Low-dose effects of Bisphenol A on human primary and cancer cells
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Livro |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/6653 |
Resumo: | Bisphenol A (BPA), 2,2-bis(4-hydroxyphenyl) propane is an organic compound and one of the greatest volume industrial chemicals produced worldwide. Human exposure to BPA, in the range of the called “low-doses”, is considered a generalized phenomenon particularly through oral intake. Biomonitoring studies reveal the presence of BPA in the majority of the individuals from developed countries. BPA is a well characterized endocrine disruptor which can endorse very distinct cellular responses through several estrogen receptor signalling pathways frequently associated to cell type specificities. Extensive research in human cell lines from sex hormone responsive tissues have demonstrated the potential harmful effects of BPA exposure including carcinogenesis. However, although BPA is absorbed in the gut and enters blood circulation, its effects on cells from digestive or vascular systems are largely unknown. There is an urgent need to address increasing concerns regarding the potential adverse effects of BPA low-dose exposures and to evaluate potential interactions in the context of human health risk assessment. |
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Low-dose effects of Bisphenol A on human primary and cancer cellsBisphenol ADosimetryHuman exposureBisphenol A (BPA), 2,2-bis(4-hydroxyphenyl) propane is an organic compound and one of the greatest volume industrial chemicals produced worldwide. Human exposure to BPA, in the range of the called “low-doses”, is considered a generalized phenomenon particularly through oral intake. Biomonitoring studies reveal the presence of BPA in the majority of the individuals from developed countries. BPA is a well characterized endocrine disruptor which can endorse very distinct cellular responses through several estrogen receptor signalling pathways frequently associated to cell type specificities. Extensive research in human cell lines from sex hormone responsive tissues have demonstrated the potential harmful effects of BPA exposure including carcinogenesis. However, although BPA is absorbed in the gut and enters blood circulation, its effects on cells from digestive or vascular systems are largely unknown. There is an urgent need to address increasing concerns regarding the potential adverse effects of BPA low-dose exposures and to evaluate potential interactions in the context of human health risk assessment.LAP LAMBERT Academic PublishingRCIPLRibeiro-Varandas, Edna2016-12-21T21:46:04Z2016-012016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookapplication/pdfhttp://hdl.handle.net/10400.21/6653engRibeiro-Varandas E. Low-dose effects of Bisphenol A on human primary and cancer cells. LAP LAMBERT Academic Publishing; 2016.9783659827761metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:51:40Zoai:repositorio.ipl.pt:10400.21/6653Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:15:44.094755Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Low-dose effects of Bisphenol A on human primary and cancer cells |
title |
Low-dose effects of Bisphenol A on human primary and cancer cells |
spellingShingle |
Low-dose effects of Bisphenol A on human primary and cancer cells Ribeiro-Varandas, Edna Bisphenol A Dosimetry Human exposure |
title_short |
Low-dose effects of Bisphenol A on human primary and cancer cells |
title_full |
Low-dose effects of Bisphenol A on human primary and cancer cells |
title_fullStr |
Low-dose effects of Bisphenol A on human primary and cancer cells |
title_full_unstemmed |
Low-dose effects of Bisphenol A on human primary and cancer cells |
title_sort |
Low-dose effects of Bisphenol A on human primary and cancer cells |
author |
Ribeiro-Varandas, Edna |
author_facet |
Ribeiro-Varandas, Edna |
author_role |
author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Ribeiro-Varandas, Edna |
dc.subject.por.fl_str_mv |
Bisphenol A Dosimetry Human exposure |
topic |
Bisphenol A Dosimetry Human exposure |
description |
Bisphenol A (BPA), 2,2-bis(4-hydroxyphenyl) propane is an organic compound and one of the greatest volume industrial chemicals produced worldwide. Human exposure to BPA, in the range of the called “low-doses”, is considered a generalized phenomenon particularly through oral intake. Biomonitoring studies reveal the presence of BPA in the majority of the individuals from developed countries. BPA is a well characterized endocrine disruptor which can endorse very distinct cellular responses through several estrogen receptor signalling pathways frequently associated to cell type specificities. Extensive research in human cell lines from sex hormone responsive tissues have demonstrated the potential harmful effects of BPA exposure including carcinogenesis. However, although BPA is absorbed in the gut and enters blood circulation, its effects on cells from digestive or vascular systems are largely unknown. There is an urgent need to address increasing concerns regarding the potential adverse effects of BPA low-dose exposures and to evaluate potential interactions in the context of human health risk assessment. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-21T21:46:04Z 2016-01 2016-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/book |
format |
book |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/6653 |
url |
http://hdl.handle.net/10400.21/6653 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ribeiro-Varandas E. Low-dose effects of Bisphenol A on human primary and cancer cells. LAP LAMBERT Academic Publishing; 2016. 9783659827761 |
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metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
LAP LAMBERT Academic Publishing |
publisher.none.fl_str_mv |
LAP LAMBERT Academic Publishing |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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