The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: A case-control study in the Portuguese population

Detalhes bibliográficos
Autor(a) principal: Silva, Susana N.
Data de Publicação: 2009
Outros Autores: Azevedo, Ana Paula, Teixeira, Valdemar, Pina, Julieta Esperança, Rueff, José, Gaspar, Jorge Francisco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/24224
Resumo: We wish to thank Luisa Manso Oliveira, Lylliane Luz, Silvia Morgado Amaro and Maria Catarina Soveral for technical support. Center for Research in Human Molecular Genetics (CIGMH), Projects POCTI/QUI/57110/2004 from Fundacao da Ciencia e Tecnologia (FCT) and Fundacao Calouste Gulbenkian (Grant 69405) support our current research. The PhD grant SFRH/BD/17828/2004 from FCT is also acknowledged.
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spelling The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: A case-control study in the Portuguese populationbreast cancerGENETIC POLYMORPHISMSgenetic susceptibilityTRANSFERASE A2GSTP1EXPRESSIONGENOTYPERISKGSTM1FUNCTIONAL POLYMORPHISMMETABOLIZING GENESGSTA2 polymorphismsGSTT1Breast cancerGenetic susceptibilityGSTA2 polymorphismsSDG 3 - Good Health and Well-beingWe wish to thank Luisa Manso Oliveira, Lylliane Luz, Silvia Morgado Amaro and Maria Catarina Soveral for technical support. Center for Research in Human Molecular Genetics (CIGMH), Projects POCTI/QUI/57110/2004 from Fundacao da Ciencia e Tecnologia (FCT) and Fundacao Calouste Gulbenkian (Grant 69405) support our current research. The PhD grant SFRH/BD/17828/2004 from FCT is also acknowledged.Glutathione-S-transferases (GSTs) are a superfamily of phase II metabolizing enzymes that catalyse the detoxification of a large range of endogenous and exogenous toxic compounds, playing an important role in protecting cells against damage, through glutathione conjugation with electrophilic substances. Polymorphic variation in these enzymes that affect its activity seems to be related to individual susceptibility to various human diseases, including cancer. Of the GST super-family, the alpha class GSTs have commonly been described as one of the most versatile class, since it is responsible for detoxification of compounds such as bilirubin, bile acids and penicillin, thyroid and steroid hormones, allowing its solubilization and storage in the liver. Among the alpha class, GSTA1 and GSTA2 isoforms are the most widely expressed in human tissues. Additionally, these enzymes can catalyse conjugation of the nitrogen mustard group of alkylating anticancer drugs, some heterocyclic amines and alpha,beta-unsaturated aldehydes. Since some risk factors for increased breast cancer risk could be related to high production of reactive oxygen species during the metabolism of estrogens by catechol estrogens, or to the exposure to genotoxic compounds, and some of these toxic compounds are usually metabolized by GSTA2, we carried out a hospital based case-control study in a Caucasian Portuguese population (291 breast cancer patients without familiar history of breast cancer and 547 controls matched for age, sex and ethnicity) in order to evaluate the potential modifying role of three non-synonymous polymorphisms in the GSTA2 gene (P110S Ex 5+56C>T;, rs2234951; S112T Ex5+63G>C, rs2180314 and E210A Ex7+83A>C, rs6577) on the individual susceptibility to breast cancer. Our data show that the Studied polymorphisms are in strong linkage disequilibrium, but no association was observed between individual GSTA2 polymorphisms and haplotypes and individual susceptibility to breast cancer.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSilva, Susana N.Azevedo, Ana PaulaTeixeira, ValdemarPina, Julieta EsperançaRueff, JoséGaspar, Jorge Francisco2017-10-16T22:01:07Z2009-092009-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://hdl.handle.net/10362/24224eng1021-335XPURE: 293558https://doi.org/10.3892/or_00000477info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:12:33Zoai:run.unl.pt:10362/24224Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:28:01.007480Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: A case-control study in the Portuguese population
title The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: A case-control study in the Portuguese population
spellingShingle The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: A case-control study in the Portuguese population
Silva, Susana N.
breast cancerGENETIC POLYMORPHISMS
genetic susceptibility
TRANSFERASE A2
GSTP1
EXPRESSION
GENOTYPE
RISK
GSTM1
FUNCTIONAL POLYMORPHISM
METABOLIZING GENES
GSTA2 polymorphisms
GSTT1
Breast cancer
Genetic susceptibility
GSTA2 polymorphisms
SDG 3 - Good Health and Well-being
title_short The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: A case-control study in the Portuguese population
title_full The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: A case-control study in the Portuguese population
title_fullStr The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: A case-control study in the Portuguese population
title_full_unstemmed The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: A case-control study in the Portuguese population
title_sort The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: A case-control study in the Portuguese population
author Silva, Susana N.
author_facet Silva, Susana N.
Azevedo, Ana Paula
Teixeira, Valdemar
Pina, Julieta Esperança
Rueff, José
Gaspar, Jorge Francisco
author_role author
author2 Azevedo, Ana Paula
Teixeira, Valdemar
Pina, Julieta Esperança
Rueff, José
Gaspar, Jorge Francisco
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Silva, Susana N.
Azevedo, Ana Paula
Teixeira, Valdemar
Pina, Julieta Esperança
Rueff, José
Gaspar, Jorge Francisco
dc.subject.por.fl_str_mv breast cancerGENETIC POLYMORPHISMS
genetic susceptibility
TRANSFERASE A2
GSTP1
EXPRESSION
GENOTYPE
RISK
GSTM1
FUNCTIONAL POLYMORPHISM
METABOLIZING GENES
GSTA2 polymorphisms
GSTT1
Breast cancer
Genetic susceptibility
GSTA2 polymorphisms
SDG 3 - Good Health and Well-being
topic breast cancerGENETIC POLYMORPHISMS
genetic susceptibility
TRANSFERASE A2
GSTP1
EXPRESSION
GENOTYPE
RISK
GSTM1
FUNCTIONAL POLYMORPHISM
METABOLIZING GENES
GSTA2 polymorphisms
GSTT1
Breast cancer
Genetic susceptibility
GSTA2 polymorphisms
SDG 3 - Good Health and Well-being
description We wish to thank Luisa Manso Oliveira, Lylliane Luz, Silvia Morgado Amaro and Maria Catarina Soveral for technical support. Center for Research in Human Molecular Genetics (CIGMH), Projects POCTI/QUI/57110/2004 from Fundacao da Ciencia e Tecnologia (FCT) and Fundacao Calouste Gulbenkian (Grant 69405) support our current research. The PhD grant SFRH/BD/17828/2004 from FCT is also acknowledged.
publishDate 2009
dc.date.none.fl_str_mv 2009-09
2009-09-01T00:00:00Z
2017-10-16T22:01:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/24224
url http://hdl.handle.net/10362/24224
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1021-335X
PURE: 293558
https://doi.org/10.3892/or_00000477
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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