
description Background: Mediastinal paragangliomas (PGs) are rare and particularly challenging neuroendocrine tumours. Clinical presentation is heterogeneous and tumour resection can be challenging due to bleeding and the risk of catecholamine surges in functional tumours. Case summary: A 36-year-old man with multiple cardiovascular risk factors was admitted with subacute heart failure. Investigations revealed a large non-metastatic functional mediastinal PG irrigated mainly by a left circumflex coronary anomalous feeder branch. The surgical risk was deemed very high due to patient comorbidities, tumour vascularization, and close relation to major thoracic structures. A multidisciplinary team decided to perform embolization of the anomalous coronary branch followed by peptide-receptor radionuclide therapy with 177-LuDOTATE aiming to decrease tumour size and perioperative risk. Follow-up studies showed a reduction in tumour vascularization, size, and hormonal production. Discussion: The innovative strategy of combining embolization of the anomalous feeder branch with radionuclide therapy proved to be a promising approach.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-17
2020-04-17T00:00:00Z
2021-11-22T14:19:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.16/2595
url http://hdl.handle.net/10400.16/2595
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Trêpa M, Silveira I, Amaral C, Luz A. Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report. Eur Heart J Case Rep. 2020;4(3):1-6. doi:10.1093/ehjcr/ytaa062
2514-2119
10.1093/ehjcr/ytaa062
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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